CometAssay HT Sample Kit
CometAssay HT Sample Kit Summary
Key Benefits
• Specially treated slides to promote agarose adherence
• Ready to use low melt agarose (LMAgarose) in convenient size
• Lysis Solution suitable for either alkaline or neutral comet assay
• Optimized electrophoresis conditions
Product Specifications
- Applicable for the analysis of either single- or double-strand DNA breaks
- Study cellular responses to DNA damage
- Screen for inhibitors of DNA repair
- Test chemicals for toxicity
- Screen for environmental mutagens
Kit Contents
• CometAssay Lysis Solution
• CometAssay LMAgarose
• 200 mM EDTA, pH 10
• CometSlides (20 Well, 2 Slides)
Specifications
Limitations
For research use only. Not for diagnositic use.
Product Datasheets
Citations for CometAssay HT Sample Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells
Authors: B Zhai, Y Li, SS Kotapalli, J Bacha, D Brown, A Steinø, M Daugaard
Cell Death Dis, 2020;11(7):577. 2020
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Genome-wide CRISPR-Cas9 screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition
Authors: J Liang, H Zhao, BH Diplas, S Liu, J Liu, D Wang, Y Lu, Q Zhu, J Wu, W Wang, H Yan, YX Zeng, X Wang, Y Jiao
Cancer Res., 2019;0(0):. 2019
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The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination
Authors: J Martino, GJ Brunette, J Barroso-Go, TN Moiseeva, CM Smith, CJ Bakkenist, RJ O'Sullivan, KA Bernstein
Nucleic Acids Res., 2019;47(19):10151-10165. 2019
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Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.
Authors: Gatti L, Cossa G, Tinelli S, Carenini N, Arrighetti N, Pennati M, Cominetti D, de Cesare M, Zunino F, Zaffaroni N, Perego P
J Pharmacol Exp Ther, 2014;348(3):360-71. 2014
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Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed.
Authors: Weeks L, Fu P, Gerson S
Mol Cancer Ther, 0;12(10):2248-60. 0
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Intracellular deoxyribonucleotide pool imbalance and DNA damage in cells treated with hydroxyurea, an inhibitor of ribonucleotide reductase.
Authors: Osterman Golkar S, Czene S, Gokarakonda A, Haghdoost S
Mutagenesis, 0;28(6):653-60. 0
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CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma.
Authors: Subramanian C, Hada M, Opipari A, Castle V, Kwok R
Mol Cancer Res, 0;11(2):173-81. 0
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Potential new mechanisms of placental damage in celiac disease: anti-transglutaminase antibodies impair human endometrial angiogenesis.
Authors: Di Simone N, De Spirito M, Di Nicuolo F, Tersigni C, Castellani R, Silano M, Maulucci G, Papi M, Marana R, Scambia G, Gasbarrini A
Biol Reprod, 0;89(4):88. 0
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Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage.
Authors: Lee H, Yoon C, Schmidt B, Park D, Zhang A, Erkizan H, Toretsky J, Kirsch D, Yoon S
Mol Cancer Ther, 0;12(11):2591-600. 0
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Targeting aberrant DNA double-strand break repair in triple-negative breast cancer with alpha-particle emitter radiolabeled anti-EGFR antibody.
Authors: Song H, Hedayati M, Hobbs R, Shao C, Bruchertseifer F, Morgenstern A, Deweese T, Sgouros G
Mol Cancer Ther, 0;12(10):2043-54. 0
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EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.
Authors: Pfaffle H, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes C, Sequist L, Zou L, Willers H
Cancer Res, 0;73(20):6254-63. 0
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Radioprotective properties of tocopherol succinate against ionizing radiation in mice.
Authors: Singh V, Singh P, Wise S, Posarac A, Fatanmi O
J Radiat Res, 0;54(2):210-20. 0
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A hormone-DNA repair circuit governs the response to genotoxic insult.
Authors: Goodwin J, Schiewer M, Dean J, Schrecengost R, de Leeuw R, Han S, Ma T, Den R, Dicker A, Feng F, Knudsen K
Cancer Discov, 0;3(11):1254-71. 0
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Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
Authors: Proia D, Zhang C, Sequeira M, Jimenez J, He S, Spector N, Shapiro G, Tolaney S, Nagai M, Acquaviva J, Smith D, Sang J, Bates R, El-Hariry I
Clin Cancer Res, 0;20(2):413-24. 0
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Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
Authors: Yang Y, Durando M, Smith-Roe S, Sproul C, Greenwalt A, Kaufmann W, Oh S, Hendrickson E, Vaziri C
Nucleic Acids Res, 0;41(4):2296-312. 0
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Thirdhand smoke causes DNA damage in human cells.
Authors: Hang B, Sarker A, Havel C, Saha S, Hazra T, Schick S, Jacob P, Rehan V, Chenna A, Sharan D, Sleiman M, Destaillats H, Gundel L
Mutagenesis, 0;28(4):381-91. 0
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Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle.
Authors: Dimitrov S, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston D
Genes Dev, 0;27(20):2274-91. 0
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Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.
Authors: Trinh B, Ko S, Barengo N, Lin S, Naora H
Cancer Res, 0;73(2):1000-10. 0
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Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.
Authors: Kim S, Jo S, Lee H, Kim T, Kim I, Yim J, Chung H
Anticancer Res, 0;33(12):5445-51. 0
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LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis.
Authors: Lehle S, Hildebrand D, Merz B, Malak P, Becker M, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O
Nucleic Acids Res, 0;42(6):e41. 0
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Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.
Authors: Sayers C, Papandreou I, Guttmann D, Maas N, Diehl J, Witze E, Koong A, Koumenis C
Mol Pharmacol, 0;83(3):594-604. 0
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hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
Authors: Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J
Mol Cell Biol, 0;33(24):4960-70. 0
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