Chemical Name: N,N-Dimethyl-con-5-enin-3-amine
Biological ActivityPotent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
Zirihi et al.
The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
Zhao et al.
Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist.
Witte et al.
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