Cultrex Mouse Laminin I, Pathclear
Cultrex Mouse Laminin I, Pathclear Summary
Cultrex Mouse Laminin I, Pathclear is a purified basement membrane protein that has been developed and qualified as a extracellular matrix coating solution for cell attachment to tissue culture vessels.Key Benefits
• Produced and qualified for use in cell culture
• Pathclear-tested to ensure a pathogen and virus-free material
• Source tissue is LDEV-free
Why Use Cultrex Mouse Laminin I?
Cultrex Mouse Laminin I, Pathclear is purified from Engelbreth-Holm-Swarm (EHS) tumor and is Pathclear-certified to be free of common pathogens. Laminin I is a major component of the basement membrane which is a continuous sheet of specialized extracellular matrix that forms an interface between endothelial, epithelial, muscle, or neuronal cells and their adjacent stroma and that plays an essential role in tissue organization by influencing cell adhesion, migration, proliferation, and differentiation.
Specifications
Limitations
For research use only. Not for diagnostic use.
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Citations for Cultrex Mouse Laminin I, Pathclear
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Single Cell Analysis of Reversibility of the Cell Death Program in Ethanol-Treated Neuronal PC12 Cells
Authors: W You, TTJM Berendscho, K Knoops, MAMJ van Zandvo, CAB Webers, CPM Reutelings, TGMF Gorgels
International Journal of Molecular Sciences, 2022;23(5):. 2022
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Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01
Authors: J Piao, S Zabierowsk, BN Dubose, EJ Hill, M Navare, N Claros, S Rosen, K Ramnarine, C Horn, C Fredrickso, K Wong, B Safford, S Kriks, A El Maarouf, U Rutishause, C Henchcliff, Y Wang, I Riviere, S Mann, V Bermudez, S Irion, L Studer, M Tomishima, V Tabar
Cell Stem Cell, 2021;28(2):217-229.e7. 2021
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Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function
Authors: P Schiappare, NL Pirman, K Mohler, PA Miranda-He, N Zarco, O Kilic, C Miller, SR Shah, S Rogulina, W Hungerford, L Abriola, D Hoyer, BE Turk, H Guerrero-C, FJ Isaacs, A Quiñones-H, A Levchenko, J Rinehart
Cell Reports, 2021;36(3):109416. 2021
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Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity
Authors: M Plataki, L Fan, E Sanchez, Z Huang, LK Torres, M Imamura, Y Zhu, DE Cohen, SM Cloonan, AM Choi
JCI Insight, 2019;5(0):. 2019
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Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons
Authors: RO Costa, H Martins, LF Martins, AW Cwetsch, M Mele, JR Pedro, D Tomé, NL Jeon, L Cancedda, SR Jaffrey, RD Almeida
Cell Rep, 2019;28(4):864-876.e6. 2019
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The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor
Authors: JM Aye, LL Stafman, AP Williams, EF Garner, JE Stewart, JC Anderson, S Mruthyunja, MG Waldrop, CD Goolsby, HR Markert, C Quinn, R Marayati, E Mroczek-Mu, CD Willey, KJ Yoon, KF Whelan, EA Beierle
Oncotarget, 2019;10(53):5534-5548. 2019
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Focal Adhesion Kinase Inhibition Contributes to Tumor Cell Survival and Motility in Neuroblastoma Patient-Derived Xenografts
Authors: LL Stafman, AP Williams, R Marayati, JM Aye, HR Markert, EF Garner, CH Quinn, SB Lallani, JE Stewart, KJ Yoon, K Whelan, EA Beierle
Sci Rep, 2019;9(1):13259. 2019
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A cell fitness selection model for neuronal survival during development
Authors: Y Wang, H Wu, P Fontanet, S Codeluppi, N Akkuratova, C Petitpré, Y Xue-Franzé, K Niederreit, A Sharma, F Da Silva, G Comai, G Agirman, D Palumberi, S Linnarsson, I Adameyko, A Moqrich, A Schedl, G La Manno, S Hadjab, F Lallemend
Nat Commun, 2019;10(1):4137. 2019
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Mechanisms of hyperexcitability in Alzheimer's disease hiPSC-derived neurons and cerebral organoids vs. isogenic control
Authors: S Ghatak, N Dolatabadi, D Trudler, X Zhang, Y Wu, M Mohata, R Ambasudhan, M Talantova, SA Lipton
Elife, 2019;8(0):. 2019
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Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics
Authors: A Ordureau, JA Paulo, W Zhang, T Ahfeldt, J Zhang, EF Cohn, Z Hou, JM Heo, LL Rubin, SS Sidhu, SP Gygi, JW Harper
Mol. Cell, 2018;70(2):211-227.e8. 2018
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Amacrine cell subtypes differ in their intrinsic neurite growth capacity.
Authors: Kunzevitzky N, Willeford K, Feuer W, Almeida M, Goldberg J
Invest Ophthalmol Vis Sci, 0;54(12):7603-13. 0
FAQs
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What is the recommended working concentration for Cultrex Laminin I?
The recommended working concentration for thin coating is 0.05-10 µg/cm2 . However, conditions must be optimized for each cell line or model. Cultrex Laminin I should be used at 6 mg/mL for 3-D culture applications.
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What is Laminin I?
Laminin I is a major component of extracellular matrix. Cultrex Laminin I is purified from murine EHS sarcoma. It is composed of α1β1γ1 chains with a total MW of 800,000 Da. Cultrex Laminin I increases cell adhesion, migration, growth, differentiation, neurite outgrowth, protease production, and malignancy. The response is dependent on cell type.
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Can Cultrex Mouse Laminin I be used on glass cover slips?
Coating glass cover slips with Cultrex Laminin I is quite common and has been published extensively.
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