Clonidine hydrochloride

  ( 7 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0690
Chemical Name:2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity
Prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.
Technical Data
  • M.Wt:
    266.56
  • Formula:
    C9H9Cl2N3.HCl
  • Solubility:
    Soluble to 100 mM in water and to 75 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    4205-91-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Clonidine hydrochloride include:

7 Citations: Showing 1 - 7
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  1. Selective inhibition of dopamine-β-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex.
    Authors: Devoto Et al.
    Mol Pain  2015;5:e00393
  2. Suppression of the cough reflex by α 2-adrenergic receptor agonists in the rabbit.
    Authors: Cinelli Et al.
    Physiol Rep  2013;1:e00122
  3. Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
    Authors: Asiedu Et al.
    J Pain  2012;13:546
  4. Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents.
    Authors: Okun Et al.
    Purinergic Signal  2011;7:4
  5. Ongoing pain in the MIA model of osteoarthritis.
    Authors: Liu Et al.
    Neurosci Lett  2011;493:72
  6. Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation.
    Authors: Kim Et al.
    Brain Res  2011;1384:110
  7. Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine.
    Authors: Garzón Et al.
    Mol Pain  2009;5:11

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Average Rating: 5 (Based on 1 review)

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Summary

Species Rat

Other Experimental Details

Other Experimental Details High doses (great than 1 mg/kg) results in self-injurious behavior in rats.

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