Potent CAR antagonist (IC50
= 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ
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All Tocris products are intended for laboratory research use only.
CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.
Cherian et al.