CL 316243 disodium salt

  ( 13 citations )    
Product Datasheet
Catalog Number:1499
Chemical Name:5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
Product Details
Citations (13)
Supplemental Products
Biological Activity
Potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM); > 10000-fold selective over β1 and β2 receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for CL 316243 disodium salt include:

13 Citations: Showing 1 - 10
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  1. Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation.
    Authors: Huang Et al.
    Nat Commun  2017;8:68
  2. An additive effect of promoting thermogenic gene expression in mice adipose-derived stromal vascular cells by combination of rosiglitazone and CL316,243
    Authors: Li
    Int J Mol Sci  2017;18(5):E1002
  3. Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity.
    Authors: Chen Et al.
    Bladder (San Franc)  2016;7:11420
  4. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development.
    Authors: Berbée Et al.
    J Neurosci  2015;6:6356
  5. Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation.
    Authors: Kashyap Et al.
    Cell Rep  2015;2
  6. Burn Induces Browning of the Subcutaneous White Adipose Tissue in Mice and Humans.
    Authors: Patsouris Et al.
    Nat Commun  2015;13:1538
  7. Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia.
    Authors: Nagai Et al.
    PLoS One  2015;10:e0131923
  8. Browning of white adipose tissue uncouples glucose uptake from insulin signaling.
    Authors: Mössenböck Et al.
    PLoS One  2014;9:e110428
  9. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
    Authors: Suárez Et al.
    Dis Model Mech  2014;7:129
  10. MicroRNA-378 controls classical brown fat expansion to counteract obesity.
    Authors: Pan Et al.
    Nat Commun  2014;5:4725
  11. Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
    Authors: Rieg Et al.
    PLoS One  2012;6:e29698
  12. Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance.
    Authors: Enriori Et al.
    Am J Pathol  2011;31:12189
  13. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
    Authors: Nackley Et al.
    Pain  2007;128:199
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