Carboxy-PTIO, potassium salt
Chemical Name: 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt
Biological ActivityA stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonistic action of imidazolineoxy N-oxides against endothelium-derived relaxing factor/NO through a radical reaction.
Akaike et al.
Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF.
Rand and Li
Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies.
Tsunoda et al.
Citations for Carboxy-PTIO, potassium salt
The citations listed below are publications that use Tocris products. Selected citations for Carboxy-PTIO, potassium salt include:
11 Citations: Showing 1 - 10
Selective activation of microglia facilitates synaptic strength.
Authors: Clark Et al.
Cardiovasc Res 2015;35:4552
Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity.
Authors: Echeverría Et al.
PLoS One 2014;9:e94146
An anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test.
Authors: Carlile Et al.
Life Sci 2012;90:267
Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons.
Authors: Jin Et al.
Korean J Physiol Pharmacol 2012;16:211
The role of vascular myoglobin in nitrite-mediated blood vessel relaxation.
Authors: Ormerod Et al.
Br J Pharmacol 2011;89:560
The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice.
Authors: Quock Et al.
Brain Res 2011;1368:102
Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning.
Authors: Ota Et al.
PLoS One 2010;5:e11236
The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses.
Authors: Ping and Schafe
Neural Plast 2010;2010:540940
Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning.
Authors: Ota Et al.
Learn Mem 2010;17:221
Modulation of inhibitory activity by nitric oxide in the thalamus.
J Neurophysiol 2007;97:3386
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