Chemical Name: 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one
Biological ActivitySelective, partial agonist for the benzodiazepine binding site of the GABAA receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC50 = 0.68 - 2.25 μM) and GABA binding sites (IC50 > 10000 μM). Displays anxiolytic activity in vivo following oral administration..
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions.
CGS 20625, a novel pyrazolopyridine anxiolytic.
Williams et al.
CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity.
Jarvis et al.
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