Potent, cell-permeable inhibitor of the Ca2+
-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.
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Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho.
Schoenwaelder and Burridge
Synthesis of a new cell penetrating calpain inhibitor (calpeptin).
Tsujinaka et al.
Cell-penetrating inhibitors of calpain.
Inhibitory effect of di-and tripeptidyl aldehydes on calpains and cathepsins.
Sasaki et al.
J.Enzyme Inhib., 1990;3:195
The citations listed below are publications that use Tocris products. Selected citations for Calpeptin include:
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