Ceftriaxone disodium salt
Discontinued Product
Chemical Name: 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
Purity: ≥98%
Biological Activity
β-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.
Rothstein et al.
Nature, 2005;433:73 -
The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats.
Rawls et al.
Br.J.Pharmacol., 2007;151:1095 -
Neuroprotective potential of ceftri. in in vitro models of stroke.
Lipski et al.
Neuroscience, 2007;146:617
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