Cultrex Basement Membrane Extract, Type 3, Pathclear
Cultrex Basement Membrane Extract, Type 3, Pathclear Summary
Cultrex Basement Membrane Extract (BME), Type 3 is an extracellular matrix hydrogel that is qualified specifically for use in in vivo xenograft and tumorgraft models.Key Benefits
• Ideal for xenograft and tumorgraft models
• Designed to mimic the in vivo matrix microenvironment
• Quality controlled for performance consistency
Why Use Cultrex BME, Type 3?
Cultrex Basement Membrane Extract (BME), Type 3 is a soluble form of basement membrane purified from Engelbreth-Holm-Swarm (EHS) tumor. This extract provides a natural extracellular matrix hydrogel that polymerizes at 37°C to form a reconstituted basement membrane. Cultrex BME, Type 3 provides a proprietary formulation that is physiologically aligned with the in vivo solid tumor environment and is recommended for xenografts and other in vivo applications. This extracellular matrix hydrogel is designed to help cells to adapt to in vivo transplantation. It mimics the in vivo microenvironment, including low glucose and low pH, to improve take rate and growth of implanted cells for xenograft and tumorgraft models.
Basement membranes are continuous sheets of specialized extracellular matrix that form an interface between endothelial, epithelial, muscle, or neuronal cells and their adjacent stroma and that play an essential role in tissue organization by influencing cell adhesion, migration, proliferation, and differentiation. The major components of BME include laminin, collagen IV, entactin, and heparin sulfate proteoglycans.
Specifications
Gelling Assay - Cultrex BME, Type 3 gels in less than 30 minutes at 37 °C, and maintains the gelled form in culture medium for a minimum of 14 days at 37 °C.
Limitations
For research use only. Not for diagnostic use.
Product Datasheets
Citations for Cultrex Basement Membrane Extract, Type 3, Pathclear
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
Authors: R Yang, L Sun, CF Li, YH Wang, J Yao, H Li, M Yan, WC Chang, JM Hsu, JH Cha, JL Hsu, CW Chou, X Sun, Y Deng, CK Chou, D Yu, MC Hung
Nature Communications, 2021;12(1):832. 2021
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Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance
Authors: CM Yamazaki, A Yamaguchi, Y Anami, W Xiong, Y Otani, J Lee, NT Ueno, N Zhang, Z An, K Tsuchikama
Nature Communications, 2021;12(1):3528. 2021
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GRK2 suppresses lymphomagenesis by inhibiting the MALT1 proto-oncoprotein
Authors: J Cheng, LR Klei, NE Hubel, M Zhang, R Schairer, LM Maurer, HB Klei, H Kang, VJ Concel, PC Delekta, EV Dang, MA Mintz, M Baens, JG Cyster, N Parameswar, M Thome, PC Lucas, LM McAllister
J. Clin. Invest., 2020;130(2):1036-1051. 2020
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Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.
Authors: Doci C, Mikelis C, Lionakis M, Molinolo A, Gutkind J
Cancer Res, 0;75(14):2937-48. 0
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