Calpeptin

  ( 8 citations )    
Product Datasheet
Catalog Number:0448
Chemical Name:N-Benzyloxycarbonyl-L-leucylnorleucinal
Product Details
Citations (8)
Reviews
Biological Activity
Potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.
Technical Data
  • M.Wt:
    362.47
  • Formula:
    C20H30N2O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Desiccate at +4°C
  • CAS No:
    117591-20-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Calpeptin include:

8 Citations: Showing 1 - 8
Filter your results:

  1. Involvement of calpains in adult neurogenesis: implications for stroke.
    Authors: Machado Et al.
    J Biol Chem  2015;9:22
  2. MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
    Authors: Wang Et al.
    J Pharmacol Exp Ther  2015;290:168
  3. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.
    Authors: Rivera-Pagán Et al.
    PLoS One  2015;10:e0125195
  4. Platelet surface-associated activation and secretion-mediated inhibition of coagulation factor XII.
    Authors: Zakharova Et al.
    PLoS One  2015;10:e0116665
  5. Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair.
    Authors: Redpath Et al.
    Mol Biol Cell  2014;25:3037
  6. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms.
    Authors: Chen Et al.
    Pflugers Arch  2013;347:765
  7. Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
    Authors: Santos Et al.
    PLoS One  2012;7:e33468
  8. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.
    Authors: Amadoro Et al.
    Proc Natl Acad Sci U S A  2006;103:2892

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used Calpeptin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee