CL 218872

Discontinued Product

1709 has been discontinued.
View all GABA-A Receptor Benzodiazepines products.
CL 218872 | CAS No. 66548-69-4 | GABA-A Receptor Benzodiazepines
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Description: Benzodiazepine agonist

Chemical Name: 3-Methyl-6-[-3-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.

Technical Data

Soluble to 50 mM in DMSO and to 25 mM in ethanol
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Benzodiazepine receptors: cellular and behavioral characteristics.
    Lippa et al.
    Pharmacol.Biochem.Behav., 1979;10:831
  2. Some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors.
    Squires et al.
    Pharmacol.Biochem.Behav., 1979;10:825
  3. Structure and pharmacology of γ-aminobutyric acidA receptor subtypes.
    Pharmacol.Rev., 1995;47:181

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Citation for CL 218872

The citations listed below are publications that use Tocris products. Selected citations for CL 218872 include:

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