Chemical Name: [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol
Biological ActivityCastanospermine is a potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.
Gruters et al.
Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases.
Saul et al.
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine.
Welker et al.
Citation for Castanospermine
The citations listed below are publications that use Tocris products. Selected citations for Castanospermine include:
1 Citation: Showing 1 - 1
The antifungal drug itracon. inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells.
Authors: Nacev Et al.
J Biol Chem 2011;286:44045
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