Catalog Number: 2709
Alternate Names: MK 0791
Chemical Name: (2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid sodium salt
Biological Activity
Dipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a Ki value of 0.11 μM. Inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.
Technical Data
  • M.Wt:
    380.43
  • Formula:
    C16H25N2NaO5S
  • Solubility:
    Soluble to 100 mM in water and to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    81129-83-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Inhibition of the mammalian β-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids.
    Graham et al.
    J.Med.Chem., 1987;30:1074
  2. A continuous fluorometric assay for leukotriene D4 hydrolase.
    White et al.
    Anal.Biochem., 1999;268:245
  3. Inhibition of brush border dipeptidase with cilastatin reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.
    Perez et al.
    Nephrol.Dial.Transplant., 2004;19:2445

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