CometAssay HT Sample Kit

Discontinued Product

4252-040-K has been discontinued.
View all CometAssays products.
Product Details
Citations (27)
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CometAssay HT Sample Kit Summary

Includes two specially treated 20-well CometSlides and sufficient reagents for 40 test samples.
 

Key Benefits

• Specially treated slides to promote agarose adherence
• Ready to use low melt agarose (LMAgarose) in convenient size
• Lysis Solution suitable for either alkaline or neutral comet assay
• Optimized electrophoresis conditions

Product Specifications

  • Applicable for the analysis of either single- or double-strand DNA breaks
  • Study cellular responses to DNA damage
  • Screen for inhibitors of DNA repair
  • Test chemicals for toxicity
  • Screen for environmental mutagens

Kit Contents

• CometAssay Lysis Solution
• CometAssay LMAgarose
• 200 mM EDTA, pH 10
• CometSlides (20 Well, 2 Slides)

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended on the label.
Storage
Store the unopened product at room temperature. Do not use past expiration date.
Species
N/A

Limitations

For research use only. Not for diagnostic use.

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Citations for CometAssay HT Sample Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

27 Citations: Showing 1 - 10
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  1. CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
    Authors: B Lan, S Zeng, S Zhang, X Ren, Y Xing, I Kutschick, S Pfeffer, B Frey, N Britzen-La, R Grützmann, N Cordes, C Pilarsky
    Cancers, 2022;14(2):.  2022
  2. SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome
    Authors: F Banfi, A Rubio, M Zaghi, L Massimino, G Fagnocchi, E Bellini, M Luoni, C Cancellier, A Bagliani, C Di Resta, C Maffezzini, A Ianielli, M Ferrari, R Piazza, L Mologni, V Broccoli, A Sessa
    Nature Communications, 2021;12(1):4050.  2021
  3. Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing
    Authors: J Li, F Liu, Y Lv, K Sun, Y Zhao, J Reilly, Y Zhang, J Tu, S Yu, X Liu, Y Qin, Y Huang, P Gao, D Jia, X Chen, Y Han, X Shu, D Luo, Z Tang, M Liu
    Nucleic Acids Research, 2021;0(0):.  2021
  4. Occupational exposure and markers of genetic damage, systemic inflammation and lung function: a Danish cross-sectional study among air force personnel
    Authors: MHG Andersen, AT Saber, M Frederikse, PA Clausen, CS Sejbaek, CH Hemmingsen, NE Ebbehøj, J Catalán, K Aimonen, J Koivisto, S Loft, P Møller, U Vogel
    Scientific Reports, 2021;11(1):17998.  2021
  5. Checkpoint kinase?1 inhibition and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologous recombination DNA damage repair
    Authors: Z Fan, H Luo, J Zhou, F Wang, W Zhang, J Wang, S Li, Q Lai, Y Xu, G Wang, A Liang, J Xu
    Oncol. Rep., 2020;44(5):2152-2164.  2020
  6. Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells
    Authors: B Zhai, Y Li, SS Kotapalli, J Bacha, D Brown, A Steinø, M Daugaard
    Cell Death Dis, 2020;11(7):577.  2020
  7. Genome-wide CRISPR-Cas9 screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition
    Authors: J Liang, H Zhao, BH Diplas, S Liu, J Liu, D Wang, Y Lu, Q Zhu, J Wu, W Wang, H Yan, YX Zeng, X Wang, Y Jiao
    Cancer Res., 2019;0(0):.  2019
  8. The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination
    Authors: J Martino, GJ Brunette, J Barroso-Go, TN Moiseeva, CM Smith, CJ Bakkenist, RJ O'Sullivan, KA Bernstein
    Nucleic Acids Res., 2019;47(19):10151-10165.  2019
  9. Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment.
    Authors: Gatti L, Cossa G, Tinelli S, Carenini N, Arrighetti N, Pennati M, Cominetti D, de Cesare M, Zunino F, Zaffaroni N, Perego P
    J Pharmacol Exp Ther, 2014;348(3):360-71.  2014
  10. Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage.
    Authors: Lee H, Yoon C, Schmidt B, Park D, Zhang A, Erkizan H, Toretsky J, Kirsch D, Yoon S
    Mol Cancer Ther, 0;12(11):2591-600.  0
  11. Intracellular deoxyribonucleotide pool imbalance and DNA damage in cells treated with hydroxyurea, an inhibitor of ribonucleotide reductase.
    Authors: Osterman Golkar S, Czene S, Gokarakonda A, Haghdoost S
    Mutagenesis, 0;28(6):653-60.  0
  12. CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma.
    Authors: Subramanian C, Hada M, Opipari A, Castle V, Kwok R
    Mol Cancer Res, 0;11(2):173-81.  0
  13. Potential new mechanisms of placental damage in celiac disease: anti-transglutaminase antibodies impair human endometrial angiogenesis.
    Authors: Di Simone N, De Spirito M, Di Nicuolo F, Tersigni C, Castellani R, Silano M, Maulucci G, Papi M, Marana R, Scambia G, Gasbarrini A
    Biol Reprod, 0;89(4):88.  0
  14. Radioprotective properties of tocopherol succinate against ionizing radiation in mice.
    Authors: Singh V, Singh P, Wise S, Posarac A, Fatanmi O
    J Radiat Res, 0;54(2):210-20.  0
  15. Targeting aberrant DNA double-strand break repair in triple-negative breast cancer with alpha-particle emitter radiolabeled anti-EGFR antibody.
    Authors: Song H, Hedayati M, Hobbs R, Shao C, Bruchertseifer F, Morgenstern A, Deweese T, Sgouros G
    Mol Cancer Ther, 0;12(10):2043-54.  0
  16. A hormone-DNA repair circuit governs the response to genotoxic insult.
    Authors: Goodwin J, Schiewer M, Dean J, Schrecengost R, de Leeuw R, Han S, Ma T, Den R, Dicker A, Feng F, Knudsen K
    Cancer Discov, 0;3(11):1254-71.  0
  17. Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed.
    Authors: Weeks L, Fu P, Gerson S
    Mol Cancer Ther, 0;12(10):2248-60.  0
  18. hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
    Authors: Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J
    Mol Cell Biol, 0;33(24):4960-70.  0
  19. Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
    Authors: Proia D, Zhang C, Sequeira M, Jimenez J, He S, Spector N, Shapiro G, Tolaney S, Nagai M, Acquaviva J, Smith D, Sang J, Bates R, El-Hariry I
    Clin Cancer Res, 0;20(2):413-24.  0
  20. Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage.
    Authors: Yang Y, Durando M, Smith-Roe S, Sproul C, Greenwalt A, Kaufmann W, Oh S, Hendrickson E, Vaziri C
    Nucleic Acids Res, 0;41(4):2296-312.  0
  21. Thirdhand smoke causes DNA damage in human cells.
    Authors: Hang B, Sarker A, Havel C, Saha S, Hazra T, Schick S, Jacob P, Rehan V, Chenna A, Sharan D, Sleiman M, Destaillats H, Gundel L
    Mutagenesis, 0;28(4):381-91.  0
  22. Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle.
    Authors: Dimitrov S, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston D
    Genes Dev, 0;27(20):2274-91.  0
  23. Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.
    Authors: Trinh B, Ko S, Barengo N, Lin S, Naora H
    Cancer Res, 0;73(2):1000-10.  0
  24. Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.
    Authors: Kim S, Jo S, Lee H, Kim T, Kim I, Yim J, Chung H
    Anticancer Res, 0;33(12):5445-51.  0
  25. LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis.
    Authors: Lehle S, Hildebrand D, Merz B, Malak P, Becker M, Schmezer P, Essmann F, Schulze-Osthoff K, Rothfuss O
    Nucleic Acids Res, 0;42(6):e41.  0
  26. Identification and characterization of a potent activator of p53-independent cellular senescence via a small-molecule screen for modifiers of the integrated stress response.
    Authors: Sayers C, Papandreou I, Guttmann D, Maas N, Diehl J, Witze E, Koong A, Koumenis C
    Mol Pharmacol, 0;83(3):594-604.  0
  27. EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity.
    Authors: Pfaffle H, Wang M, Gheorghiu L, Ferraiolo N, Greninger P, Borgmann K, Settleman J, Benes C, Sequist L, Zou L, Willers H
    Cancer Res, 0;73(20):6254-63.  0

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