Catalog Number: 4567
Chemical Name: 4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
Biological Activity
Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein (IC50 values are 30.1 nM and 11.0 μM for RGS4 and RGS8 respectively). Exhibits >20-fold selectivity for RGS4 over other RGS proteins.
Technical Data
  • M.Wt:
    316.35
  • Formula:
    C16H13FN2O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    883050-24-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Conformational dynamics of a regulator of g-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule.
    Vashisth et al.
    ACS Chem.Biol., 2013;8:2778
  2. A nanomolar potency small molecule inhibitor of regulator of G protein signaling (RGS) proteins.
    Blazer et al.
    Biochemistry, 2011;50:3181
  3. Small molecule inhibitors of regulators of G protein signalling (RGS) proteins.
    Turner et al.
    ACS Med.Chem.Lett., 2012;3:146

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