Chemical Name: 1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-L-proline
Biological ActivityCaptopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM). Also displays reversible, competitive inhibition of leukotriene A4 (LTA4) hydrolase. Identified as targeting human host proteins that interact with SARS-CoV-2.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein.
Fujita and Yoshikawa
Effects of early capt. treatment and its removal on plasma angiotensin converting enzyme (ACE) activity and arginine vasopressin in hypertensive rats (SHR) and normotensive rats (WKY).
Zhang et al.
Inhibition of leukotriene A4 hydrolase/aminopeptidase by capt.
Orning et al.
A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing.
Gordon et al.
Citation for Captopril
The citations listed below are publications that use Tocris products. Selected citations for Captopril include:
1 Citation: Showing 1 - 1
Opioid receptor function is regulated by post-endocytic peptide processing.
Authors: Gupta Et al.
J Biol Chem 2014;289:19613
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