Cyclopiazonic acid (CAS 18172-33-3): R&D Systems
Catalog Number: 1235
Alternate Names: α-Cyclopiazonic acid
Chemical Name: (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one
Biological Activity
Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.
Technical Data
  • M.Wt:
    336.39
  • Formula:
    C20H20N2O3
  • Solubility:
    Soluble to 5 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    18172-33-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cyclopiazonic acid effect on Ca2+-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover.
    Soler et al.
    Biochemistry, 1998;37:4266
  2. On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca2+-ATPases by cyclopiazonic acid.
    Plenge-Tellechea et al.
    J.Biol.Chem., 1997;272:2794
  3. Comparison of contractions produced by carbachol, thapsigargin and cyclopiazonic acid in the guinea-pig tracheal muscle.
    Takemoto et al.
    Br.J.Pharmacol., 1998;124:1449

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