Catalog Number: 6258
Chemical Name: 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole dihydrochloride
Biological Activity
High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication.
Technical Data
  • M.Wt:
    461.39
  • Formula:
    C22H24N6O.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. JNK mediates hepatic ischemia reperfusion injury.
    Uehara et al.
    J.Hepatol., 2005;42:850
  2. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis.
    Ma et al.
    J.Am.Soc.Nephrol., 2007;18:472
  3. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat.
    Ma et al.
    Lab.Invest., 2009;89:470
  4. The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication.
    Zhang et al.
    J.Med.Virol., 2015;87:2135
  5. Inhibition of JNK sensitizes hypoxic colon cancer cells to DNA-damaging agents.
    Vasilevskaya et al.
    Clin.Cancer.Res., 2015;21:4143
  6. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation.
    Uehara et al.
    Transplantation., 2004;78:324
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