Chemical Name: (±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
Biological ActivityCisapride is a 5-HT4 receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT4 receptor-dependent and -independent mechanisms, leading to increased intestinal motility.
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Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea-pig colon ascendens.
Briejer et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1993;347:464
Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors.
Taniyama et al.
Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig.
Schuurkes et al.
Citations for Cisapride
The citations listed below are publications that use Tocris products. Selected citations for Cisapride include:
4 Citations: Showing 1 - 4
A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4).
Authors: Padayatti Et al.
Mol Cell Proteomics 2013;12:1259
The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties.
Authors: Beattie Et al.
Front Pharmacol 2011;2:25
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925
Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes.
Authors: Xiang Et al.
J Neurophysiol 2005;93:1145
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