Potent and highly selective β3
-adrenoceptor agonist (EC50
= 3 nM); > 10000-fold selective over β1
receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo
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Disodium(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and a
Bloom et al.
Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific β3-adrenoceptor agonist, in yellow KK mice.
Yoshida et al.
Life Sci., 1994;54:491
Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental bladder hyperflexia and detrusor instability in the rat.
Woods et al.
The citations listed below are publications that use Tocris products. Selected citations for CL 316243 disodium salt include:
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