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CGS 20625

2467 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2467/10
2467/50
GABA-A Receptor Benzodiazepines Small Molecule
1 Image
Description: Selective benzodiazepine partial agonist

Chemical Name: 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one

Purity: ≥99%

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Biological Activity

Selective, partial agonist for the benzodiazepine binding site of the GABAA receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC50 = 0.68 - 2.25 μM) and GABA binding sites (IC50 > 10000 μM). Displays anxiolytic activity in vivo following oral administration..

Technical Data

M.Wt:
309.36
Formula:
C18H19N3O2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
111205-55-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions.
    Bennett
    Physiol.Behav., 1987;41:241
  2. CGS 20625, a novel pyrazolopyridine anxiolytic.
    Williams et al.
    J.Pharmacol.Exp.Ther., 1989;248:89
  3. CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity.
    Jarvis et al.
    Prog.Clin.Biol.Res., 1990;361:477

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