Chemical Name: 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Biological ActivityCI 994 is an orally active class I histone deacetylase (HDAC) inhibitor (Ki values are 0.41, 0.75, >100 and >100 μM for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo. Increases neuroplasticity during memory extinction. Also increases efficiency of hepatic differentiation of hPSCs
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.
Gr?ff et al.
Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benamide] in HCT-8 colon carcinoma.
Kraker et al.
Mol.Cancer Ther., 2003;2:401
Distinct pharamacologcial properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group.
Beckers et al.
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