CGS 20625
Chemical Name: 5,6,7,8,9,10-Hexahydro-2-(4-methoxyphenyl)cyclohepta[b]pyrazolo[3,4-d]pyridin-3(2H)-one
Purity: ≥99%
Biological Activity
Selective, partial agonist for the benzodiazepine binding site of the GABAA receptor. Potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC50 = 0.68 - 2.25 μM) and GABA binding sites (IC50 > 10000 μM). Displays anxiolytic activity in vivo following oral administration..Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions.
Bennett
Physiol.Behav., 1987;41:241 -
CGS 20625, a novel pyrazolopyridine anxiolytic.
Williams et al.
J.Pharmacol.Exp.Ther., 1989;248:89 -
CGS 20625, a novel pyrazolopyridine with selective anxiolytic activity.
Jarvis et al.
Prog.Clin.Biol.Res., 1990;361:477
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