Cell-permeable inhibitor of protein kinase C (IC50
= 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL
to Bak (IC50
= 1.5 μ
M) or Bad proteins and stimulates apoptosis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of chelerythrine as an inhibitor of BclXL function.
Chan et al.
Chelerythrine is a potent and specfic inhibitor of protein kinase C.
Herbert et al.
Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C.
Lee et al.
Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C.
Yu et al.
The citations listed below are publications that use Tocris products. Selected citations for Chelerythrine chloride include:
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