Chemical Name: 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Biological ActivityClonidine hydrochloride is a prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Williams et al.
Isolation of a human cerebral imidazoline-specific binding protein.
Greney et al.
Mechanism of relaxant effect of clon. in isolated bovine tracheal smooth muscle.
Armitsu et al.
clon. binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla.
Ernsberger et al.
Dual effect of clon. on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1).
Silva et al.
Citations for Clonidine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Clonidine hydrochloride include:
9 Citations: Showing 1 - 9
Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors.
Authors: Harris Et al.
J Neurosci 2018;38:8922
Selective inhibition of DA-β-hydroxylase enhances DA release from noradrenergic terminals in the medial prefrontal cortex.
Authors: Devoto Et al.
Mol Pain 2015;5:e00393
Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons.
Authors: Yuen Et al.
J Biol Chem 2014;289:25177
Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit.
Authors: Cinelli Et al.
Physiol Rep 2013;1:e00122
Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
Authors: Asiedu Et al.
J Pain 2012;13:546
Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents.
Authors: Okun Et al.
Purinergic Signal 2011;7:4
Ongoing pain in the MIA model of osteoarthritis.
Authors: Liu Et al.
Neurosci Lett 2011;493:72
Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation.
Authors: Kim Et al.
Brain Res 2011;1384:110
Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with mor.
Authors: Garzón Et al.
Mol Pain 2009;5:11
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Behavioral pharmacology. Systemic blockade of alpha2- noradrenergic receptors. Dissolved in water at doses of 0.01-1.0 mg/mL and injected systemically in rats. Has sedative effects on motor movement.