Chelerythrine chloride

  ( 15 citations )    
Product Datasheet
Catalog Number:1330
Chemical Name:1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
Product Details
Citations (15)
Reviews
Biological Activity
Cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis.
Technical Data
  • M.Wt:
    383.83
  • Formula:
    C21H18ClNO4
  • Solubility:
    Soluble to 10 mM in water and to 10 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    3895-92-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Chelerythrine chloride include:

15 Citations: Showing 1 - 10
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  1. Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats.
    Authors: Li
    Sci Rep  2017;7(1):15317
  2. Cocaine-seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 dopamine receptor-expressing neurons.
    Authors: Ortinski Et al.
    Neuropharmacology  2015;92:80
  3. Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.
    Authors: Morelli Et al.
    BMC Cancer  2014;14:921
  4. Loss of long-term depression in the insular cortex after tail amputation in adult mice.
    Authors: Liu and Zhuo
    Mol Pain  2014;10:1
  5. Extracellular microvesicles from astrocytes contain functional glutamate transporters: regulation by protein kinase C and cell activation.
    Authors: Gosselin Et al.
    Front Cell Neurosci  2013;7:251
  6. S100A1 deficiency impairs postischemic angiogenesis via compromised proangiogenic endothelial cell function and nitric oxide synthase regulation.
    Authors: Most Et al.
    Circ Res  2013;112:66
  7. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit.
    Authors: Cho Et al.
    J Neurosci  2012;32:14165
  8. Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus.
    Authors: Mockett Et al.
    J Neurosci  2011;31:7380
  9. mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.
    Authors: Chen Et al.
    J Biomed Sci  2011;18:19
  10. Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction.
    Authors: Song Et al.
    ACS Chem Neurosci  2010;85:614
  11. Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
    Authors: Fuortes Et al.
    Epilepsia  2010;51:1633
  12. The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV(1) in primary afferent neurons evoked by intradermal capsaicin.
    Authors: Xu Et al.
    Exp Neurol  2010;222:93
  13. Involvement of protein kinase C in morphine tolerance at spinal levels of rats.
    Authors: Jin and Yu
    Autophagy  2010;1:122
  14. Increases in transient receptor potential vanilloid-1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation.
    Authors: Xu Et al.
    Cardiovasc Res  2009;87:482
  15. Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance.
    Authors: Xie and Wang
    Hypertension  2009;54:1298
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