Cryptotanshinone

Catalog # Availability Size / Price Qty
3713/10
3713/50
Cryptotanshinone | CAS No. 35825-57-1 | STAT Inhibitors
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Description: STAT3 inhibitor. Also displays multiple other activities

Chemical Name: 1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione

Purity: ≥98%

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Biological Activity

Major tanshinone isolated from Salvia miltiorrhiza that exhibits multiple activities. Exhibits antitumor activity via inhibition STAT3 activity (IC50 = 4.6 μM). Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC50 = 4.09 μM) and reduction in Aβ peptide generation.

Technical Data

M.Wt:
296.36
Formula:
C19H20O3
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
35825-57-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.
    Kim et al.
    Mol.Pharmacol., 2007;72:62
  2. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.
    Shin et al.
    Cancer Res., 2009;69:193
  3. Cryptotanshinone, a compound from Saliva miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro.
    Zhang et al.
    Neurosci.Letts., 2009;452:90
  4. Cryptotanshinone, an acetylcholinesterase inhibitor from Salivia miltiorrhiza, ameliorates scopolamine-induced amnesia in morris water maze task.
    Wong et al.
    Planta Med., 2009;76:288

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