Ceftriaxone disodium salt
Chemical Name: 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
Biological Activityβ-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.
Rothstein et al.
The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats.
Rawls et al.
Neuroprotective potential of ceftri. in in vitro models of stroke.
Lipski et al.
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VersaClone cDNA Plasmids
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Added to cells in vitro
Used it to increase protein expression of GLT1 in mouse brain. It worked very well and easily dissolves in saline.