CGP 54626 hydrochloride

  ( 27 citations )    
Product Datasheet
Catalog Number:1088
Chemical Name:[S-(R*,R*)]-[3-[[1-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropyl](cyclohexylmethyl) phosphinic acid
Product Details
Citations (27)
Supplemental Products
Biological Activity
A potent, selective GABAB receptor antagonist (IC50 = 4 nM).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Product Datasheets

The citations listed below are publications that use Tocris products. Selected citations for CGP 54626 hydrochloride include:

27 Citations: Showing 1 - 10
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  1. FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor.
    Authors: Lecat-Guillet
    Cell Chem Biol  2017;24(3):360
  2. HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
    Authors: Scholler
    Nat Chem Biol  2017;13(4):372
  3. Functional integration of a serotonergic neuron in the Drosophila antennal lobe.
    Authors: Zhang and Gaudry
    Elife  2016;5
  4. Neuronal splicing regulator RBFOX3(NeuN) regulates adult hippocampal neurogenesis and synaptogenesis
    Authors: Lin Et al.
    PLoS One  2016;11:e0164164
  5. Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy.
    Authors: Chumakov Et al.
    Sci Rep  2015;5:7608
  6. GABAB receptor upregulates fragile X mental retardation protein expression in neurons.
    Authors: Zhang Et al.
    Elife  2015;5:10468
  7. Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
    Authors: Bocchio Et al.
    Neuropsychopharmacology  2015;40:3015
  8. Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation.
    Authors: Chen Et al.
    J Neurosci  2015;4
  9. GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner.
    Authors: Kotecki Et al.
    Proc Natl Acad Sci U S A  2015;35:7131
  10. Modification of Male Courtship Motivation by Olfactory Habituation via the GABAA Receptor in Drosophila melanogaster.
    Authors: Tachibana Et al.
    PLoS One  2015;10:e0135186
  11. Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors.
    Authors: Zhang Et al.
    PLoS One  2013;8:e66122
  12. Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons.
    Authors: Pfeffer Et al.
    Nat Neurosci  2013;16:1068
  13. GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation.
    Authors: Baloucoune Et al.
    PLoS One  2012;7:e39698
  14. A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy.
    Authors: Paz Et al.
    Proc Natl Acad Sci U S A  2011;14:1167
  15. PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons.
    Authors: Werner Et al.
    J Biol Chem  2011;116:554
  16. Specializations of a pheromonal glomerulus in the Drosophila olfactory system.
    Authors: Agarwal and Isacoff
    J Neurophysiol  2011;105:1711
  17. GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.
    Authors: Tu Et al.
    J Neurosci  2010;30:749
  18. Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice.
    Authors: Tani Et al.
    J Neurosci  2010;30:1288
  19. ATP-dependent infra-slow (0.1 Hz) oscillations in thalamic networks.
    Authors: Lörincz Et al.
    PLoS One  2009;4:e4447
  20. Serotonin modulates olfactory processing in the antennal lobe of Drosophila.
    Authors: Dacks Et al.
    Nat Neurosci  2009;23:366
  21. Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila.
    Authors: Ignell Et al.
    Br J Pharmacol  2009;106:13070
  22. A presynaptic gain control mechanism fine-tunes olfactory behavior.
    Authors: Root Et al.
    Neuron  2008;59:311
  23. Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors.
    Authors: Binet Et al.
    J Neurogenet  2007;282:12154
  24. Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe.
    Authors: Shang Et al.
    Cell  2007;128:601
  25. Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
    Authors: Piet Et al.
    Br J Pharmacol  2004;101:2151
  26. Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence.
    Authors: Dzitoyeva Et al.
    Proc Natl Acad Sci U S A  2003;100:5485
  27. The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.
    Authors: Wood Et al.
    J Neurochem  2000;131:1050
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