Catalog Number: 1695
Alternate Names: R 51619
Chemical Name: (±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
Biological Activity
5-HT4 receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT4 receptor-dependent and -independent mechanisms, leading to increased intestinal motility.
Technical Data
  • M.Wt:
    465.95
  • Formula:
    C23H29ClFN3O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    81098-60-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea-pig colon ascendens.
    Briejer et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1993;347:464
  2. Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig.
    Schuurkes et al.
    J.Pharmacol.Exp.Ther., 1985;234:775
  3. Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors.
    Taniyama et al.
    J.Pharmacol.Exp.Ther., 1991;258:1098
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Cisapride include:

1 Citations: Showing 1 - 1

  1. A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4).
    Authors: Padayatti Et al.
    Mol Cell Proteomics 2013;12:1259

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