CGP 55845 hydrochloride
Tocris Bioscience | Catalog # 1248
Key Product Details
Description
Product Description
CGP 55845 hydrochloride is a potent, selective GABAB receptor antagonist (IC50 = 5 nM) that prevents agonist binding (pKi = 8.35) and inhibits GABA and glutamate release (pEC50 values are 8.08 and 7.85 respectively). Inhibits GABAB responses to baclofen (IC50 = 130 nM in an isoproterenol assay) and potentiates the hypoglycemic response to glucose in vitro.Licensing Information
Sold with the permission of Novartis Pharma AG
Product Specifications for CGP 55845 hydrochloride
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.87 | 100 with gentle warming |
Preparing Stock Solutions for CGP 55845 hydrochloride
The following data is based on the product molecular weight 438.71.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.40 mL | 22.79 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 140 publications citing the usage of this product.
- Froestl Potent, orally active GABAB receptor antagonists. Pharmacol.Rev.Comm.
- Zhang Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. J.Physiol. 2007 PMID: 17124268
- Waldmeier GABA and glutamate release affected by GABAB receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors. Br.J.Pharmacol. 1994 PMID: 7889310
- Salah and Perkins Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices. Neuropharmacology 2008 PMID: 18538357
- Deisz The GABAB antagonist CGP 55845A reduces presynaptic GABA1 actions in neurons of the rat in vitro. Neuroscience 1999 PMID: 10501448
- Cunninghan and Enna Evidence for pharmacologically distinct GABAB receptors associated with cAMP production in rat brain. Brain Res. 1996 PMID: 8782915
Product Documents for CGP 55845 hydrochloride
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for CGP 55845 hydrochloride
For research use only
Related Research Areas
Citations for CGP 55845 hydrochloride
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Species: RatAssay Type: Ex VivoCell Line/Tissue: Anterior cingulate cortexVerified Customer | Posted 06/07/2019Should be sonicated when dissolved.CGP-55845 was used to study input of GABA-B receptors into field potential generation in anterior cingulate cortex. Application of 10 nM CGP-55845 increased significantly amplitudes of field potentials and reduced their paired-pulse ratio.
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Species: MouseAssay Type: Ex VivoVerified Customer | Posted 03/28/2018We typically make a 10mM stock solution in DMSO. Drug seems pretty stable.Effects of GABAB activation on electrically stimulated dopamine release in the striatum was measured using fast scan cyclic votlammetry. CGP55845 (200nM) nicely reverse Baclofen (30uM) effects on dopamine release.
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