Major tanshinone isolated from Salvia miltiorrhiza
that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50
= 4.6 μ
M). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC50
= 4.09 μ
M) and reduction in Aβ
Soluble to 10 mM in DMSO
Store at RT
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Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.
Shin et al.
Cancer Res., 2009;69:193
Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.
Kim et al.
Cryptotanshinone, a compound from Saliva miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro.
Zhang et al.