CL 218872

Catalog # Availability Size / Price Qty
1709/10
CL 218872 | CAS No. 66548-69-4 | GABA-A Receptor Benzodiazepines
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Description: Benzodiazepine agonist

Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Technical Data

M.Wt:
278.24
Formula:
C13H9F3N4
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
66548-69-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Benzodiazepine receptors: cellular and behavioral characteristics.
    Lippa et al.
    Pharmacol.Biochem.Behav., 1979;10:831
  2. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors.
    Squires et al.
    Pharmacol.Biochem.Behav., 1979;10:825
  3. Structure and pharmacology of γ-aminobutyric acidA receptor subtypes.
    Sieghart
    Pharmacol.Rev., 1995;47:181

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Citation for CL 218872

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