Chemical Name: (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid
Biological ActivityAllosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
Ceccarelli et al.
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Huang et al.
Citation for CC 0651
The citations listed below are publications that use Tocris products. Selected citations for CC 0651 include:
1 Citation: Showing 1 - 1
σ1 receptor ligands control a switch between passive and active threat responses.
Authors: Rennekamp Et al.
Nat Chem Biol 2016;12:552
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