Cultrex 3D Culture BME Cell Invasion Assay, 96 well

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Citations (20)
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Cultrex 3D Culture BME Cell Invasion Assay, 96 well Summary

The Cultrex® 3D Culture BME Cell Invasion Assay utilizes a 3D Culture Qualified 96 Well Spheroid Formation Plate alongside a specialized Spheroid Formation ECM to drive aggregation and/or spheroid formation of cells. a completion of spheroid formation, the spheroid is embedded in an invasion matrix composed of basement membrane proteins. This matrix forms a hydrogel network on which invasive cells can travel. At this point, invasion modulating agents can be applied to the system to evaluate the impact on cell response. Cell invasion is visualized microscopically and can be quantitated through image analysis software.

Kit Contents

  • 3D Culture Qualified 96 Well Spheroid Formation Plate
  • 10X Spheroid Formation ECM
  • Invasion Matrix

Cultrex is a registered trademark of Trevigen, Inc.


Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
The unopened product  requires storage at both -20 to -70 °C and 2 - 8 °C.  Consult the product insert for specific storage temperatures.  Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Citations for Cultrex 3D Culture BME Cell Invasion Assay, 96 well

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

20 Citations: Showing 1 - 10
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  1. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis
    Authors: Q Lin, X Chen, F Meng, K Ogawa, M Li, R Song, S Zhang, Z Zhang, X Kong, Q Xu, F He, X Bai, B Sun, MC Hung, L Liu, J Wands, X Dong
    Mol. Cancer, 2019;18(1):156.  2019
  2. Bacopasides I and II Act in Synergy to Inhibit the Growth, Migration and Invasion of Breast Cancer Cell Lines
    Authors: HM Palethorpe, E Smith, Y Tomita, M Nakhjavani, AJ Yool, TJ Price, JP Young, AR Townsend, JE Hardingham
    Molecules, 2019;24(19):.  2019
  3. MicroRNA-214 targets PTK6 to inhibit tumorigenic potential and increase drug sensitivity of prostate cancer cells
    Authors: P Cagle, S Niture, A Srivastava, M Ramalinga, R Aqeel, L Rios-Colon, U Chimeh, S Suy, SP Collins, R Dahiya, D Kumar
    Sci Rep, 2019;9(1):9776.  2019
  4. Low-dose zoledronate for the treatment of bone metastasis secondary to prostate cancer
    Authors: E Akoury, P Ahangar, A Nour, J Lapointe, KP Guérard, L Haglund, DH Rosenzweig, MH Weber
    Cancer Cell Int., 2019;19(0):28.  2019
  5. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells
    Authors: A Kim, JY Ma
    Front Pharmacol, 2018;9(0):1455.  2018
  6. Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy
    Authors: H Xiao, HK Bid, X Chen, X Wu, J Wei, Y Bian, C Zhao, H Li, C Li, J Lin
    PLoS ONE, 2017;12(7):e0180297.  2017
  7. Estradiol promotes breast cancer cell migration via recruitment and activation of neutrophils
    Authors: G Vazquez Ro, A Abrahamsso, LD Jensen, C Dabrosin
    Cancer Immunol Res, 2017;0(0):.  2017
  8. Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix.
    Authors: Grossman M, Ben-Chetrit N, Zhuravlev A, Afik R, Bassat E, Solomonov I, Yarden Y, Sagi I
    Cancer Res, 2016;76(14):4249-58.  2016
  9. RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs
    Authors: Hiroaki Kajiho
    EMBO Rep, 2016;0(0):.  2016
  10. Musashi-2 (MSI2) supports TGF-beta signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis.
    Authors: Kudinov A, Deneka A, Nikonova A, Beck T, Ahn Y, Liu X, Martinez C, Schultz F, Reynolds S, Yang D, Cai K, Yaghmour K, Baker K, Egleston B, Nicolas E, Chikwem A, Andrianov G, Singh S, Borghaei H, Serebriiskii I, Gibbons D, Kurie J, Golemis E, Boumber Y
    Proc Natl Acad Sci U S A, 2016;113(25):6955-60.  2016
  11. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression.
    Authors: Esteve P, Zhang G, Ponnaluri V, Deepti K, Chin H, Dai N, Sagum C, Black K, Correa I, Bedford M, Cheng X, Pradhan S
    Nucleic Acids Res, 2015;0(0):.  2015
  12. The Epstein-Barr virus causes epithelial-mesenchymal transition in human corneal epithelial cells via Syk/src and Akt/Erk signaling pathways.
    Authors: Park G, Kim D, Kim Y, Kim S, Lee H, Yang J, Hur D
    Invest Ophthalmol Vis Sci, 2014;55(3):1770-9.  2014
  13. Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis.
    Authors: Baldassarre T, Watt K, Truesdell P, Meens J, Schneider M, Sengupta S, Craig A
    Mol Cancer Res, 0;13(6):1044-55.  0
  14. CXCL16 signaling mediated macrophage effects on tumor invasion of papillary thyroid carcinoma.
    Authors: Cho S, Kim Y, Sun H, Kim Y, Oh B, Yi K, Park D, Park Y
    Endocr Relat Cancer, 0;23(2):113-24.  0
  15. The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family.
    Authors: Busch B, Bley N, Muller S, Glass M, Misiak D, Lederer M, Vetter M, Strauss H, Thomssen C, Huttelmaier S
    Nucleic Acids Res, 0;44(8):3845-64.  0
  16. Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.
    Authors: Midde K, Aznar N, Laederich M, Ma G, Kunkel M, Newton A, Ghosh P
    Proc Natl Acad Sci U S A, 0;112(9):E937-46.  0
  17. Regulation of extracellular matrix degradation and metastatic spread by IQGAP1 through endothelin-1 receptor signaling in ovarian cancer.
    Authors: Chellini L, Caprara V, Spadaro F, Sestito R, Bagnato A, Rosano L
    Matrix Biol, 0;0(0):.  0
  18. The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer.
    Authors: Antony J, Tan T, Kelly Z, Low J, Choolani M, Recchi C, Gabra H, Thiery J, Huang R
    Sci Signal, 0;9(448):ra97.  0
  19. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.
    Authors: Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y, Yao J, Liang K, Wang S, Park P, Marks J, Zhou Y, Zhou J, Hung M, Liang H, Hu Z, Shen H, Hawke D, Han L, Zhou Y, Lin C, Yang L
    Nat Cell Biol, 0;19(3):238-251.  0
  20. The effect of bone morphogenetic protein-2 on osteosarcoma metastasis.
    Authors: Gill J, Connolly P, Roth M, Chung S, Zhang W, Piperdi S, Hoang B, Yang R, Guzik H, Morris J, Gorlick R, Geller D
    PLoS ONE, 0;12(3):e0173322.  0


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Cultrex 3D Culture BME Cell Invasion Assay, 96 well
By Anonymous on 04/02/2018

easy to use, excellent result