Catalog Number: 3125
Biological Activity
Potent, non-competitive NMDA receptor antagonist (IC50 = 93 nM) that has been suggested to have NR2 subunit selectivity. Inhibits inward currents evoked by NMDA in central nervous system neurons (IC50 = 350 nM) and exhibits broad anticonvulsant and antiparkinsonian activity in vivo at doses devoid of behavioral toxicity.
Technical Data
  • M.Wt:
    3098.4
  • Formula:
    C127H201N35O49S3
  • Sequence:
    GEXXVAKMAAXLARXNIAKGCKVNCYP

    (Modifications: X = Gla, Disulfide bridge between 21 - 25)

  • Storage:
    Store at -20°C
  • CAS No:
    202925-60-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from University of Utah
Background References
  1. Structure-function relationships of the NMDA-receptor antagonist peptide, conantokin-R.
    Blandl et al.
    FEBS Lett., 2000;470:139
  2. The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors.
    Klein et al.
    J.Biol.Chem., 2001;276:26860
  3. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus.
    White et al.
    J.Pharmacol.Expr.Ther., 2000;292:425

Have you used Conantokin-R?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information