Cultrex HA-R-Spondin1-Fc 293T Cells

1 vial (1x10^6 cell/vial)
Catalog # Availability Size / Price Qty
Product Details

Cultrex HA-R-Spondin1-Fc 293T Cells Summary

Stably transfected 293T cells expressing murine R-Spondin 1 that have an N-terminal HA epitope tag and are fused to a C-terminal murine IgG2a Fc fragment.

Why Use Cultrex HA-R-Spondin1-Fc 293T Cells?

Roof plate-specific Spondin-1, (R-Spondin 1, RSPO1, or CRISTIN3), is a 27 kDa secreted activator protein that belongs to the R-Spondin family. R-Spondin positively regulates Wnt/beta-catenin signaling by acting as a ligand for Lgr4-6 receptors and as an inhibitor for ZNRF3. R-Spondin 1 induces proliferation of intestinal crypt epithelial cells, increases intestinal epithelial healing, and supports intestinal epithelial stem cell renewal. Cultrex HA-R-Spondin 1-Fc 293T Cells are stably transfected to express murine R-Spondin 1 that contains an N-terminal HA epitope tag and is fused to a C-terminal murine IgG2a Fc fragment.

Cultrex HA-R-Spondin 1-Fc 293T cell line can be used to produce either purified R-Spondin 1 or R-Spondin 1-conditioned media. The murine R-Spondin 1 protein produced from this cell line has been used extensively in organoid culture to maintain Lgr5+ stem cells. The Fc and HA tags can be used for protein purification or characterization.

Kit Contents

• 1 vial (1x10^6 cell/vial) of Cultrex HA-R-Spondin1-Fc 293T Cells


Immediately thaw for use or, for long term storage, place in vapor phase of liquid nitrogen.
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Store in liquid nitrogen for up to 12 months from the date of receipt.


For research use only. Not for diagnositic use.

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