Catalog Number: 1709
Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Biological Activity
Benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
Technical Data
  • M.Wt:
    278.24
  • Formula:
    C13H9F3N4
  • Solubility:
    Soluble to 50 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    66548-69-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Benzodiazepine receptors: cellular and behavioral characteristics.
    Lippa et al.
    Pharmacol.Biochem.Behav., 1979;10:831
  2. Structure and pharmacology of γ-aminobutyric acidA receptor subtypes.
    Sieghart
    Pharmacol.Rev., 1995;47:181
  3. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors.
    Squires et al.
    Pharmacol.Biochem.Behav., 1979;10:825

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