CL 316243 disodium salt

  ( 13 citations )    
Product Datasheet
Catalog Number:1499
Chemical Name:5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
Product Details
Citations (13)
Supplemental Products
Reviews
Biological Activity
Potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM); > 10000-fold selective over β1 and β2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo.
Technical Data
  • M.Wt:
    465.8
  • Formula:
    C20H18ClNNa2O7
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    151126-84-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for CL 316243 disodium salt include:

13 Citations: Showing 1 - 10
Filter your results:

  1. Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation.
    Authors: Huang Et al.
    Nat Commun  2017;8:68
  2. An additive effect of promoting thermogenic gene expression in mice adipose-derived stromal vascular cells by combination of rosiglitazone and CL316,243
    Authors: Li
    Int J Mol Sci  2017;18(5):E1002
  3. Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity.
    Authors: Chen Et al.
    Bladder (San Franc)  2016;7:11420
  4. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.
    Authors: Berbée Et al.
    J Neurosci  2015;6:6356
  5. Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation.
    Authors: Kashyap Et al.
    Cell Rep  2015;2
  6. Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans.
    Authors: Patsouris Et al.
    Nat Commun  2015;13:1538
  7. Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia.
    Authors: Nagai Et al.
    PLoS One  2015;10:e0131923
  8. Browning of white adipose tissue uncouples glucose uptake from insulin signaling.
    Authors: Mössenböck Et al.
    PLoS One  2014;9:e110428
  9. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
    Authors: Suárez Et al.
    Dis Model Mech  2014;7:129
  10. MicroRNA-378 controls classical brown fat expansion to counteract obesity.
    Authors: Pan Et al.
    Nat Commun  2014;5:4725
  11. Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
    Authors: Rieg Et al.
    PLoS One  2012;6:e29698
  12. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance.
    Authors: Enriori Et al.
    Am J Pathol  2011;31:12189
  13. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
    Authors: Nackley Et al.
    Pain  2007;128:199
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used CL 316243 disodium salt?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee