Potent and selective histamine H3
receptor antagonist (pKi
values are 7.61 and 8.27 at rat and human H3
receptors respectively). A steroidal alkaloid that displays in vitro
antiplasmodial activity (IC50
= 1.04 μ
M). Also has high affinity for α2C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
Zirihi et al.
The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
Zhao et al.
Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist.
Witte et al.