Catalog Number: 2952
Alternate Names: N-acetyldinaline
Chemical Name: 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Biological Activity
Orally active class I histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.
    Beckers et al.
    Int.J.Cancer, 2007;121:1138
  2. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.
    Gr?ff et al.
    Cell, 2014;156:261
  3. Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma.
    Kraker et al.
    Mol.Cancer Ther., 2003;2:401

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