CL 218872

Key Product Details

Product Description

CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABA_A receptors (K_i values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Product Specifications for CL 218872

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CL 218872

The following data is based on the product molecular weight 278.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	7.19 mL	35.94 mL	71.88 mL
2.5 mM	1.44 mL	7.19 mL	14.38 mL
5 mM	0.72 mL	3.59 mL	7.19 mL
25 mM	0.14 mL	0.72 mL	1.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Sieghart Structure and pharmacology of γ-aminobutyric acid_A receptor subtypes. Pharmacol.Rev. 1995 PMID: 7568326
• Squires Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. Pharmacol.Biochem.Behav. 1979 PMID: 40257
• Lippa Benzodiazepine receptors: cellular and behavioral characteristics. Pharmacol.Biochem.Behav. 1979 PMID: 40258

Product Documents for CL 218872