Catalog Number: 0448
Chemical Name: N-Benzyloxycarbonyl-L-leucylnorleucinal
Biological Activity
Potent, cell-permeable inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho.
    Schoenwaelder and Burridge
    J.Biol.Chem., 1999;274:14359
  2. Synthesis of a new cell penetrating calpain inhibitor (calpeptin).
    Tsujinaka et al.
    Biochem.Biophys.Res.Commun., 1988;153:1201
  3. Cell-penetrating inhibitors of calpain.
    TiBS, 1991;16:150
  4. Inhibitory effect of di-and tripeptidyl aldehydes on calpains and cathepsins.
    Sasaki et al.
    J.Enzyme Inhib., 1990;3:195
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