C3bot (154-182)

Biological Activity

Transferase-deficient neurotrophic fragment of clostridial C3 protein. Promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations. Also promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. Reduces levels of active neuronal RhoA by a non-enzymatic mechanism. Enhances functional recovery and regeneration in a mouse model of spinal cord injury.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation.
   Holtje et al.
   FASEB J., 2009;23:1115
2. C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts.
   Boato et al.
   J.Cell Science, 2010;123:1652
3. Therapeutic effects of Clostridium botulinum C3 exoenzyme.
   Just et al.
   Naunyn-Schmied.Arch.Pharmacol., 2011;383:247

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