Catalog Number: 1246
Chemical Name: 3-[[(3,4-Dichlorophenyl)methyl]amino]propyl] diethoxymethyl)phosphinic acid
Biological Activity
Potent, selective GABAB receptor antagonist (IC50 = 85 nM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in water with sonication and to 100 mM in 1eq. NaOH
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Background References
  1. GABAB receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord.
    Bonanno et al.
    Eur.J.Pharmacol., 1998;362:143
  2. Blockade of GABAB receptors facilitates muscarinic agonist-induced epileptiform activity in immature rat piriform cortex in vitro.
    Libri et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1998;358:168
  3. CGP 52432: a novel potent and selective GABAB autoreceptor antagonist in rat cerebral cortex.
    Lanza et al.
    Eur.J.Pharmacol., 1993;237:191
  4. Potent, orally active GABAB receptor antagonists.
    Froestl et al.
    Pharmacol.Rev.Comm., 1996;8:127

The citations listed below are publications that use Tocris products. Selected citations for CGP 52432 include:

Showing Results 1 - 10 of 14

  1. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals.
    Authors: Bragina Et al.
    Front Cell Neurosci
  2. Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat.
    Authors: Lee Et al.
    Neural Plast
  3. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Pharmacol Exp Ther
  4. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats.
    Authors: Mans Et al.
    J Neurophysiol
  5. Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
    Authors: Song Et al.
    Front Cell Neurosci
  6. Postnatal development of synaptic properties of the GABAergic projection from the inferior colliculus to the auditory thalamus.
    Authors: Venkataraman and Bartlett
    J Neurophysiol
  7. Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus.
    Authors: Marrocco Et al.
    PLoS One
  8. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep
  9. Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
    Authors: Chacón Et al.
    J Neurosci
  10. Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice.
    Authors: Parker Et al.
    J Neurosci
  11. Leptin does not directly affect CNS serotonin neurons to influence appetite.
    Authors: Lam Et al.
    J Physiol
  12. Correlated changes in NMDA receptor phosphorylation, functional activity, and sedation by chronic ethanol consumption.
    Authors: Wu Et al.
  13. Plasticity of burst firing induced by synergistic activation of metabotropic glutamate and acetylcholine receptors.
    Authors: Moore Et al.
  14. Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3.
    Authors: Jensen Et al.
    J Neurochem
Expand to show all
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