Catalog Number: 1088
Chemical Name: [S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid
Biological Activity
A potent, selective GABAB receptor antagonist (IC50 = 4 nM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Background References
  1. The action of new potent GABAB receptor antagonists in the hemisected spinal cord preparation of the rat.
    Brugger et al.
    Eur.J.Pharmacol., 1993;235:153
  2. GABAB-receptor subtypes assemble into functional heteromeric complexes.
    Kaupmann et al.
    Nature, 1998;396:683
  3. Potent, orally active GABAB receptor antagonists.
    Froestl et al.
    Pharmacol.Rev.Comm., 1996;8:127

The citations listed below are publications that use Tocris products. Selected citations for CGP 54626 hydrochloride include:

Showing Results 1 - 10 of 17

  1. GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
    Authors: Zhang Et al.
  2. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation.
    Authors: Chen Et al.
    J Neurosci
  3. Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
    Authors: Bocchio Et al.
  4. GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner.
    Authors: Kotecki Et al.
    Proc Natl Acad Sci U S A
  5. Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons.
    Authors: Pfeffer Et al.
    Nat Neurosci
  6. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
    Authors: Baloucoune Et al.
    PLoS One
  7. A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy.
    Authors: Paz Et al.
    Proc Natl Acad Sci U S A
  8. PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons.
    Authors: Werner Et al.
    J Biol Chem
  9. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
    Authors: Tu Et al.
    J Neurosci
  10. Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice.
    Authors: Tani Et al.
    J Neurosci
  11. Serotonin modulates olfactory processing in the antennal lobe of Drosophila.
    Authors: Dacks Et al.
    Nat Neurosci
  12. Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.
    Authors: Ignell Et al.
    Br J Pharmacol
  13. A presynaptic gain control mechanism fine-tunes olfactory behavior.
    Authors: Root Et al.
  14. Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors.
    Authors: Binet Et al.
    J Neurogenet
  15. Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
    Authors: Piet Et al.
    Br J Pharmacol
  16. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence.
    Authors: Dzitoyeva Et al.
    Proc Natl Acad Sci U S A
  17. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    J Neurochem
Expand to show all
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information

Molarity Calculator
Calculate the mass, volume or concentration required for a solution

The molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol)
An example of a molarity calculation using the molarity calculator:
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?

R&D Systems Guarantee

or select another batch:


Customer Information