Catalog Number: 3033
Alternate Names: CST-8
Biological Activity
Synthetic cortistatin analog that lacks the ability to bind somatostatin receptors but retains ghrelin receptor binding. Acts as a ghrelin receptor antagonist; counteracts the response of ghrelin on gastric acid secretion.
Technical Data
  • M.Wt:
    1009.25
  • Formula:
    C47H68N12O9S2
  • Sequence:
    PCFWKTCK

    (Modifications: Trp-4 = D-Trp, Disulfide bridge between 2 - 7, Lys-8 = C-terminal amide)

  • Solubility:
    Soluble to 2 mg/ml in 20% acetonitrile
  • Storage:
    Desiccate at -20°C
  • CAS No:
    485803-62-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes.
    Luque et al.
    J.Mol.Endocrinol., 2006;36:547
  2. Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat.
    Sibilia et al.
    J.Neuroendocrinol., 2006;18:122
  3. Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans.
    Prodam et al.
    Neuropeptides, 2008;42:89

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    3033 has been discontinued.

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