CL 316243 disodium salt

Key Product Details

Product Description

CL 316243 disodium salt is a potent and highly selective β₃-adrenoceptor agonist (EC₅₀ = 3 nM); > 10000-fold selective over β₁ and β₂ receptors. Increases brown adipose tissue thermogenesis and metabolic rate, and decreases blood insulin and glucose levels following oral administration in vivo.

Product Specifications for CL 316243 disodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for CL 316243 disodium salt

The following data is based on the product molecular weight 465.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.73 mL	21.47 mL
5 mM	0.43 mL	2.15 mL	4.29 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 68 publications citing the usage of this product.

• Woods Efficacy of the β3-adrenergic receptor agonist CL-316243 on experimental bladder hyperflexia and detrusor instability in the rat. J.Urol. 2001 PMID: 11490313
• Yoshida Anti-obesity and anti-diabetic effects of CL 316,243, a highly specific β₃-adrenoceptor agonist, in yellow KK mice. Life Sci. 1994 PMID: 8309351
• Bloom Disodium(R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and a J.Med.Chem. 1992 PMID: 1354264

Product Documents for CL 316243 disodium salt