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0448 has been discontinued.
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Calpeptin | CAS No. 117591-20-5 | Calcium-Sensitive Protease Modulator Inhibitors
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Description: Calpain and cathepsin L inhibitor

Chemical Name: N-Benzyloxycarbonyl-L-leucylnorleucinal

Product Details
Citations (10)

Biological Activity

Calpeptin is a potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases. Also inhibits SARS-CoV-2 Mpro in vitro (IC50 = 10.7 μM) and inhibits viral replication.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Calpeptin

The citations listed below are publications that use Tocris products. Selected citations for Calpeptin include:

10 Citations: Showing 1 - 10

  1. Calpeptin Reduces Neurobehavioral Deficits and Neuronal Apoptosis Following Subarachnoid Hemorrhage in Rats.
    Authors: Zhou and Cai
    J Stroke Cerebrovasc Dis  2019;28:125
  2. Involvement of calpains in adult neurogenesis: implications for stroke.
    Authors: Machado Et al.
    J Biol Chem  2015;9:22
  3. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
    Authors: Wang Et al.
    J Pharmacol Exp Ther  2015;290:168
  4. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.
    Authors: Rivera-Pagán Et al.
    PLoS One  2015;10:e0125195
  5. Platelet surface-associated activation and secretion-mediated inhibition of coagulation factor XII.
    Authors: Zakharova Et al.
    PLoS One  2015;10:e0116665
  6. Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair.
    Authors: Redpath Et al.
    Mol Biol Cell  2014;25:3037
  7. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms.
    Authors: Chen Et al.
    Pflugers Arch  2013;347:765
  8. Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
    Authors: Santos Et al.
    PLoS One  2012;7:e33468
  9. Mitochondrial control of platelet apoptosis: effect of cyclosporin A, an inhibitor of the mitochondrial permeability transition pore.
    Authors: Leytin Et al.
    Lab Invest  2009;89:374
  10. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.
    Authors: Amadoro Et al.
    Proc Natl Acad Sci U S A  2006;103:2892


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