Discontinued Product

2409 has been discontinued.
View all Histamine H3 Receptor Antagonists products.
Histamine H3 Receptor Antagonists Small Molecule
1 Image
Description: Potent and selective H3 receptor antagonist

Chemical Name: N,N-Dimethyl-con-5-enin-3-amine

Product Details

Biological Activity

Potent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98).

Technical Data

Soluble to 50 mM in ethanol and to 50 mM in DMSO with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
    Zirihi et al.
    Bioorg.Med.Chem.Lett., 2005;15:2637
  2. The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
    Zhao et al.
    J.Med.Chem., 2008;51:5423
  3. Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist.
    Witte et al.
    Soc.Neurosci.Abstr., 2005;491:19

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Conessine

There are currently no reviews for this product. Be the first to review Conessine and earn rewards!

Have you used Conessine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.