Caspase-3 Inhibitor Z-DEVD-FMK

Catalog # Availability Size / Price Qty
Product Details
Citations (75)

Caspase-3 Inhibitor Z-DEVD-FMK Summary

Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.


Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Product Datasheets

You must select a language.


Background: Caspase-3

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

Entrez Gene IDs
836 (Human); 12367 (Mouse)
Alternate Names
Apopain; apoptosis-related cysteine protease; CASP3; CASP-3; caspase 3, apoptosis-related cysteine peptidase; Caspase3; Caspase-3; CPP32; CPP-32; CPP32B; CPP32SREBP cleavage activity 1; Cysteine protease CPP32; EC 3.4.22; EC; LICE-1; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; YAMA

Citations for Caspase-3 Inhibitor Z-DEVD-FMK

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

75 Citations: Showing 1 - 10
Filter your results:

Filter by:

  1. Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery
    Authors: K Hiratsuka, T Miyoshi, KT Kroll, NR Gupta, MT Valerius, T Ferrante, M Yamashita, JA Lewis, R Morizane
    Science Advances, 2022;8(38):eabq0866.  2022
  2. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
    Authors: D Beillevair, F Migneault, J Turgeon, D Gingras, AK Rimbaud, G Marcoux, C Spino, N Thibodeau, E Bonneil, P Thibault, É Boilard, M Dieudé, MJ Hébert
    Cell Death & Disease, 2022;13(2):145.  2022
  3. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
    Authors: W Deng, Y Bai, F Deng, Y Pan, S Mei, Z Zheng, R Min, Z Wu, W Li, R Miao, Z Zhang, TS Kupper, J Lieberman, X Liu
    Nature, 2022;0(0):.  2022
  4. 2-Chlorodeoxyadenosine (Cladribine) preferentially inhibits the biological activity of microglial cells
    Authors: F Aybar, M Julia Pere, M Silvina Ma, M Eugenia Sa, M Marrodan, J María Pasq, J Correale
    International immunopharmacology, 2022;105(0):108571.  2022
  5. Selective Anti-Cancer Effects of Plasma-Activated Medium and Its High Efficacy with Cisplatin on Hepatocellular Carcinoma with Cancer Stem Cell Characteristics
    Authors: Y Li, T Tang, HJ Lee, K Song
    International Journal of Molecular Sciences, 2021;22(8):.  2021
  6. LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy
    Authors: P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara
    Embo Molecular Medicine, 2021;0(0):e14511.  2021
  7. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
    Authors: S Rastogi, S Ellinwood, J Augenstrei, KD Mayer-Barb, V Briken
    PloS Pathogens, 2021;17(7):e1009712.  2021
  8. N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways
    Authors: K Woo, DH Kim, MH Oh, HS Park, CH Choi
    International Journal of Molecular Sciences, 2021;22(14):.  2021
  9. The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer
    Authors: AS Qadir, AM Stults, AE Murmann, ME Peter
    Sci Rep, 2020;10(1):1310.  2020
  10. PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis
    Authors: J Hou, R Zhao, W Xia, CW Chang, Y You, JM Hsu, L Nie, Y Chen, YC Wang, C Liu, WJ Wang, Y Wu, B Ke, JL Hsu, K Huang, Z Ye, Y Yang, X Xia, Y Li, CW Li, B Shao, JA Tainer, MC Hung
    Nat. Cell Biol., 2020;0(0):.  2020
  11. The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
    Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
    EBioMedicine, 2020;60(0):102984.  2020
  12. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
    Authors: A Kratochvíl, B Veselá, V Ledvina, E Švandová, K Klepárník, K Dadáková, P Beneš, E Matalová
    Sci Rep, 2020;10(1):7489.  2020
  13. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease
    Authors: G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo
    Cell Rep, 2020;31(13):107839.  2020
  14. Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling
    Authors: H Shen, H Zhu, D Panja, Q Gu, Z Li
    Nat Commun, 2020;11(1):2979.  2020
  15. Discovery of the Biginelli hybrids as novel caspase-9 activators in apoptotic machines: Lipophilicity, molecular docking study, influence on angiogenesis gene and miR-21 expression levels
    Authors: N Jankovi?, J Trifunovi?, M Vraneš, A Tot, J Petronijev, N Joksimovi?, T Stanojkovi, M ?or?i? Crn, N Petrovi?, I Boljevi?, IZ Mati?, GA Bogdanovi?, M Mikov, Z Bugar?i?
    Bioorg. Chem., 2019;86(0):569-582.  2019
  16. PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway
    Authors: JH Baek, HS Yun, GT Kwon, J Lee, JY Kim, Y Jo, JM Cho, CW Lee, JY Song, J Ahn, JS Kim, EH Kim, SG Hwang
    Cell Death Dis, 2019;10(3):156.  2019
  17. Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells
    Authors: E Alharris, NP Singh, PS Nagarkatti, M Nagarkatti
    Oncotarget, 2019;10(1):45-59.  2019
  18. HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis
    Authors: B Corleis, AN Bucsan, M Deruaz, VD Vrbanac, AC Lisanti-Pa, SJ Gates, AH Linder, JM Paer, GS Olson, BA Bowman, AE Schiff, BD Medoff, AM Tager, AD Luster, SA Khader, D Kaushal, DS Kwon
    Cell Rep, 2019;26(6):1409-1418.e5.  2019
  19. Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells
    Authors: J Yu, S Li, J Qi, Z Chen, Y Wu, J Guo, K Wang, X Sun, J Zheng
    Cell Death Dis, 2019;10(3):193.  2019
  20. Efficient biofunctionalization of MoS2 nanosheets with peptides as intracellular fluorescent biosensor for sensitive detection of caspase-3 activity
    Authors: X Li, Y Li, Q Qiu, Q Wen, Q Zhang, W Yang, L Yuwen, L Weng, L Wang
    J Colloid Interface Sci, 2019;543(0):96-105.  2019
  21. Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture
    Authors: AM Giebel, S Hu, K Rajaram, R Finethy, E Toh, JA Brothwell, SG Morrison, RJ Suchland, BD Stein, J Coers, RP Morrison, DE Nelson
    MBio, 2019;10(2):.  2019
  22. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells
    Authors: JK Trittmann, H Almazroue, Y Jin, LD Nelin
    Physiol Rep, 2019;7(12):e14150.  2019
  23. C33-A cells transfected with E6*I or E6*II the short forms of HPV-16 E6, displayed opposite effects on cisplatin-induced apoptosis
    Authors: CE Vaisman, O Del Moral-, S Moreno-Cam, E Aréchaga-O, R Bonilla-Mo, I Garcia-Agu, L Cedillo-Ba, J Berumen, P Nava, N Villegas-S
    Virus Res., 2018;247(0):94-101.  2018
  24. Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3
    Authors: S Panneer Se, BM Roth, R Nganga, J Kim, MA Cooley, KL Helke, CD Smith, B Ogretmen
    J. Biol. Chem., 2018;0(0):.  2018
  25. Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
    Authors: G Bieri, KM Lucin, CE O'Brien, H Zhang, SA Villeda, T Wyss-Coray
    Mol Neurodegener, 2018;13(1):68.  2018
  26. Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity
    Authors: A Kaminski, KH Gupta, JW Goldufsky, HW Lee, V Gupta, SH Shafikhani
    Sci Rep, 2018;8(1):14047.  2018
  27. Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-?B and mitogen-activated protein kinase pathways
    Authors: HE Tzeng, CH Tsai, TY Ho, CT Hsieh, SC Chou, YJ Lee, GJ Tsay, PH Huang, YY Wu
    BMC Complement Altern Med, 2018;18(1):132.  2018
  28. Differentiated Macrophages Acquire a Pro-Inflammatory and Cell Death-Resistant Phenotype Due to Increasing XIAP and P38-mediated inhibition of RipK1
    Authors: D Rijal, A Ariana, A Wight, K Kim, NA Alturki, Z Aamir, E Ametepe, RG Korneluk, C Tiedje, MB Menon, M Gaestel, S McComb, S Sad
    J. Biol. Chem., 2018;0(0):.  2018
  29. Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
    Authors: Bo Ra You, Bo Ram Han, Woo Hyun Park
    Oncotarget, 2017;0(0):1949-2553.  2017
  30. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
    Authors: HJ Kim, KE Hwang, DS Park, SH Oh, HY Jun, KH Yoon, ET Jeong, HR Kim, YS Kim
    J Transl Med, 2017;15(1):123.  2017
  31. Immature human DCs efficiently translocate endocytosed antigens into the cytosol for proteasomal processing
    Authors: RB Baleeiro, P Walden
    Mol. Immunol., 2017;88(0):148-154.  2017
  32. Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor
    Authors: R Soto, C Petersen, CL Novis, JL Kubinak, R Bell, WZ Stephens, TE Lane, RS Fujinami, A Bosque, RM O'Connell, JL Round
    Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.  2017
  33. Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect
    Authors: T Sithara, KB Arun, HP Syama, TR Reshmitha, P Nisha
    Front Pharmacol, 2017;8(0):640.  2017
  34. Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
    Oncotarget, 2016;7(26):40531-40545.  2016
  35. Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells.
    Authors: Cheung S, Chuang P, Huang H, Hwang-Verslues W, Cho C, Yang W, Shen C, Hsiao M, Hsu T, Chang C, Wong C
    Proc Natl Acad Sci U S A, 2016;113(4):960-5.  2016
  36. IL-1? is an innate immune sensor of microbial proteolysis
    Authors: CN LaRock, J Todd, DL LaRock, J Olson, AJ O'Donoghue, AA Robertson, MA Cooper, HM Hoffman, V Nizet
    Sci Immunol, 2016;1(2):.  2016
  37. Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells
    Sci Rep, 2016;6(0):37433.  2016
  38. Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
    Authors: O Arizmendi, WD Picking, WL Picking
    Infect Immun, 2016;0(0):.  2016
  39. Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
    Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
    PLoS ONE, 2015;10(8):e0136708.  2015
  40. Mesenchymal Wnt/beta-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10.
    Authors: Yang Z, Balic A, Michon F, Juuri E, Thesleff I
    Stem Cells, 2015;33(5):1670-81.  2015
  41. Tumor Necrosis Factor-alpha (TNFalpha)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
    Authors: Hernandez-Corbacho M, Canals D, Adada M, Liu M, Senkal C, Yi J, Mao C, Luberto C, Hannun Y, Obeid L
    J Biol Chem, 2015;290(42):25356-73.  2015
  42. Ethanol extracts of Cinnamomum kanehirai Hayata leaves induce apoptosis in human hepatoma cell through caspase-3 cascade.
    Authors: Liu, Yu-Kuo, Chen, Kuan-Hsi, Leu, Yann-Lii, Way, Tzong-De, Wang, Ling-Wei, Chen, Yu-Jen, Liu, Yu-Ming
    Onco Targets Ther, 2014;8(0):99-109.  2014
  43. How liposomal Cisplatin overcomes chemoresistance in ovarian tumour cells.
    Anticancer Res, 2014;34(1):525-30.  2014
  44. Anti-apoptotic effect of caspase inhibitors on H(2)O(2)-treated HeLa cells through early suppression of its oxidative stress.
    Authors: Park W
    Oncol Rep, 2014;31(5):2413-21.  2014
  45. Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development.
    Authors: Lin J, Lin S, Chen W, Yen Y, Lai C, Tao M, Lin Y, Miaw S, Wu-Hsieh B
    J Immunol, 2014;193(3):1258-67.  2014
  46. Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma.
    Authors: Wang, Jian-Gan, Zheng, Xing-Xin, Zeng, Guang-Ya, Zhou, Ying-Jun, Yuan, Hong
    Oncol Rep, 2014;31(1):488-96.  2014
  47. Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
    Authors: You B, Park W
    Int J Oncol, 2014;44(5):1745-55.  2014
  48. PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
    Authors: You B, Shin H, Park W
    Int J Oncol, 2014;44(1):301-8.  2014
  49. 5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-delta
    Authors: Mhaidat N, Bouklihacene M, Thorne R
    Oncol Lett, 2014;8(2):699-704.  2014
  50. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis.
    Authors: Han B, You B, Park W
    Oncol Rep, 2013;30(6):2999-3005.  2013
  51. HOCl-dependent singlet oxygen and hydroxyl radical generation modulate and induce apoptosis of malignant cells.
    Authors: Bauer G
    Anticancer Res, 2013;33(9):3589-602.  2013
  52. Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
    Authors: D'Agnillo, Felice, Williams, Matthew, Moayeri, Mahtab, Warfel, Jason M
    PLoS ONE, 2013;8(4):e62576.  2013
  53. The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells.
    Authors: Liao Y, Lu C, Lai K, Yang J, Kuo S, Wen Y, Fushiya S, Wu T
    Mol Med Rep, 2013;7(5):1539-44.  2013
  54. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.
    Authors: Jin, Yunyun, Xu, Jinjin, Yin, Meng-Xin, Lu, Yi, Hu, Lianxin, Li, Peixue, Zhang, Peng, Yuan, Zengqian, Ho, Margaret, Ji, Hongbin, Zhao, Yun, Zhang, Lei
    Elife, 2013;2(0):e00999.  2013
  55. Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani.
    Authors: Chakravarthi B, Sujay R, Kuriakose G, Karande A, Jayabaskaran C
    Cancer Cell Int, 2013;13(1):105.  2013
  56. Inhibition of nuclear factor-kappa B activation decreases survival of Mycobacterium tuberculosis in human macrophages.
    Authors: Bai X, Feldman N, Chmura K, Ovrutsky A, Su W, Griffin L, Pyeon D, McGibney M, Strand M, Numata M, Murakami S, Gaido L, Honda J, Kinney W, Oberley-Deegan R, Voelker D, Ordway D, Chan E
    PLoS ONE, 2013;8(4):e61925.  2013
  57. p62/sequestosome-1 up-regulation promotes ABT-263-induced caspase-8 aggregation/activation on the autophagosome.
    Authors: Huang, Shengbin, Okamoto, Koichi, Yu, Chunrong, Sinicrope, Frank A
    J Biol Chem, 2013;288(47):33654-66.  2013
  58. PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
    Authors: Shin H, You B, Park W
    Oncol Lett, 2013;6(6):1804-1810.  2013
  59. Zoledronic acid significantly enhances radiationinduced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
    Authors: Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S
    Int J Oncol, 2013;42(2):525-34.  2013
  60. Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals.
    Authors: Schoenmann Z, Assa-Kunik E, Tiomny S, Minis A, Haklai-Topper L, Arama E, Yaron A
    J. Neurosci., 2010;30(18):6375-86.  2010
  61. Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
    Authors: Liang X, Moseman EA, Farrar MA
    Blood, 2010;115(24):5041-52.  2010
  62. AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
    Authors: Vucicevic L, Misirkic M, Janjetovic K, Harhaji-Trajkovic L, Prica M, Stevanovic D, Isenovic E, Sudar E, Sumarac-Dumanovic M, Micic D, Trajkovic V
    Biochem. Pharmacol., 2009;77(11):1684-93.  2009
  63. Apoptotic signaling induces hyperpermeability following hemorrhagic shock.
    Authors: Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X
    Am. J. Physiol. Heart Circ. Physiol., 2007;292(6):H3179-89.  2007
  64. Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.
    Authors: Park EJ, Zhao YZ, Kim YC, Sohn DH
    Eur. J. Pharmacol., 2007;559(2):115-23.  2007
  65. Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival.
    Authors: Taylor AR, Gifondorwa DJ, Newbern JM, Robinson MB, Strupe JL, Prevette D, Oppenheim RW, Milligan CE
    J. Neurosci., 2007;27(3):634-44.  2007
  66. Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D.
    Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
    J. Biol. Chem., 2006;281(32):22503-16.  2006
  67. Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases.
    Authors: Conde de la Rosa L, Schoemaker MH, Vrenken TE, Buist-Homan M, Havinga R, Jansen PL, Moshage H
    J. Hepatol., 2006;44(5):918-29.  2006
  68. Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
    Authors: Lee SC, Chan J, Clement MV, Pervaiz S
    Proteomics, 2006;6(8):2386-94.  2006
  69. Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3.
    Authors: Lane D, Cote M, Grondin R, Couture MC, Piche A
    Mol. Cancer Ther., 2006;5(3):509-21.  2006
  70. Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor.
    Authors: Shah N, Asch RJ, Lysholm AS, Lebien TW
    Blood, 2004;104(9):2873-8.  2004
  71. RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
    Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
    Blood, 2004;103(11):4180-7.  2004
  72. Increased sensitivity of early apoptotic cells to complement-mediated lysis.
    Authors: Attali G, Gancz D, Fishelson Z
    Eur. J. Immunol., 2004;34(11):3236-45.  2004
  73. NuMA and nuclear lamins behave differently in Fas-mediated apoptosis.
    Authors: Taimen P, Kallajoki M
    J. Cell. Sci., 2003;116(0):571-83.  2003
  74. Apaf-1 is a mediator of E2F-1-induced apoptosis.
    Authors: Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
    J. Biol. Chem., 2002;277(42):39760-8.  2002
  75. Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.
    Authors: Yang D, He Y, Munoz-Planillo R, Liu Q, Nunez G
    Immunity, 0;43(5):923-32.  0


  1. Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?

    • Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.

  2. Are R&D Systems Caspase Inhibitors irreversible?

    • Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.

      R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.

View all Peptide FAQs

Reviews for Caspase-3 Inhibitor Z-DEVD-FMK

There are currently no reviews for this product. Be the first to review Caspase-3 Inhibitor Z-DEVD-FMK and earn rewards!

Have you used Caspase-3 Inhibitor Z-DEVD-FMK?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review