Cultrex Spheroid Invasion Extracellular Matrix
Cultrex Spheroid Invasion Extracellular Matrix Summary
Provides a specialized extracellular matrix that is optimized to drive invasion of cells out of the preformed spheroids as a part of the Cultrex 3-D Culture Spheroid Cell Invasion Assay.Why Use Cultrex Spheroid Invasion Extracellular Matrix?
The Cultrex Spheroid Invasion Matrix is a proprietary extracellular matrix blend comprised of basement membrane extract, derived from murine EHS sarcoma cells, and collagen I, from bovine extensor tendons. This matrix forms a hydrogel network on which invasive cells can travel out of a preformed spheroid. Cell invasion is visualized microscopically and can be quantified through image analysis software.
Specifications
Limitations
For research use only. Not for diagnostic use.
Product Datasheets
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Data Example
Embedding Spheroids in Cultrex BME for Cell Invasion and Migration Assays. MDA-MB-231 (3,000 cells/well) formed spheroids in low adhesion plates for 72 hours using reagents in the Cultrex 3-D Spheroid Basement Membrane Extract Cell Invasion Assay (Catalog # 3500-096-K). Briefly MDA-MB-231 cells were cultured in the presence of 1X Spheroid Formation Matrix (Catalog # 3500-096-01). Then spheroids were embedded in A) no Invasion Matrix, or B) Spheroid Invasion Matrix (Catalog # 3500-096-03). After hydrogel polymerization, DMEM and 10% FBS was added to each well to promote a chemotactic response over a 96 hour period. Note the addition of the Spheroid Invasion Matrix enhanced cell invasion over spheroids cultured without embedding in the invasion matrix.
Citations for Cultrex Spheroid Invasion Extracellular Matrix
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma
Authors: SW Choi, Y Lee, K Shin, H Koo, D Kim, JK Sa, HJ Cho, HM Shin, SJ Lee, H Kim, S Chung, J Shin, C Lee, DH Nam
Cell Death & Disease, 2021;12(4):374. 2021
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Tumor Treating Fields (TTFields) Hinder Cancer Cell Motility through Regulation of Microtubule and Acting Dynamics
Authors: T Voloshin, RS Schneiderm, A Volodin, RR Shamir, N Kaynan, E Zeevi, L Koren, A Klein-Gold, R Paz, M Giladi, Z Bomzon, U Weinberg, Y Palti
Cancers (Basel), 2020;12(10):. 2020
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DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/&beta-catenin signaling and cancer stem cell traits
Authors: HC Chi, CY Tsai, CS Wang, HY Yang, CH Lo, WJ Wang, KF Lee, LY Lai, JH Hong, YF Chang, MM Tsai, CT Yeh, CH Wu, CC Hsieh, LH Wang, WJ Chen, KH Lin
Oncogene, 2020;0(0):. 2020
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Low molecular weight heparin and direct oral anticoagulants influence tumour formation, growth, invasion and vascularisation by separate mechanisms
Authors: S Featherby, YP Xiao, C Ettelaie, LL Nikitenko, J Greenman, A Maraveyas
Sci Rep, 2019;9(1):6272. 2019
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