CGP 52432

  ( 17 citations )    
Product Datasheet
Catalog Number:1246
Chemical Name:3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid
Product Details
Citations (17)
Supplemental Products
Reviews
Biological Activity
Potent, selective GABAB receptor antagonist (IC50 = 85 nM).
Technical Data
  • M.Wt:
    384.24
  • Formula:
    C15H24Cl2NO4P
  • Solubility:
    Soluble to 10 mM in water with sonication
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    139667-74-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 52432 include:

17 Citations: Showing 1 - 10
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  1. Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels
    Authors: Sargin Et al.
    Elife  2016;5:e21416
  2. Vasculo-neuronal coupling: retrograde vascular communication to brain neurons
    Authors: Jung Kim Et al.
    The Journal of Neuroscience  2016;14:12624
  3. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.
    Authors: Bragina Et al.
    Front Cell Neurosci  2015;9:345
  4. Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
    Authors: Lee Et al.
    Neural Plast  2015;2015:924728
  5. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Pharmacol Exp Ther  2015;10:e0125974
  6. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
    Authors: Mans Et al.
    J Neurophysiol  2014;112:2388
  7. Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
    Authors: Song Et al.
    Front Cell Neurosci  2013;7:23
  8. Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus.
    Authors: Venkataraman and Bartlett
    J Neurophysiol  2013;109:2866
  9. The role of inhibition in oscillatory wave dynamics in the cortex.
    Authors: Xiao Et al.
    Eur J Neurosci  2012;36:2201
  10. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
    Authors: Marrocco Et al.
    PLoS One  2012;32:17143
  11. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep  2012;2:285
  12. Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
    Authors: Chacón Et al.
    J Neurosci  2012;139:3200
  13. Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice.
    Authors: Parker Et al.
    J Neurosci  2011;31:17103
  14. Leptin does not directly affect CNS serotonin neurons to influence appetite.
    Authors: Lam Et al.
    J Physiol  2011;13:584
  15. Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption.
    Authors: Wu Et al.
    Development  2010;115:1112
  16. Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors.
    Authors: Moore Et al.
    Neuron  2009;61:287
  17. Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3.
    Authors: Jensen Et al.
    J Neurochem  2007;579:85
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