Caspase-1/ICE Inhibitor Z-WEHD-FMK
Caspase-1/ICE Inhibitor Z-WEHD-FMK Summary
Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.
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Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).
Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.
Citations for Caspase-1/ICE Inhibitor Z-WEHD-FMK
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 10
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CLEC5A is critical in Pseudomonas aeruginosa-induced acute lung injury
Authors: PS Sung, YC Peng, SP Yang, CH Chiu, SL Hsieh
JCI Insight, 2022;0(0):. 2022
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
Authors: W Deng, Y Bai, F Deng, Y Pan, S Mei, Z Zheng, R Min, Z Wu, W Li, R Miao, Z Zhang, TS Kupper, J Lieberman, X Liu
Nature, 2022;0(0):. 2022
Scorpion Venom Antimicrobial Peptides Induce Caspase-1 Dependant Pyroptotic Cell Death
Authors: RA Elrayess, ME Mohallal, YM Mobarak, HM Ebaid, S Haywood-Sm, K Miller, PN Strong, MA Abdel-Rahm
Frontiers in Pharmacology, 2021;12(0):788874. 2021
Human fetal membrane IL-1beta production in response to bacterial components is mediated by uric-acid induced NLRP3 inflammasome activation
Authors: AS Miller, TN Hidalgo, VM Abrahams
Journal of reproductive immunology, 2021;149(0):103457. 2021
Caspase-1 Inhibition Impacts the Formation of Chondrogenic Nodules, and the Expression of Markers Related to Osteogenic Differentiation and Lipid Metabolism
Authors: A Ramesova, B Vesela, E Svandova, H Lesot, E Matalova
International Journal of Molecular Sciences, 2021;22(17):. 2021
The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity
Authors: C Xu, S Sun, T Johnson, R Qi, S Zhang, J Zhang, K Yang
Cell Reports, 2021;35(11):109235. 2021
NLRP3 inflammasome function and pyroptotic cell death in human placental Hofbauer cells
Authors: VM Abrahams, Z Tang, G Mor, S Guller
J Reprod Immunol, 2020;142(0):103214. 2020
NLRP3 Inflammasome is Activated in Rat Pancreatic Islets by Transplantation and Hypoxia
Authors: V Lavallard, D Cottet-Dum, CH Wassmer, C Rouget, G Parnaud, E Brioudes, F Lebreton, K Bellofatto, E Berishvili, T Berney, D Bosco
Sci Rep, 2020;10(1):7011. 2020
A Novel Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo
Authors: S Talley, O Kalinina, M Winek, W Paik, AR Cannon, F Alonzo, MA Choudhry, KL Knight, EM Campbell
J. Immunol., 2019;0(0):. 2019
HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis
Authors: B Corleis, AN Bucsan, M Deruaz, VD Vrbanac, AC Lisanti-Pa, SJ Gates, AH Linder, JM Paer, GS Olson, BA Bowman, AE Schiff, BD Medoff, AM Tager, AD Luster, SA Khader, D Kaushal, DS Kwon
Cell Rep, 2019;26(6):1409-1418.e5. 2019
Effects of metal ions on caspase-1 activation and interleukin-1? release in murine bone marrow-derived macrophages
Authors: MA Ferko, I Catelas
PLoS ONE, 2018;13(8):e0199936. 2018
The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages
Authors: Z Czimmerer, B Daniel, A Horvath, D Rückerl, G Nagy, M Kiss, M Peloquin, MM Budai, I Cuaranta-M, Z Simandi, L Steiner, B Nagy, S Poliska, C Banko, Z Bacso, IG Schulman, S Sauer, JF Deleuze, JE Allen, S Benko, L Nagy
Immunity, 2018;48(1):75-90.e6. 2018
Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia
Authors: N Gonzalez-J, KM Bradley, AN Riegler, LF Reyes, T Brissac, SS Park, MI Restrepo, CJ Orihuela
Sci Rep, 2018;8(1):5846. 2018
Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1?/TNFAIP3 Axis
Authors: Y Kang, H Zhang, Y Zhao, Y Wang, W Wang, Y He, W Zhang, W Zhang, X Zhu, Y Zhou, L Zhang, Z Ju, L Shi
Cell Rep, 2018;22(13):3493-3506. 2018
Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction
Authors: KM Boini, T Hussain, PL Li, SS Koka
Cell. Physiol. Biochem., 2017;44(1):152-162. 2017
Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation
Authors: SN Cross, JA Potter, P Aldo, JY Kwon, M Pitruzzell, M Tong, S Guller, CV Rothlin, G Mor, VM Abrahams
J. Immunol., 2017;0(0):. 2017
Production and regulation of interleukin-1 family cytokines at the materno-fetal interface
Authors: LM Scott, AH Bryant, A Rees, B Down, RH Jones, CA Thornton
Cytokine, 2017;0(0):. 2017
Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor
Authors: R Soto, C Petersen, CL Novis, JL Kubinak, R Bell, WZ Stephens, TE Lane, RS Fujinami, A Bosque, RM O'Connell, JL Round
Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017
Stress fibers, autophagy and necrosis by persistent exposure to PM2.5 from biomass combustion
Authors: R Dornhof, C Maschowski, A Osipova, R Gieré, M Seidl, I Merfort, M Humar
PLoS ONE, 2017;12(7):e0180291. 2017
Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells
Sci Rep, 2016;6(0):37433. 2016
The flagellar regulator TviA reduces pyroptosis by Salmonella enterica serovar Typhi.
Authors: Winter S, Winter M, Atluri V, Poon V, Romao E, Tsolis R, Baumler A
Infect Immun, 2015;83(4):1546-55. 2015
Spleen Tyrosine Kinase (Syk) Mediates IL-1beta Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.
Authors: Callaway J, Smith S, McKinnon K, de Silva A, Crowe J, Ting J
J Biol Chem, 2015;290(28):17306-20. 2015
Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
PLoS ONE, 2015;10(8):e0136708. 2015
Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
Authors: Gonzalez-Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, Dube P, Bergman M, Orihuela C
PLoS Pathog, 2015;11(12):e1005337. 2015
Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin.
Authors: Xia M, Boini K, Abais J, Xu M, Zhang Y, Li P
Am J Pathol, 2014;184(5):1617-28. 2014
Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity.
Authors: Teigler J, Kagan J, Barouch D
J Virol, 2014;88(18):10354-63. 2014
Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.
Authors: Mukherjee P, Woods T, Moore R, Peterson K
Immunity, 2013;38(4):705-16. 2013
Leptin enhances the secretion of interleukin (IL)-18, but not IL-1beta, from human monocytes via activation of caspase-1.
Authors: Jitprasertwong P, Jaedicke K, Nile C, Preshaw P, Taylor J
Cytokine, 2013;65(2):222-30. 2013
Bacillus anthracis capsule activates caspase-1 and induces interleukin-1beta release from differentiated THP-1 and human monocyte-derived dendritic cells.
Authors: Cho MH, Ahn HJ, Ha HJ, Park J, Chun JH, Kim BS, Oh HB, Rhie GE
Infect. Immun., 2010;78(1):387-92. 2010
Active caspase-1-mediated secretion of retinoic acid inducible gene-I.
Authors: Kim, Min-Jung, Yoo, Joo-Yeon
J Immunol, 2008;181(10):7324-31. 2008
Induction of immature dendritic cell apoptosis by foot and mouth disease virus is an integrin receptor mediated event before viral infection.
Authors: Jin H, Xiao C, Zhao G, Du X, Yu Y, Kang Y, Wang B
J. Cell. Biochem., 2007;102(4):980-91. 2007
RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
Blood, 2004;103(11):4180-7. 2004
Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?
Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.
Are R&D Systems Caspase Inhibitors irreversible?
Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.
R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.
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