Biological ActivityC3bot (154-182) is a transferase-deficient neurotrophic fragment of clostridial C3 protein. Promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations. Also promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. Reduces levels of active neuronal RhoA by a non-enzymatic mechanism. Enhances functional recovery and regeneration in a mouse model of spinal cord injury.
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A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation.
Holtje et al.
FASEB J., 2009;23:1115
C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts.
Boato et al.
J.Cell Science, 2010;123:1652
Therapeutic effects of Clostridium botulinum C3 exoenzyme.
Just et al.
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