Catalog Number: 0759
Chemical Name: [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol
Biological Activity
Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
    Gruters et al.
    Nature, 1987;330:74
  2. Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
    Welker et al.
    Proc.Natl.Acad.Sci.U.S.A., 1987;84:8120
  3. Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases.
    Saul et al.
    Arch.Biochem.Biophys., 1984;230:668
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