Cortistatin-8

Name: Cortistatin-8
Brand: Tocris Bioscience
SKU: 3033

Catalog #: 3033 Datasheet / COA / SDS

Discontinued Product

3033 has been discontinued.

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Description: Ghrelin receptor antagonist

Alternative Names: CST-8

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Product Details

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Biological Activity

Synthetic cortistatin analog that lacks the ability to bind somatostatin receptors but retains ghrelin receptor binding. Acts as a ghrelin receptor antagonist; counteracts the response of ghrelin on gastric acid secretion.

Technical Data

M.Wt:

1009.25

Formula:

C₄₇H₆₈N₁₂O₉S₂

Sequence:

PCFWKTCK

(Modifications: Trp-4 = D-Trp, Disulfide bridge between 2 - 7, Lys-8 = C-terminal amide)

Solubility:

Soluble to 2 mg/ml in 20% acetonitrile

Storage:

Desiccate at -20°C

CAS No:

485803-62-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on GH secretion in somatotropes.
Luque et al.
J.Mol.Endocrinol., 2006;36:547
Evidence for a role of the GHS-R_1a receptors in ghrelin inhibition of gastric acid secretion in the rat.
Sibilia et al.
J.Neuroendocrinol., 2006;18:122
Cortistatin-8, a synthetic cortistatin-derived ghrelin receptor ligand, does not modify the endocrine responses to acylated ghrelin or hexarelin in humans.
Prodam et al.
Neuropeptides, 2008;42:89

Product Datasheets

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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