C3

Catalog # Availability Size / Price Qty
5957/50
5957/10
Cat.No. 5957 - C3 | C23H34N4O | CAS No. 1268709-57-4
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Description: Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor

Chemical Name: N-Cyclopentyl-1-[5,6-dimethyl-1-(1-methylethyl)-1H-benzimidazol-2-yl]-4-piperidinecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

Selective microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 90 and 900 nM for rat and human mPGES-1, respectively). Displays selectivity for mPGES-1 over COX-1, COX-2, PGIS, hPGDS and iPGDS (% inhibition values are 15, 18, 0, 0 and 60 % inhibition at 50 μM, respectively). Reduces PGE2 production in vitro and in a localized inflammation animal model. Elevates CD80 expression by tumor associated phagocytes in vitro. Also decreases vascular contractility, in ex vivo human vessels.

Technical Data

M.Wt:
382.54
Formula:
C23H34N4O
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1268709-57-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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