Chemical Name: 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid
Biological ActivityPotent, selective GABAB receptor antagonist (IC50 = 85 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
GABAB receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord.
Bonanno et al.
Blockade of GABAB receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro.
Libri et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1998;358:168
CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex.
Lanza et al.
Potent, orally active GABAB receptor antagonists.
Froestl et al.
Citations for CGP 52432
The citations listed below are publications that use Tocris products. Selected citations for CGP 52432 include:
22 Citations: Showing 1 - 10
Presynaptic mGlu1 Receptors Control GABAB Receptors in an Antagonist-Like Manner in Mouse Cortical GABAergic and Glutamatergic Nerve Endings.
Authors: Vergassola Et al.
Front Mol Neurosci 2018;11:324
Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels
Authors: Sargin Et al.
Vasculo-neuronal coupling: retrograde vascular communication to brain neurons
Authors: Jung Kim Et al.
The Journal of Neuroscience 2016;14:12624
Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.
Authors: Bragina Et al.
Front Cell Neurosci 2015;9:345
Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
Authors: Lee Et al.
Neural Plast 2015;2015:924728
Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
Authors: Dobson Et al.
J Pharmacol Exp Ther 2015;10:e0125974
An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
Authors: Mans Et al.
J Neurophysiol 2014;112:2388
Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
Authors: Song Et al.
Front Cell Neurosci 2013;7:23
PropF. inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.
Authors: Yang Et al.
J Immunol 2013;190:6511
Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus.
Authors: Venkataraman and Bartlett
J Neurophysiol 2013;109:2866
The role of inhibition in oscillatory wave dynamics in the cortex.
Authors: Xiao Et al.
Eur J Neurosci 2012;36:2201
Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
Authors: Marrocco Et al.
PLoS One 2012;32:17143
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
Authors: Chacón Et al.
J Neurosci 2012;139:3200
Synergistic activation of DA D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala.
Authors: Li Et al.
PLoS One 2011;6:e26065
Attenuating GABA(A) receptor signaling in DA neurons selectively enhances reward learning and alters risk preference in mice.
Authors: Parker Et al.
J Neurosci 2011;31:17103
Leptin does not directly affect CNS serotonin neurons to influence appetite.
Authors: Lam Et al.
J Physiol 2011;13:584
Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
Authors: Adedoyin Et al.
Mol Pain 2010;6:60
Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption.
Authors: Wu Et al.
Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors.
Authors: Moore Et al.
The role of protein kinase A in the ethanol-induced increase in spontaneous GABA release onto cerebellar Purkinje neurons.
Authors: Kelm Et al.
J Neurophysiol 2008;100:3417
Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3.
Authors: Jensen Et al.
J Neurochem 2007;579:85
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