CI 994
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Description: Class I histone deacetylase inhibitor; orally active
Alternative Names: N-acetyldinaline
Chemical Name: 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Purity: ≥99%
Biological Activity
CI 994 is an orally active class I histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction. Also increases efficiency of hepatic differentiation of hPSCsTechnical Data
M.Wt:
269.3
Formula:
C15H15N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
112522-64-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.
Gr?ff et al.
Cell, 2014;156:261 -
Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma.
Kraker et al.
Mol.Cancer Ther., 2003;2:401 -
Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.
Beckers et al.
Int.J.Cancer, 2007;121:1138
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