Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Biological ActivityCL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Benzodiazepine receptors: cellular and behavioral characteristics.
Lippa et al.
Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors.
Squires et al.
Structure and pharmacology of γ-aminobutyric acidA receptor subtypes.
Citation for CL 218872
The citations listed below are publications that use Tocris products. Selected citations for CL 218872 include:
1 Citation: Showing 1 - 1
Contribution of the α5 GABAA receptor to the discriminative stimulus effects of PROP in rat.
Authors: Wang Et al.
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