Catalog Number: 3732
Chemical Name: 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt
Biological Activity
β-lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.
    Rothstein et al.
    Nature, 2005;433:73
  2. The beta-lactam antibiotic, ceftriaxone, attenuates morphine-evoked hyperthermia in rats.
    Rawls et al.
    Br.J.Pharmacol., 2007;151:1095
  3. Neuroprotective potential of ceftriaxone in in vitro models of stroke.
    Lipski et al.
    Neuroscience, 2007;146:617
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