Cdx1 Antibody - BSA Free

Novus Biologicals | Catalog # NBP2-49173

Novus Biologicals
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all CDX1 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: VGYVLDKDSPVYPGPARPASLGLGPQAY

Reactivity Notes

Mouse (89%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cdx1 Antibody - BSA Free

Immunohistochemistry-Paraffin: Cdx1 Antibody [NBP2-49173]

Immunohistochemistry-Paraffin: Cdx1 Antibody [NBP2-49173]

Immunohistochemistry-Paraffin: Cdx1 Antibody [NBP2-49173] - Staining of human rectum shows high expression.
Immunohistochemistry-Paraffin: Cdx1 Antibody [NBP2-49173]

Immunohistochemistry-Paraffin: Cdx1 Antibody [NBP2-49173]

Immunohistochemistry-Paraffin: Cdx1 Antibody [NBP2-49173] - Staining of human liver shows low expression as expected.
Immunohistochemistry-Paraffin: Cdx1 Antibody [NBP2-49173]

Immunohistochemistry-Paraffin: Cdx1 Antibody [NBP2-49173]

Immunohistochemistry-Paraffin: Cdx1 Antibody [NBP2-49173] - Staining in human rectum and liver tissues using anti-CDX1 antibody. Corresponding CDX1 RNA-seq data are presented for the same tissues.

Applications for Cdx1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CDX1

The transcription factors Cdx1 and Cdx2 are members of the caudal-related homeobox gene family based on their homology to the factor caudal in Drosophila melanogaster. The caudal homeobox factor is required for anterior-posterior regional identity and axial patterning in Drosophila. During mouse development, the expression of Cdx1 and Cdx2 can be divided into two stages that likely reflect distinct roles. During early development, these two factors are expressed in a Hox-like manner in the three germ layers and appear to have overlapping functions in anterior-posterior patterning and posterior axis elongation. The second stage of Cdx1 and Cdx2 expression, from late development into adulthood, is characterized by the loss of expression almost everywhere but the epithelium of small intestine and colon. Putative intestine-specific enhancers upstream of the CDX1 gene have been identified that may orchestrate the switch in expression patterns for that gene. As might be expected from this pattern of expression, a wide variety of in vivo and in vitro studies have suggested that these two factors are important in controlling epithelial cell differentiation, proliferation, and function in the intestine.

Long Name

Caudal-type Homeobox Transcription Factor 1

Alternate Names

caudal type homeo box transcription factor 1, caudal type homeobox 1, caudal type homeobox transcription factor 1, Caudal-type homeobox protein 1, caudal-type homeobox protein CDX1, homeobox protein CDX-1, MGC116915

Gene Symbol

CDX1

Additional CDX1 Products

Product Documents for Cdx1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Cdx1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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