Allosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1
= 1.72 μ
M). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.
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An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
Ceccarelli et al.
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Huang et al.