Cultrex Basement Membrane Extract, Type 3, Pathclear

Cultrex Basement Membrane Extract, Type 3, Pathclear Summary

Key Benefits

• Ideal for xenograft and tumorgraft models
• Designed to mimic the in vivo matrix microenvironment
• Quality controlled for performance consistency

Why Use Cultrex BME, Type 3?

Cultrex Basement Membrane Extract (BME), Type 3 is a soluble form of basement membrane purified from Engelbreth-Holm-Swarm (EHS) tumor. This extract provides a natural extracellular matrix hydrogel that polymerizes at 37°C to form a reconstituted basement membrane. Cultrex BME, Type 3 provides a proprietary formulation that is physiologically aligned with the in vivo solid tumor environment and is recommended for xenografts and other in vivo applications. This extracellular matrix hydrogel is designed to help cells to adapt to in vivo transplantation. It mimics the in vivo microenvironment, including low glucose and low pH, to improve take rate and growth of implanted cells for xenograft and tumorgraft models.

Basement membranes are continuous sheets of specialized extracellular matrix that form an interface between endothelial, epithelial, muscle, or neuronal cells and their adjacent stroma and that play an essential role in tissue organization by influencing cell adhesion, migration, proliferation, and differentiation. The major components of BME include laminin, collagen IV, entactin, and heparin sulfate proteoglycans.

Specifications

Limitations

For research use only. Not for diagnositic use.

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