Catalog Number: 1246
Chemical Name: 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid
Biological Activity
Potent, selective GABAB receptor antagonist (IC50 = 85 nM).
Technical Data
  • M.Wt:
    384.24
  • Formula:
    C15H24Cl2NO4P
  • Solubility:
    Soluble to 10 mM in water with sonication
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    139667-74-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Background References
  1. GABAB receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord.
    Bonanno et al.
    Eur.J.Pharmacol., 1998;362:143
  2. Blockade of GABAB receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro.
    Libri et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1998;358:168
  3. CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex.
    Lanza et al.
    Eur.J.Pharmacol., 1993;237:191
  4. Potent, orally active GABAB receptor antagonists.
    Froestl et al.
    Pharmacol.Rev.Comm., 1996;8:127
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CGP 52432 include:

16 Citations: Showing 1 - 10
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  1. Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels
    Authors: Sargin Et al.
    Elife 2016;5:e21416
  2. Vasculo-neuronal coupling: retrograde vascular communication to brain neurons
    Authors: Jung Kim Et al.
    The Journal of Neuroscience 2016;14:12624
  3. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.
    Authors: Bragina Et al.
    Front Cell Neurosci 2015;9:345
  4. Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
    Authors: Lee Et al.
    Neural Plast 2015;2015:924728
  5. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Pharmacol Exp Ther 2015;10:e0125974
  6. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
    Authors: Mans Et al.
    J Neurophysiol 2014;112:2388
  7. Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
    Authors: Song Et al.
    Front Cell Neurosci 2013;7:23
  8. Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus.
    Authors: Venkataraman and Bartlett
    J Neurophysiol 2013;109:2866
  9. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
    Authors: Marrocco Et al.
    PLoS One 2012;32:17143
  10. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep 2012;2:285
  11. Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
    Authors: Chacón Et al.
    J Neurosci 2012;139:3200
  12. Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice.
    Authors: Parker Et al.
    J Neurosci 2011;31:17103
  13. Leptin does not directly affect CNS serotonin neurons to influence appetite.
    Authors: Lam Et al.
    J Physiol 2011;13:584
  14. Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption.
    Authors: Wu Et al.
    Development 2010;115:1112
  15. Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors.
    Authors: Moore Et al.
    Neuron 2009;61:287
  16. Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3.
    Authors: Jensen Et al.
    J Neurochem 2007;579:85
Expand to show all 16 Citations

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