Catalog Number: 4455
Chemical Name: 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline
Biological Activity
Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM). Also displays reversible, competitive inhibition of leukotriene A4 (LTA4) hydrolase.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of early captopril treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY).
    Zhang et al.
    Clin.Exp.Hypertens., 1996;18:201
  2. Inhibition of leukotriene A4 hydrolase/aminopeptidase by captopril.
    Orning et al.
    J.Biol.Chem., 1991;266:16507
  3. LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein.
    Fujita and Yoshikawa
    Immunopharmacology., 1999;44:123
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