Compound 401

Catalog # Availability Size / Price Qty
3271/10
Compound 401 | CAS No. 168425-64-7 | DNA-dependent Protein Kinase Inhibitors
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Description: Selective DNA-PK and mTOR inhibitor

Chemical Name: 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one

Purity: ≥99%

Product Details
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Biological Activity

Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC50 values are all > 100 μM). Induces apoptosis in vitro.

Technical Data

M.Wt:
281.31
Formula:
C16H15N3O2
Solubility:
Soluble to 10 mM in DMSO and to 5 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
168425-64-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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