Catalog Number: 1499
Chemical Name: 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
Biological Activity
Potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM); > 10000-fold selective over β1 and β2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo.
Technical Data
  • M.Wt:
    465.8
  • Formula:
    C20H18ClNNa2O7
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    151126-84-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Disodium(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and a
    Bloom et al.
    J.Med.Chem., 1992;35:3081
  2. Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific β3-adrenoceptor agonist, in yellow KK mice.
    Yoshida et al.
    Life Sci., 1994;54:491
  3. Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental bladder hyperflexia and detrusor instability in the rat.
    Woods et al.
    J.Urol., 2001;166:1142
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CL 316243 disodium salt include:

11 Citations: Showing 1 - 10
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  1. An additive effect of promoting thermogenic gene expression in mice adipose-derived stromal vascular cells by combination of rosiglitazone and CL316,243
    Authors: Li
    Int J Mol Sci 2017;18(5):E1002
  2. Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity.
    Authors: Chen Et al.
    Bladder (San Franc) 2016;7:11420
  3. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.
    Authors: Berbée Et al.
    J Neurosci 2015;6:6356
  4. Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation.
    Authors: Kashyap Et al.
    Cell Rep 2015;2
  5. Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans.
    Authors: Patsouris Et al.
    Nat Commun 2015;13:1538
  6. Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia.
    Authors: Nagai Et al.
    PLoS One 2015;10:e0131923
  7. Browning of white adipose tissue uncouples glucose uptake from insulin signaling.
    Authors: Mössenböck Et al.
    PLoS One 2014;9:e110428
  8. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
    Authors: Suárez Et al.
    Dis Model Mech 2014;7:129
  9. MicroRNA-378 controls classical brown fat expansion to counteract obesity.
    Authors: Pan Et al.
    Nat Commun 2014;5:4725
  10. Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
    Authors: Rieg Et al.
    PLoS One 2012;6:e29698
  11. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance.
    Authors: Enriori Et al.
    Am J Pathol 2011;31:12189
Expand to show all 11 Citations

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