Lgr4, also called GPR48, is a 7TM receptor that forms complexes with R-Spondins, Frizzled Wnt receptors and LRP Wnt co-receptors. It enhances Wnt-dependent LRP phosphorylation, internalization of LRPs, and accumulation of beta-catenin. Rodent Lgr4 is widely expressed in both embryo and adult. Lgr4 deletion inhibits fetal liver definitive erythropoiesis, arrests germ cell meiosis, induces loss of intestinal crypts, and leads to hyperactive inflammatory responses. Lgr4 may be overexpressed in carcinomas and may promote invasiveness and metastasis by downregulating p27Kip1 expression.
Cynomolgus Monkey Lgr4/GPR48 (unique) VersaClone cDNA
R&D Systems | Catalog # RDC2519
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Lgr4/GPR48
Long Name
Leucine-rich Repeat Containing G Protein-coupled Receptor 4
Alternate Names
GPR48
Gene Symbol
LGR4
UniProt
Additional Lgr4/GPR48 Products
Product Documents for Cynomolgus Monkey Lgr4/GPR48 (unique) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Cynomolgus Monkey Lgr4/GPR48 (unique) VersaClone cDNA
For research use only
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