CC 0651
Chemical Name: (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
Purity: ≥98%
Biological Activity
Allosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.Technical Data
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
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An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
Ceccarelli et al.
Cell, 2011;145:1075 -
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Huang et al.
Nat.Chem.Biol., 2014;10:156
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Citation for CC 0651
The citations listed below are publications that use Tocris products. Selected citations for CC 0651 include:
1 Citation: Showing 1 - 1
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σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
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