CCG 50014
Discontinued Product
Chemical Name: 4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
Purity: ≥98%
Biological Activity
CCG 50014 is a potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein (IC50 values are 30.1 nM and 11.0 μM for RGS4 and RGS8 respectively). Exhibits >20-fold selectivity for RGS4 over other RGS proteins.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Conformational dynamics of a regulator of g-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule.
Vashisth et al.
ACS Chem.Biol., 2013;8:2778 -
A nanomolar potency small molecule inhibitor of regulator of G protein signaling (RGS) proteins.
Blazer et al.
Biochemistry, 2011;50:3181 -
Small molecule inhibitors of regulators of G protein signalling (RGS) proteins.
Turner et al.
ACS Med.Chem.Lett., 2012;3:146
Product Datasheets
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Citation for CCG 50014
The citations listed below are publications that use Tocris products. Selected citations for CCG 50014 include:
1 Citation: Showing 1 - 1
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Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex.
Authors: Kee K Et al.
Dis Model Mech 2022;15
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