Cultrex Bovine Collagen I
Cultrex Bovine Collagen I Summary
• Qualified for general cell culture applications
• May be used as a hydrogel or thin coating for tissue culture vessels
• Material provided at a standard concentration of ~5 mg/mL
• Purified from fetal bovine extensor tendon
Why Use Cultrex Bovine Collagen I?
Cultrex Bovine Collagen I is purified from fetal bovine extensor tendons and is pepsin-treated to remove telopeptides. Collagen I is the major structural component of extracellular matrices (ECM) found in connective tissue and internal organs, but is most prevalent in the dermis, tendons, and bone. It is a 300 kDa molecule composed of two alpha1(I) chains and one alpha2(I) chain that spontaneously forms a triple helix scaffold at a neutral pH and 37°C. This phenomenon can be exploited to promote cell attachment, growth, differentiation, migration, and tissue morphogenesis during development. To provide the most standardized Collagen I, a special process is employed to provide material at a standard concentration of approximately 5 mg/mL.
For research use only. Not for diagnostic use.
Citations for Cultrex Bovine Collagen I
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
Authors: L Mao, YY Zhan, B Wu, Q Yu, L Xu, X Hong, L Zhong, P Mi, L Xiao, X Wang, H Cao, W Zhang, B Chen, J Xiang, K Mei, R Radhakrish, W Guo, T Hu
Nat Commun, 2020;11(1):117. 2020
Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA
Authors: K Wang, RZ Lin, X Hong, AH Ng, CN Lee, J Neumeyer, G Wang, X Wang, M Ma, WT Pu, GM Church, JM Melero-Mar
Sci Adv, 2020;6(30):eaba7606. 2020
A comprehensive library of human transcription factors for cell fate engineering
Authors: AHM Ng, P Khoshakhla, JE Rojo Arias, G Pasquini, K Wang, A Swiersy, SL Shipman, E Appleton, K Kiaee, RE Kohman, A Vernet, M Dysart, K Leeper, W Saylor, JY Huang, A Graveline, J Taipale, DE Hill, M Vidal, JM Melero-Mar, V Busskamp, GM Church
Nature Biotechnology, 2020;0(0):. 2020
Overlay repair with a synthetic collagen scaffold improves the quality of healing in a rat rotator cuff repair model
Authors: M Zhu, ML Tay, K Callon, D Tuari, L Zhao, M Dray, J Zhang, N Dalbeth, J Munro, S Young, B Coleman, D Patel, J Cornish, D Musson
J Shoulder Elbow Surg, 2019;0(0):. 2019
BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival
Authors: EF Lee, TJ Harris, S Tran, M Evangelist, S Arulananda, T John, C Ramnac, C Hobbs, H Zhu, G Gunasingh, D Segal, A Behren, J Cebon, A Dobrovic, JM Mariadason, A Strasser, L Rohrbeck, NK Haass, MJ Herold, WD Fairlie
Cell Death Dis, 2019;10(5):342. 2019
Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System.
Authors: Waschbisch A, Schroder S, Schraudner D, Sammet L, Weksler B, Melms A, Pfeifenbring S, Stadelmann C, Schwab S, Linker R
J Immunol, 2016;196(4):1558-67. 2016
Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system.
Authors: Heller B, Ghidinelli M, Voelkl J, Einheber S, Smith R, Grund E, Morahan G, Chandler D, Kalaydjieva L, Giancotti F, King R, Fejes-Toth A, Fejes-Toth G, Feltri M, Lang F, Salzer J
J Cell Biol, 2014;204(7):1219-36. 2014
A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis.
Authors: Spivey KA, Chung I, Banyard J
Oncogene, 2012;31(18):2362-72. 2012
Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants.
Authors: Fujinaga H, Baker CD, Ryan SL, Markham NE, Seedorf GJ, Balasubramaniam V, Abman SH
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(6):L1160-9. 2009
Erlotinib resistance in lung cancer cells mediated by integrin beta1/Src/Akt-driven bypass signaling.
Authors: Kanda R, Kawahara A, Watari K, Murakami Y, Sonoda K, Maeda M, Fujita H, Kage M, Uramoto H, Costa C, Kuwano M, Ono M
Cancer Res, 0;73(20):6243-53. 0
Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling.
Authors: Lin R, Moreno-Luna R, Li D, Jaminet S, Greene A, Melero-Martin J
Proc Natl Acad Sci U S A, 0;111(28):10137-42. 0
t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes.
Authors: Niego B, Freeman R, Puschmann T, Turnley A, Medcalf R
Blood, 0;119(20):4752-61. 0
PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.
Authors: Roy N, Takeuchi K, Ruggeri J, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman M, Gao S, Halbrook C, Song Y, Ljungman M, Malik S, Wright C, Dawson D, Biankin A, Hebrok M, Crawford H
Genes Dev, 0;30(24):2669-2683. 0
Is Bovine Collagen I (Catalog # 3442-050-01) atelocollagen or telocollagen?
Bovine Collagen I (Catalog # 3442-050-01) is atelocollagen.
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