Chemical Name: Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate
Biological ActivityCINPA 1 is a potent CAR antagonist (IC50 = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.
Cherian et al.
Citation for CINPA 1
The citations listed below are publications that use Tocris products. Selected citations for CINPA 1 include:
1 Citation: Showing 1 - 1
Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.
Authors: Boussadia Et al.
Exp Neurol 2016;283:39
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