CGP 52432

Tocris Bioscience | Catalog # 1246

Potent and selective GABAB antagonist
Tocris Bioscience

Key Product Details

Description

Potent and selective GABAB antagonist
View all GABA-B Receptor Antagonists »

Product Description

CGP 52432 is a potent, selective GABAB receptor antagonist (IC50 = 85 nM).

Licensing Information

Sold with the permission of Novartis Pharma AG

Product Specifications for CGP 52432

Molecular Weight

384.24

Formula

C15H24Cl2NO4P

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid

CAS Number

139667-74-6

PubChem ID

132252

InChI Key

GJZVQXWEIYRHBE-UHFFFAOYSA-N

SMILES

ClC1=CC=C(CNCCCP(C(OCC)OCC)(O)=O)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.92 5

Preparing Stock Solutions for CGP 52432

The following data is based on the product molecular weight 384.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 52.05 mL 260.25 mL 520.51 mL
0.25 mM 10.41 mL 52.05 mL 104.10 mL
0.5 mM 5.21 mL 26.03 mL 52.05 mL
2.5 mM 1.04 mL 5.21 mL 10.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 174 publications citing the usage of this product.

Product Documents for CGP 52432

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for CGP 52432

For research use only

Customer Reviews for CGP 52432 (1)

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  • Stimulation of epileptiform activity
    Name: Sergiy Sylantyev
    Species: Rat
    Assay Type: Ex Vivo
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 12/10/2023
    CGP 52432 in high concentration was used to shape epileptiform activity in hippocampal brain tissue. Figure: patterned epileptiform activity (top trace) with synchronized neurotransmitter release (medium trace) from acute hippocampal tissue with high concentration (5 microM) of CGP in perfusion solution.
    CGP 52432 1246

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