Catalog Number: 5128
Biological Activity
Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Ser-1 = N-terminal Ac, X = N5-(2-Chloro-1-iminoethyl)]-Orn)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation.
    Obianyo et al.
    Chembiochem, 2010;11:1219
  2. Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6).
    Obianyo and Thompson
    J.Biol.Chem., 2012;287:6062
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