Cultrex Bovine Collagen I

Purified stromal extracellular matrix protein that can promte cell adhesion for cell and tissue cultures
Catalog # Availability Size / Price Qty
Product Details
Citations (13)

Cultrex Bovine Collagen I Summary

Cultrex Bovine Collagen I is a purified stromal extracellular matrix protein that can promtes cell adhesion for cell and tissue culture. It may also be used to supplement customized coatings, hydrogels, bioinks, or medium formulations for cell culture.

Key Benefits

• Qualified for general cell culture applications
• May be used as a hydrogel or thin coating for tissue culture vessels
• Material provided at a standard concentration of ~5 mg/mL
• Purified from fetal bovine extensor tendon

Why Use Cultrex Bovine Collagen I?

Cultrex Bovine Collagen I is purified from fetal bovine extensor tendons and is pepsin-treated to remove telopeptides. Collagen I is the major structural component of extracellular matrices (ECM) found in connective tissue and internal organs, but is most prevalent in the dermis, tendons, and bone. It is a 300 kDa molecule composed of two alpha1(I) chains and one alpha2(I) chain that spontaneously forms a triple helix scaffold at a neutral pH and 37°C. This phenomenon can be exploited to promote cell attachment, growth, differentiation, migration, and tissue morphogenesis during development. To provide the most standardized Collagen I, a special process is employed to provide material at a standard concentration of approximately 5 mg/mL.


Fetal Bovine Extensor Tendons
Protein Concentration
5 mg/mL
Endotoxin Level
≤ 20 EU/mL by Limulus Amoebocyte Lysate (LAL) assay
Sterility Testing
No bacterial or fungal growth detected following 14 days in culture
Testing Cell Culture
Supports cell attachment and spreading of HT1080 human fibrosarcoma cells.
Viral Testing
No mycoplasma contamination detected by PCR.
Product is stable for a minimum of 2 months if stored at 2-8 °C. Do Not Freeze.
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended on the product label.
Store the unopened product at 2 - 8 °C.


For research use only. Not for diagnostic use.

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Citations for Cultrex Bovine Collagen I

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

13 Citations: Showing 1 - 10
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  1. A comprehensive library of human transcription factors for cell fate engineering
    Authors: AHM Ng, P Khoshakhla, JE Rojo Arias, G Pasquini, K Wang, A Swiersy, SL Shipman, E Appleton, K Kiaee, RE Kohman, A Vernet, M Dysart, K Leeper, W Saylor, JY Huang, A Graveline, J Taipale, DE Hill, M Vidal, JM Melero-Mar, V Busskamp, GM Church
    Nature Biotechnology, 2020-11-30;0(0):.  2020-11-30
  2. Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA
    Authors: K Wang, RZ Lin, X Hong, AH Ng, CN Lee, J Neumeyer, G Wang, X Wang, M Ma, WT Pu, GM Church, JM Melero-Mar
    Sci Adv, 2020-07-24;6(30):eaba7606.  2020-07-24
  3. ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
    Authors: L Mao, YY Zhan, B Wu, Q Yu, L Xu, X Hong, L Zhong, P Mi, L Xiao, X Wang, H Cao, W Zhang, B Chen, J Xiang, K Mei, R Radhakrish, W Guo, T Hu
    Nat Commun, 2020-01-08;11(1):117.  2020-01-08
  4. BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival
    Authors: EF Lee, TJ Harris, S Tran, M Evangelist, S Arulananda, T John, C Ramnac, C Hobbs, H Zhu, G Gunasingh, D Segal, A Behren, J Cebon, A Dobrovic, JM Mariadason, A Strasser, L Rohrbeck, NK Haass, MJ Herold, WD Fairlie
    Cell Death Dis, 2019-04-24;10(5):342.  2019-04-24
  5. Overlay repair with a synthetic collagen scaffold improves the quality of healing in a rat rotator cuff repair model
    Authors: M Zhu, ML Tay, K Callon, D Tuari, L Zhao, M Dray, J Zhang, N Dalbeth, J Munro, S Young, B Coleman, D Patel, J Cornish, D Musson
    J Shoulder Elbow Surg, 2019-02-02;0(0):.  2019-02-02
  6. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.
    Authors: Roy N, Takeuchi K, Ruggeri J, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman M, Gao S, Halbrook C, Song Y, Ljungman M, Malik S, Wright C, Dawson D, Biankin A, Hebrok M, Crawford H
    Genes Dev, 2016-12-15;30(24):2669-2683.  2016-12-15
  7. Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System.
    Authors: Waschbisch A, Schroder S, Schraudner D, Sammet L, Weksler B, Melms A, Pfeifenbring S, Stadelmann C, Schwab S, Linker R
    J Immunol, 2016-01-08;196(4):1558-67.  2016-01-08
  8. Human endothelial colony-forming cells serve as trophic mediators for mesenchymal stem cell engraftment via paracrine signaling.
    Authors: Lin R, Moreno-Luna R, Li D, Jaminet S, Greene A, Melero-Martin J
    Proc Natl Acad Sci U S A, 2014-06-30;111(28):10137-42.  2014-06-30
  9. Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system.
    Authors: Heller B, Ghidinelli M, Voelkl J, Einheber S, Smith R, Grund E, Morahan G, Chandler D, Kalaydjieva L, Giancotti F, King R, Fejes-Toth A, Fejes-Toth G, Feltri M, Lang F, Salzer J
    J Cell Biol, 2014-03-31;204(7):1219-36.  2014-03-31
  10. Erlotinib resistance in lung cancer cells mediated by integrin beta1/Src/Akt-driven bypass signaling.
    Authors: Kanda R, Kawahara A, Watari K, Murakami Y, Sonoda K, Maeda M, Fujita H, Kage M, Uramoto H, Costa C, Kuwano M, Ono M
    Cancer Res, 2013-07-19;73(20):6243-53.  2013-07-19
  11. t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes.
    Authors: Niego B, Freeman R, Puschmann T, Turnley A, Medcalf R
    Blood, 2012-01-19;119(20):4752-61.  2012-01-19
  12. A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis.
    Authors: Spivey KA, Chung I, Banyard J
    Oncogene, 2011-10-03;31(18):2362-72.  2011-10-03
  13. Hyperoxia disrupts vascular endothelial growth factor-nitric oxide signaling and decreases growth of endothelial colony-forming cells from preterm infants.
    Authors: Fujinaga H, Baker CD, Ryan SL, Markham NE, Seedorf GJ, Balasubramaniam V, Abman SH
    Am. J. Physiol. Lung Cell Mol. Physiol., 2009-09-04;297(6):L1160-9.  2009-09-04


  1. Is Bovine Collagen I (Catalog # 3442-050-01) atelocollagen or telocollagen?

    • Bovine Collagen I (Catalog # 3442-050-01) is atelocollagen.

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