Chemical Name: 14β-(p-Chlorocinnamoylamino)-7,8-dihydro-N-cyclopropylmethylmorphinone mesylate
Biological ActivityClocinnamox mesylate is a systemically active, irreversible μ-opioid receptor antagonist (apparent Ki values are 0.7, 1.9 and 5.7 nM for mouse μ, δ and κ receptors respectively).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice.
Burke et al.
Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitro and ex vivo binding and behavioural assays.
Zernig et al.
Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, β-funaltrexamine, and β-chlornaltrexamine.
Broadbear et al.
Very long-acting narcotic antagonists. The 14β-p-substituted cinnamoylaminomorphinones and their partial mu agonist codeinone relatives.
Aceto et al.
Citation for Clocinnamox mesylate
The citations listed below are publications that use Tocris products. Selected citations for Clocinnamox mesylate include:
1 Citation: Showing 1 - 1
The analgesic efficacy of fentanyl: relationship to tolerance and mu-opioid receptor regulation.
Authors: Sirohi Et al.
Pharmacol Biochem Behav 2008;91:115
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