Orally active class I histone deacetylase (HDAC) inhibitor (Ki
values are 0.41, 0.75, >100 and >100 μ
M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G1
cell cycle arrest, inhibits proliferation and induces apoptosis in vitro
and in vivo
. Increases neuroplasticity during memory extinction.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.
Beckers et al.
Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.
Gr?ff et al.
Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma.
Kraker et al.
Mol.Cancer Ther., 2003;2:401