Cultrex Spheroid Invasion Extracellular Matrix SummaryProvides a specialized extracellular matrix that is optimized to drive invasion of cells out of the preformed spheroids as a part of the Cultrex 3-D Culture Spheroid Cell Invasion Assay.
Why Use Cultrex Spheroid Invasion Extracellular Matrix?
The Cultrex Spheroid Invasion Matrix is a proprietary extracellular matrix blend comprised of basement membrane extract, derived from murine EHS sarcoma cells, and collagen I, from bovine extensor tendons. This matrix forms a hydrogel network on which invasive cells can travel out of a preformed spheroid. Cell invasion is visualized microscopically and can be quantified through image analysis software.
For research use only. Not for diagnostic use.
Embedding Spheroids in Cultrex BME for Cell Invasion and Migration Assays. MDA-MB-231 (3,000 cells/well) formed spheroids in low adhesion plates for 72 hours using reagents in the Cultrex 3-D Spheroid Basement Membrane Extract Cell Invasion Assay (Catalog # 3500-096-K). Briefly MDA-MB-231 cells were cultured in the presence of 1X Spheroid Formation Matrix (Catalog # 3500-096-01). Then spheroids were embedded in A) no Invasion Matrix, or B) Spheroid Invasion Matrix (Catalog # 3500-096-03). After hydrogel polymerization, DMEM and 10% FBS was added to each well to promote a chemotactic response over a 96 hour period. Note the addition of the Spheroid Invasion Matrix enhanced cell invasion over spheroids cultured without embedding in the invasion matrix.
Citations for Cultrex Spheroid Invasion Extracellular Matrix
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Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma
Authors: SW Choi, Y Lee, K Shin, H Koo, D Kim, JK Sa, HJ Cho, HM Shin, SJ Lee, H Kim, S Chung, J Shin, C Lee, DH Nam
Cell Death & Disease, 2021;12(4):374. 2021
Tumor Treating Fields (TTFields) Hinder Cancer Cell Motility through Regulation of Microtubule and Acting Dynamics
Authors: T Voloshin, RS Schneiderm, A Volodin, RR Shamir, N Kaynan, E Zeevi, L Koren, A Klein-Gold, R Paz, M Giladi, Z Bomzon, U Weinberg, Y Palti
Cancers (Basel), 2020;12(10):. 2020
DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/&beta-catenin signaling and cancer stem cell traits
Authors: HC Chi, CY Tsai, CS Wang, HY Yang, CH Lo, WJ Wang, KF Lee, LY Lai, JH Hong, YF Chang, MM Tsai, CT Yeh, CH Wu, CC Hsieh, LH Wang, WJ Chen, KH Lin
Oncogene, 2020;0(0):. 2020
Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms
Authors: S Featherby, YP Xiao, C Ettelaie, LL Nikitenko, J Greenman, A Maraveyas
Sci Rep, 2019;9(1):6272. 2019
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