Catalog Number: 0106
Alternate Names: 2-APV, D-APV, D-2-amino-5-phosphonovalerate
Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid
Biological Activity
Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer, L-AP5 (Cat. No. 0107). Also available as part of the Mixed NMDA Receptor Tocriset™ or as a mixed isomer DL-AP5 (Cat. No. 0105).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
    Schulte et al.
    Brain Res., 1994;649:203
  2. Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
    Davies and Watkins
    Brain Res., 1982;235:378
  3. The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
    Evans et al.
    Br.J.Pharmacol., 1982;75:65

The citations listed below are publications that use Tocris products. Selected citations for D-AP5 include:

Showing Results 1 - 10 of 277

  1. Feeding induced by cannabinoids is mediated independently of the melanocortin system.
    Authors: Sinnayah Et al.
    PLoS One
  2. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci
  3. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurosci
  4. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
    Authors: Dennis Et al.
    Cereb Cortex
  5. Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih.
    Authors: Williams and Hablitz
    Front Cell Neurosci
  6. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.
    Authors: Costa Et al.
    Front Behav Neurosci
  7. Norepinephrine Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
    Authors: Ghosh Et al.
    Front Cell Neurosci
  8. A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP.
    Authors: Lamanna Et al.
    Front Cell Neurosci
  9. Dendritic morphology, synaptic transmission, and activity of mature granule cells born following pilocarpine-induced status epilepticus in the rat.
    Authors: Gao Et al.
    Front Cell Neurosci
  10. GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
    Authors: Arama Et al.
    Front Cell Neurosci
  11. Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
    Authors: Baltz and Voigt
    Front Cell Neurosci
  12. Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
    Authors: Park Et al.
    Mol Brain
  13. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
    Authors: Campbell Et al.
    Front Cell Neurosci
  14. Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.
    Authors: Lee Et al.
    Mol Brain
  15. Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
    Authors: Eckel Et al.
  16. LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.
    Authors: Telese Et al.
  17. Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
    Authors: Birnbaum Et al.
    Cell Death Dis
  18. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    Cell Death Dis
  19. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
    Authors: Ciani Et al.
    Nat Commun
  20. Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
    Authors: Morini Et al.
    Stem Cell Res Ther
  21. Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo.
    Authors: Haselmann Et al.
    Front Neurol
  22. MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.
    Authors: Hou Et al.
    Nat Commun
  23. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
  24. GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy.
    Authors: Campbell Et al.
  25. Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor κ B.
    Authors: Sharma Et al.
    Sci Rep
  26. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
    Authors: Tang Et al.
    Sci Rep
  27. Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
    Authors: Malvaez Et al.
    Sci Rep
  28. Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain.
    Authors: Pardi Et al.
  29. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
  30. AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae.
    Authors: Sengupta and Thirumalai
  31. Retroactive modulation of spike timing-dependent plasticity by dopamine.
    Authors: Brzosko Et al.
  32. Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
    Authors: Duménieu Et al.
    Physiol Rep
  33. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci
  34. An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.
    Authors: Morrie and Feller
    J Neurosci
  35. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
    Authors: Puranam Et al.
    J Neurosci
  36. Developmental changes in synaptic distribution in arcuate nucleus neurons.
    Authors: Baquero Et al.
    J Neurosci
  37. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    J Neurosci
  38. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    J Neurosci
  39. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons.
    Authors: Zhong Et al.
    J Neurosci
  40. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci
  41. Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
    Authors: Stephen Et al.
    J Neurosci
  42. Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
    Authors: Sobieski Et al.
    J Neurosci
  43. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
  44. Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
    Authors: Medrihan Et al.
    Cereb Cortex
  45. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci
  46. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
    Authors: Vossel Et al.
    J Cell Biol
  47. Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus.
    Authors: Savotchenko Et al.
    Neural Plast
  48. Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
    Authors: Cooke Et al.
    Nat Neurosci
  49. Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
    Authors: John Et al.
    Brain Res
  50. The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats.
    Authors: Li Et al.
  51. The rat retina has five types of ganglion-cell photoreceptors.
    Authors: Reifler Et al.
    Exp Eye Res
  52. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Nat Methods
  53. Paclitaxel induces acute pain via directly activating toll like receptor 4.
    Authors: Yan Et al.
    Mol Pain
  54. Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.
    Authors: Dorris Et al.
    J Neurophysiol
  55. Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
    Authors: Xue Et al.
    Proc Natl Acad Sci U S A
  56. Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
    Authors: Kardamakis Et al.
    Proc Natl Acad Sci U S A
  57. ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
    Authors: Noh Et al.
    Proc Natl Acad Sci U S A
  58. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
    Authors: Toda and Huganir
    Proc Natl Acad Sci U S A
  59. Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
    Authors: Tseng Et al.
    Proc Natl Acad Sci U S A
  60. Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
    Authors: Wang Et al.
    PLoS One
  61. Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
    Authors: Taylor-Burds Et al.
    PLoS One
  62. G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.
    Authors: Sexton and Gelder
    PLoS One
  63. The effect of desflurane on neuronal communication at a central synapse.
    Authors: Mapelli Et al.
    PLoS One
  64. Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins.
    Authors: Hososhima Et al.
    PLoS One
  65. α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons.
    Authors: Hodges Et al.
    PLoS One
  66. Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse.
    Authors: Albrecht Et al.
    Front Neural Circuits
  67. Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling.
    Authors: Chuhma Et al.
  68. HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.
    Authors: Varodayan and Harrison
    Front Integr Neurosci
  69. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    Front Mol Neurosci
  70. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
  71. Quantitative profiling of peptides from RNAs classified as noncoding.
    Authors: Prabakaran Et al.
    Nat Commun
  72. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
    Authors: Lee Et al.
    Philos Trans R Soc Lond B Biol Sci
  73. Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
    Authors: Armbrust Et al.
    J Neurosci
  74. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
    Authors: Ivanov Et al.
    J Cereb Blood Flow Metab
  75. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
    Authors: Blanco-Suárez Et al.
    J Cereb Blood Flow Metab
  76. A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
    Authors: Crook Et al.
    Vis Neurosci
  77. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aβ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aβ agents.
    Authors: Qi Et al.
    Acta Neuropathol Commun
  78. Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
    Authors: Dale Et al.
    J Psychopharmacol
  79. Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
    Authors: Gaffaney Et al.
    Mol Biol Cell
  80. Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria.
    Authors: Wang Et al.
    Cereb Cortex
  81. Isoliquiritigenin, a chalcone compound, enhances spontaneous inhibitory postsynaptic response.
    Authors: Woo Et al.
    Exp Neurobiol
  82. Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.
    Authors: Cijsouw Et al.
    J Cell Biol
  83. Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities.
    Authors: Mohn Et al.
    Mol Psychiatry
  84. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
    Authors: Bemben Et al.
    Nat Neurosci
  85. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol
  86. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors.
    Authors: Ady Et al.
    EMBO Rep
  87. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
    Authors: Simma Et al.
    Cell Commun Signal
  88. Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
    Authors: Pan Et al.
    J Clin Invest
  89. Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function.
    Authors: Ostrowski Et al.
    J Neurophysiol
  90. GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
    Authors: Berlinguer-Palmini Et al.
    PLoS One
  91. Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice.
    Authors: Yu Et al.
    PLoS One
  92. Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit.
    Authors: Neuser Et al.
    PLoS One
  93. Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons.
    Authors: Alpert and Alford
    PLoS One
  94. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    PLoS One
  95. Contribution of NMDA receptor hypofunction in prefrontal and cortical excitatory neurons to schizophrenia-like phenotypes.
    Authors: Rompala Et al.
    PLoS One
  96. Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
    Authors: Song Et al.
    Front Cell Neurosci
  97. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
    Authors: Ferando and Mody
    Front Neural Circuits
  98. Intersecting circuits generate precisely patterned retinal waves.
    Authors: Akrouh and Kerschensteiner
  99. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain
  100. Postsynaptic protein synthesis is required for presynaptic enhancement in persistent forms of long-term potentiation.
    Authors: Johnstone and Raymond
    Front Synaptic Neurosci
  101. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    Neurobiol Dis
  102. Cortical interneurons that specialize in disinhibitory control.
    Authors: Pi Et al.
  103. Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
    Authors: Medrihan Et al.
    Nat Commun
  104. Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala.
    Authors: Cruz Et al.
  105. Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by microRNA miR-146a-5p.
    Authors: Chen and Shen
    J Neurosci
  106. A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex.
    Authors: Yoshii Et al.
    J Neurosci
  107. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
    Authors: Chen Et al.
    J Neurosci
  108. Axonal translation of β-catenin regulates synaptic vesicle dynamics.
    Authors: Taylor Et al.
    J Neurosci
  109. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    J Neurosci
  110. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    J Neurosci
  111. Locally-generated Acetaldehyde Contributes to the Effects of Ethanol on Neurosteroids and LTP in the Hippocampus.
    Authors: Tokuda Et al.
    Neurol Clin Neurosci
  112. Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
    Authors: Korb Et al.
    Nat Neurosci
  113. Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices.
    Authors: Yamagata Et al.
    Brain Res
  114. Fast neurotransmitter release regulated by the endocytic scaffold intersectin.
    Authors: Sakaba Et al.
    Proc Natl Acad Sci U S A
  115. Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
    Authors: Villers Et al.
    PLoS One
  116. Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
    Authors: Platt Et al.
    PLoS One
  117. Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.
    Authors: Lethbridge Et al.
    PLoS One
  118. Opposing Effects of Intrinsic Conductance and Correlated Synaptic Input on V-Fluctuations during Network Activity.
    Authors: Kolind Et al.
    Front Comput Neurosci
  119. Human glioma cells induce hyperexcitability in cortical networks.
    Authors: Campbell Et al.
  120. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
    Authors: Udagawa Et al.
    Mol Cell
  121. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
    Authors: Rodríguez-Muñoz Et al.
  122. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
    Authors: He Et al.
  123. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    Eur J Neurosci
  124. Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons.
    Authors: Guo Et al.
  125. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci
  126. GABA is excitatory in adult vasopressinergic neuroendocrine cells.
    Authors: Haam Et al.
    J Neurosci
  127. The mode of retinal presynaptic inhibition switches with light intensity.
    Authors: Ichinose and Lukasiewicz
    J Neurosci
  128. Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
    Authors: Janssen Et al.
    J Neurosci
  129. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
    Authors: Crawford Et al.
    J Neurosci
  130. Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism.
    Authors: Lemos Et al.
    J Neurosci
  131. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci
  132. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
    Authors: Saliba Et al.
    EMBO J
  133. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep
  134. NMDA receptors and BAX are essential for Aβ impairment of LTP.
    Authors: Olsen and Sheng
    Sci Rep
  135. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
    Authors: Daftary Et al.
  136. Munc13 controls the location and efficiency of dense-core vesicle release in neurons.
    Authors: Bospoort Et al.
    J Cell Biol
  137. Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala.
    Authors: Bajo Et al.
    Addict Biol
  138. K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
    Authors: Heinrich Et al.
    Br J Pharmacol
  139. Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.
    Authors: Yao Et al.
    Nat Neurosci
  140. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers.
    Authors: Tang Et al.
  141. Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy.
    Authors: Upreti Et al.
  142. Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.
    Authors: Navarrete Et al.
    PLoS Biol
  143. Age-dependent effect of hearing loss on cortical inhibitory synapse function.
    Authors: Takesian Et al.
    J Neurophysiol
  144. A critical role for GluN2B-containing NMDA receptors in cortical development and function.
    Authors: Wang Et al.
  145. Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
    Authors: Zhang and Sun
    Dev Neurobiol
  146. Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat.
    Authors: Case Et al.
    PLoS One
  147. Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons.
    Authors: Uschakov Et al.
    PLoS One
  148. 11-Deoxycortisol impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice.
    Authors: Kaminski Et al.
  149. Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro.
    Authors: Randall Et al.
    Eur J Neurosci
  150. Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses.
    Authors: Crawford Et al.
    J Neurosci
  151. Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function.
    Authors: Bateup Et al.
    J Neurosci
  152. Molecular determinants controlling NMDA receptor synaptic incorporation.
    Authors: Storey Et al.
    J Neurosci
  153. Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.
    Authors: Mark Et al.
    J Neurosci
  154. Attenuating GABA(A) receptor signaling in dopamine neurons selectively enhances reward learning and alters risk preference in mice.
    Authors: Parker Et al.
    J Neurosci
  155. Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice.
    Authors: Pan Et al.
    J Neurosci
  156. Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
    Authors: Lazarevic Et al.
    J Neurosci
  157. An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
    Authors: Etherton Et al.
    EMBO J
  158. Rapid developmental maturation of neocortical FS cell intrinsic excitability.
    Authors: Goldberg Et al.
    Cereb Cortex
  159. Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
    Authors: Mahajan Et al.
  160. Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex.
    Authors: Zhang Et al.
  161. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
    Authors: Straub Et al.
    Nat Neurosci
  162. Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization.
    Authors: Christie Et al.
    Nat Neurosci
  163. Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition.
    Authors: Zhu Et al.
  164. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem
  165. PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons.
    Authors: Werner Et al.
    J Neurochem
  166. Regulation of synaptic stability by AMPA receptor reverse signaling.
    Authors: Ripley Et al.
    Proc Natl Acad Sci U S A
  167. A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam.
    Authors: Meehan Et al.
    J Neurophysiol
  168. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
    Authors: Ali
    J Neurophysiol
  169. Systematic heterogeneity of fractional vesicle pool sizes and release rates of hippocampal synapses.
    Authors: Welzel Et al.
    Biophys J
  170. An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
    Authors: Gómez-Gonzalo Et al.
    PLoS Biol
  171. SV2 mediates entry of tetanus neurotoxin into central neurons.
    Authors: Yeh Et al.
    PLoS Pathog
  172. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
  173. Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo.
    Authors: Chen Et al.
  174. Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons.
    Authors: Dimitrov and Usdin
    J Comp Neurol
  175. High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum.
    Authors: Mapelli Et al.
    Front Cell Neurosci
  176. MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
    Authors: Tian Et al.
    Mol Cell Neurosci
  177. Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses.
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