Catalog Number: 0690
Chemical Name: 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Biological Activity
Prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
    Williams et al.
    Nat.Chem.Biol., 2008;4:295
  3. Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle.
    Armitsu et al.
    J.Pharmacol.Exp.Ther., 1998;286:681
  4. Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla.
    Ernsberger et al.
    Eur.J.Pharmacol., 1987;134:1
  5. Isolation of a human cerebral imidazoline-specific binding protein.
    Greney et al.
    Eur.J.Pharmacol., 1994;265:R1
  6. Dual effect of clonidine on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1).
    Silva et al.
    J.Pharmacol.Exp.ther., 1996;277:872
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