Cilastatin sodium

   
Product Datasheet
Catalog Number:2709
Alternate Names:MK 0791
Chemical Name:(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid sodium salt
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Biological Activity
Dipeptidase inhibitor (LTDase, leukotriene D4 hydrolase, dehydropeptidase I) that displays a Ki value of 0.11 μM. Inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Nephroprotective; reduces toxic accumulation of cyclosporin A in kidney proximal tubule epithelial cells.
Technical Data
  • M.Wt:
    380.43
  • Formula:
    C16H25N2NaO5S
  • Solubility:
    Soluble to 100 mM in water and to 10 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at -20°C
  • CAS No:
    81129-83-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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