Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine
Biological ActivityBenzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Benzodiazepine receptors: cellular and behavioral characteristics.
Lippa et al.
Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors.
Squires et al.
Structure and pharmacology of γ-aminobutyric acidA receptor subtypes.
Citation for CL 218872
The citations listed below are publications that use Tocris products. Selected citations for CL 218872 include:
1 Citation: Showing 1 - 1
Contribution of the α5 GABAA receptor to the discriminative stimulus effects of PROP in rat.
Authors: Wang Et al.
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