Caspase-4 Inhibitor Z-YVAD-FMK
Caspase-4 Inhibitor Z-YVAD-FMK Summary
Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.
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Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7).
Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.
Citations for Caspase-4 Inhibitor Z-YVAD-FMK
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 10
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Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis
Authors: T Kobayashi, A Mitsuhashi, P Hongying, M Shioya, K Kojima, K Nishikimi, K Yahiro, M Shozu
Scientific Reports, 2022;12(1):11123. 2022
Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease
Authors: G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo
Cell Rep, 2020;31(13):107839. 2020
Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells
Authors: Q Zhong, TI Roumelioti, Z Kozik, M Cepeda-Mol, LÁ Fernández, AR Shenoy, C Bakal, G Frankel, JS Choudhary
PloS Biology, 2020;18(12):e3000986. 2020
The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
EBioMedicine, 2020;60(0):102984. 2020
PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway
Authors: JH Baek, HS Yun, GT Kwon, J Lee, JY Kim, Y Jo, JM Cho, CW Lee, JY Song, J Ahn, JS Kim, EH Kim, SG Hwang
Cell Death Dis, 2019;10(3):156. 2019
Corticosterone Preexposure Increases NF-?B Translocation and Sensitizes IL-1? Responses in BV2 Microglia-Like Cells
Authors: J Liu, S Mustafa, DT Barratt, MR Hutchinson
Front Immunol, 2018;9(0):3. 2018
Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1? production
Authors: AC Tang, SM Rahavi, SY Fung, HY Lu, H Yang, CJ Lim, GS Reid, SE Turvey
Cell Death Dis, 2018;9(2):162. 2018
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
Authors: L Freeman, H Guo, CN David, WJ Brickey, S Jha, JP Ting
J. Exp. Med., 2017;0(0):. 2017
Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activity
Authors: E Naschberge, W Gei beta dörfer, C Bogdan, P Tripal, E Kremmer, M Stürzl, N Britzen-La
J. Cell. Mol. Med, 2017;0(0):. 2017
Production and regulation of interleukin-1 family cytokines at the materno-fetal interface
Authors: LM Scott, AH Bryant, A Rees, B Down, RH Jones, CA Thornton
Cytokine, 2017;0(0):. 2017
Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific
Authors: N Nishijima, T Hirai, K Misato, M Aoyama, E Kuroda, KJ Ishii, K Higashisak, Y Yoshioka, Y Tsutsumi
Front Immunol, 2017;8(0):379. 2017
IL-1? is an innate immune sensor of microbial proteolysis
Authors: CN LaRock, J Todd, DL LaRock, J Olson, AJ O'Donoghue, AA Robertson, MA Cooper, HM Hoffman, V Nizet
Sci Immunol, 2016;1(2):. 2016
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
Nat Commun, 2016;7(0):13292. 2016
Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
Authors: Gonzalez-Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, Dube P, Bergman M, Orihuela C
PLoS Pathog, 2015;11(12):e1005337. 2015
A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury.
Authors: Whidbey C, Vornhagen J, Gendrin C, Boldenow E, Samson J, Doering K, Ngo L, Ezekwe E, Gundlach J, Elovitz M, Liggitt D, Duncan J, Adams Waldorf K, Rajagopal L
EMBO Mol Med, 2015;7(4):488-505. 2015
Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
PLoS ONE, 2015;10(8):e0136708. 2015
Inflammasome activation in response to the Yersinia type III secretion system requires hyperinjection of translocon proteins YopB and YopD.
Authors: Zwack E, Snyder A, Wynosky-Dolfi M, Ruthel G, Philip N, Marketon M, Francis M, Bliska J, Brodsky I
MBio, 2015;6(1):e02095-14. 2015
Extracorporeal photopheresis promotes IL-1beta production.
Authors: Yakut E, Jakobs C, Peric A, Michel G, Baal N, Bein G, Brune B, Hornung V, Hackstein H
J Immunol, 2015;194(6):2569-77. 2015
Spleen Tyrosine Kinase (Syk) Mediates IL-1beta Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.
Authors: Callaway J, Smith S, McKinnon K, de Silva A, Crowe J, Ting J
J Biol Chem, 2015;290(28):17306-20. 2015
BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress.
Authors: Roulstone V, Pedersen M, Kyula J, Mansfield D, Khan A, McEntee G, Wilkinson M, Karapanagiotou E, Coffey M, Marais R, Jebar A, Errington-Mais F, Melcher A, Vile R, Pandha H, McLaughlin M, Harrington K
Mol Ther, 2015;23(5):931-42. 2015
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.
Authors: Li Q, Yokoshi M, Okada H, Kawahara Y
Nat Commun, 2015;6(0):6183. 2015
Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity.
Authors: Teigler J, Kagan J, Barouch D
J Virol, 2014;88(18):10354-63. 2014
Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells.
Authors: McCloy R, Shelley E, Roberts C, Boslem E, Biden T, Nicholson R, Gee J, Sutherland R, Musgrove E, Burgess A, Butt A
Br J Cancer, 2013;109(12):3034-41. 2013
Increased sensitivity of early apoptotic cells to complement-mediated lysis.
Authors: Attali G, Gancz D, Fishelson Z
Eur. J. Immunol., 2004;34(11):3236-45. 2004
Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells.
Authors: Edgeworth JD, Spencer J, Phalipon A, Griffin GE, Sansonetti PJ
Eur. J. Immunol., 2002;32(5):1464-71. 2002
Does R&D Systems offer a negative control for Caspase Inihibitors with benzyloxycarbonyl group (Z-) at the N-terminus and the FMK functional group at the C-terminus?
Yes, R&D Systems offers Caspase Inhibitor Control Z-FA-FMK, Catalog # FMKC01, which is an inhibitor of cathepsins B and L but not caspases, and has been used in several systems as a negative control for peptide inhibitors of caspases.
Are R&D Systems Caspase Inhibitors irreversible?
Yes, the majority of R&D Systems Caspase Inhibitors have a Fluoromethyl ketone (FMK) functional group on the C-terminus of the peptide, and act as effective irreversible inhibitors with no added cytotoxic effects. Inhibitors synthesized with a benzyloxycarbonyl group (also known as BOC or Z) at the N-terminus and O-methyl side chains exhibit enhanced cellular permeability.
R&D Systems also offers a General Caspase Inhibitor, Q-VD-OPh, Catalog # OPH001, as well as a FITC-conjugated pan-caspase inhibitor (ApoStat), Catalog # FMK012, which are both cell-permeable, irreversible inhibitors of caspase activity.
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