Catalog Number: 4503
Chemical Name: (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
Biological Activity
Allosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.
Technical Data
  • M.Wt:
    442.29
  • Formula:
    C20H21Cl2NO6
  • Solubility:
    Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1319207-44-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
    Ceccarelli et al.
    Cell, 2011;145:1075
  2. E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
    Huang et al.
    Nat.Chem.Biol., 2014;10:156

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