Clonidine hydrochloride

Tocris Bioscience | Catalog # 0690

α2 agonist. Also I1 ligand
Tocris Bioscience

Key Product Details

Description

α2 agonist. Also I1 ligand
View all Adrenergic alpha-2 Receptor Agonists »

Product Description

Clonidine hydrochloride is a prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Product Specifications for Clonidine hydrochloride

Molecular Weight

266.56

Formula

C9H9Cl2N3.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride

CAS Number

4205-91-8

PubChem ID

20179

InChI Key

ZNIFSRGNXRYGHF-UHFFFAOYSA-N

SMILES

Cl[H].ClC1=CC=CC(Cl)=C1\N=C1/NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.66 100
DMSO 13.33 50

Preparing Stock Solutions for Clonidine hydrochloride

The following data is based on the product molecular weight 266.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.76 mL 37.52 mL
5 mM 0.75 mL 3.75 mL 7.50 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 38 publications citing the usage of this product.

Product Documents for Clonidine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Clonidine hydrochloride

For research use only

Citations for Clonidine hydrochloride

Customer Reviews for Clonidine hydrochloride (1)

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  • Behavioral pharmacology studies in rodents
    Name: Anonymous
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/04/2018
    High doses (great than 1 mg/kg) results in self-injurious behavior in rats.
    Behavioral pharmacology. Systemic blockade of alpha2- noradrenergic receptors. Dissolved in water at doses of 0.01-1.0 mg/mL and injected systemically in rats. Has sedative effects on motor movement.

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