CC 401 dihydrochloride

Key Product Details

Product Description

CC 401 dihydrochloride is a high affinity JNK inhibitor (K_i values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication.

Product Specifications for CC 401 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CC 401 dihydrochloride

The following data is based on the product molecular weight 461.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.84 mL	21.67 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Vasilevskaya Inhibition of JNK sensitizes hypoxic colon cancer cells to DNA-damaging agents. Clin.Cancer.Res. 2015 PMID: 26023085
• Zhang The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication. J.Med.Virol. 2015 PMID: 26058558
• Ma Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab.Invest. 2009 PMID: 19188913
• Ma A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J.Am.Soc.Nephrol. 2007 PMID: 17202416
• Uehara JNK mediates hepatic ischemia reperfusion injury. J.Hepatol. 2005 PMID: 15885356
• Uehara c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 2004 PMID: 15316358

Product Documents for CC 401 dihydrochloride