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CL 218872

Catalog #: 1709
1 Citation Datasheet / COA / SDS

Discontinued Product

1709 has been discontinued.
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CL 218872 | CAS No. 66548-69-4 | GABA-A Receptor Benzodiazepines
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Description: Benzodiazepine agonist

Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Technical Data

M.Wt:
278.24
Formula:
C13H9F3N4
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
66548-69-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Benzodiazepine receptors: cellular and behavioral characteristics.
    Lippa et al.
    Pharmacol.Biochem.Behav., 1979;10:831
  2. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors.
    Squires et al.
    Pharmacol.Biochem.Behav., 1979;10:825
  3. Structure and pharmacology of γ-aminobutyric acidA receptor subtypes.
    Sieghart
    Pharmacol.Rev., 1995;47:181

Product Datasheets

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Citation for CL 218872

The citations listed below are publications that use Tocris products. Selected citations for CL 218872 include:

1 Citation: Showing 1 - 1

  1. Contribution of the α5 GABAA receptor to the discriminative stimulus effects of PROP in rat.
    Authors: Wang Et al.
    Neuroreport  2018;29:347

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