Catalog Number: 0106
Alternate Names: 2-APV, D-APV, D-2-amino-5-phosphonovalerate
Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid
Biological Activity
Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer, L-AP5.

Available as part of the Mixed NMDA Receptor Tocriset™. DL Mixture and L-isomer also available.

Technical Data
  • M.Wt:
    197.13
  • Formula:
    C5H12NO5P
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    79055-68-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
    Schulte et al.
    Brain Res., 1994;649:203
  2. Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
    Davies and Watkins
    Brain Res., 1982;235:378
  3. The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
    Evans et al.
    Br.J.Pharmacol., 1982;75:65
Citations:

The citations listed below are publications that use Tocris products. Selected citations for D-AP5 include:

283 Citations: Showing 1 - 10
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  1. Feeding induced by cannabinoids is mediated independently of the melanocortin system.
    Authors: Sinnayah Et al.
    PLoS One ;3:e2202
  2. Differential processing of thalamic information via distinct striatal interneuron circuits.
    Authors: Assous
    Nat Commun 2017;8:15860
  3. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell 2017;16(6):1323
  4. Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
    Authors: Kashima and Grueter
    Proc Natl Acad Sci U S A. 2017;114(3):8865
  5. Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
    Authors: Imlach Et al.
    Scientific Reports 2016;6:37104?
  6. Increased GABAB receptor signaling in a rat model for schizophrenia
    Authors: Selten Et al.
    Scientific Reports 2016;6:34240
  7. A cholinergic basal forebrain feeding circuit modulates appetite suppression
    Authors: Herman Et al.
    Nature 2016;538:253
  8. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci 2016;36:622
  9. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurosci 2016;36:607
  10. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
    Authors: Dennis Et al.
    Cereb Cortex 2016;26:414
  11. Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih.
    Authors: Williams and Hablitz
    Front Cell Neurosci 2015;9:89
  12. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.
    Authors: Costa Et al.
    Front Behav Neurosci 2015;9:65
  13. Norepinephrine Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
    Authors: Ghosh Et al.
    Front Cell Neurosci 2015;9:450
  14. A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP.
    Authors: Lamanna Et al.
    Front Cell Neurosci 2015;9:44
  15. Dendritic morphology, synaptic transmission, and activity of mature granule cells born following pilocarpine-induced status epilepticus in the rat.
    Authors: Gao Et al.
    Front Cell Neurosci 2015;9:384
  16. GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
    Authors: Arama Et al.
    Front Cell Neurosci 2015;9:290
  17. Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
    Authors: Baltz and Voigt
    Front Cell Neurosci 2015;9:272
  18. Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
    Authors: Park Et al.
    Mol Brain 2015;8:7
  19. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
    Authors: Campbell Et al.
    Front Cell Neurosci 2015;8:425
  20. Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.
    Authors: Lee Et al.
    Mol Brain 2015;8:38
  21. Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
    Authors: Eckel Et al.
    Neuropharmacology 2015;88:82
  22. LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.
    Authors: Telese Et al.
    Neuron 2015;86:696
  23. Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
    Authors: Birnbaum Et al.
    Cell Death Dis 2015;6:e1791
  24. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    Cell Death Dis 2015;6:e1645
  25. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
    Authors: Ciani Et al.
    Nat Commun 2015;6:8302
  26. Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
    Authors: Morini Et al.
    Stem Cell Res Ther 2015;6:166
  27. Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo.
    Authors: Haselmann Et al.
    Front Neurol 2015;6:136
  28. MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.
    Authors: Hou Et al.
    Nat Commun 2015;6:10045
  29. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Glia 2015;63:383
  30. GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy.
    Authors: Campbell Et al.
    Glia 2015;63:23
  31. Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor κ B.
    Authors: Sharma Et al.
    Sci Rep 2015;5:16616
  32. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
    Authors: Tang Et al.
    Sci Rep 2015;5:14099
  33. Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
    Authors: Malvaez Et al.
    Sci Rep 2015;5:12511
  34. Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain.
    Authors: Pardi Et al.
    Elife 2015;4:e08764
  35. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    Elife 2015;4
  36. Retroactive modulation of spike timing-dependent plasticity by dopamine.
    Authors: Brzosko Et al.
    Elife 2015;4
  37. AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae.
    Authors: Sengupta and Thirumalai
    Elife 2015;4
  38. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci 2015;35:9580
  39. An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.
    Authors: Morrie and Feller
    J Neurosci 2015;35:9281
  40. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
    Authors: Puranam Et al.
    J Neurosci 2015;35:8866
  41. Developmental changes in synaptic distribution in arcuate nucleus neurons.
    Authors: Baquero Et al.
    J Neurosci 2015;35:8558
  42. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    J Neurosci 2015;35:621
  43. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    J Neurosci 2015;35:5664
  44. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons.
    Authors: Zhong Et al.
    J Neurosci 2015;35:4469
  45. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci 2015;35:3652
  46. Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
    Authors: Stephen Et al.
    J Neurosci 2015;35:15996
  47. Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
    Authors: Sobieski Et al.
    J Neurosci 2015;35:11105
  48. Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
    Authors: Duménieu Et al.
    Physiol Rep 2015;3
  49. Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
    Authors: Medrihan Et al.
    Cereb Cortex 2015;25:3356
  50. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci 2015;22:79
  51. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
    Authors: Vossel Et al.
    J Cell Biol 2015;209:419
  52. Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus.
    Authors: Savotchenko Et al.
    Neural Plast 2015;2015:908190
  53. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    Eneuro 2015;2
  54. Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
    Authors: Cooke Et al.
    Nat Neurosci 2015;18:262
  55. Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
    Authors: John Et al.
    Brain Res 2015;1601:15
  56. The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats.
    Authors: Li Et al.
    Endocrinology 2015;156:3725
  57. The rat retina has five types of ganglion-cell photoreceptors.
    Authors: Reifler Et al.
    Exp Eye Res 2015;130:17
  58. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Nat Methods 2015;12:671
  59. Paclitaxel induces acute pain via directly activating toll like receptor 4.
    Authors: Yan Et al.
    Mol Pain 2015;11:10
  60. Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.
    Authors: Dorris Et al.
    J Neurophysiol 2015;113:720
  61. Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
    Authors: Xue Et al.
    Proc Natl Acad Sci U S A 2015;112:E4316
  62. Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
    Authors: Kardamakis Et al.
    Proc Natl Acad Sci U S A 2015;112:E1956
  63. ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
    Authors: Noh Et al.
    Proc Natl Acad Sci U S A 2015;112:6820
  64. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
    Authors: Toda and Huganir
    Proc Natl Acad Sci U S A 2015;112:6712
  65. Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
    Authors: Tseng Et al.
    Proc Natl Acad Sci U S A 2015;112:1214
  66. Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
    Authors: Wang Et al.
    PLoS One 2015;10:e0139332
  67. Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
    Authors: Taylor-Burds Et al.
    PLoS One 2015;10:e0131076
  68. G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.
    Authors: Sexton and Gelder
    PLoS One 2015;10:e0128690
  69. The effect of desflurane on neuronal communication at a central synapse.
    Authors: Mapelli Et al.
    PLoS One 2015;10:e0123534
  70. Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins.
    Authors: Hososhima Et al.
    PLoS One 2015;10:e0119558
  71. α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons.
    Authors: Hodges Et al.
    PLoS One 2014;9:e101770
  72. Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse.
    Authors: Albrecht Et al.
    Front Neural Circuits 2014;8:83
  73. Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling.
    Authors: Chuhma Et al.
    Neuron 2014;81:901
  74. HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.
    Authors: Varodayan and Harrison
    Front Integr Neurosci 2014;7:89
  75. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    Front Mol Neurosci 2014;7:62
  76. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic memantine treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    Neuropharmacology 2014;77:379
  77. Quantitative profiling of peptides from RNAs classified as noncoding.
    Authors: Prabakaran Et al.
    Nat Commun 2014;5:5429
  78. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
    Authors: Lee Et al.
    Philos Trans R Soc Lond B Biol Sci 2014;369:20130158
  79. Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
    Authors: Armbrust Et al.
    J Neurosci 2014;34:9891
  80. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
    Authors: Ivanov Et al.
    J Cereb Blood Flow Metab 2014;34:397
  81. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
    Authors: Blanco-Suárez Et al.
    J Cereb Blood Flow Metab 2014;34:1898
  82. A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
    Authors: Crook Et al.
    Vis Neurosci 2014;31:57
  83. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aβ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aβ agents.
    Authors: Qi Et al.
    Acta Neuropathol Commun 2014;2:175
  84. Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
    Authors: Dale Et al.
    J Psychopharmacol 2014;28:891
  85. Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
    Authors: Gaffaney Et al.
    Mol Biol Cell 2014;25:481
  86. Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria.
    Authors: Wang Et al.
    Cereb Cortex 2014;24:1088
  87. Isoliquiritigenin, a chalcone compound, enhances spontaneous inhibitory postsynaptic response.
    Authors: Woo Et al.
    Exp Neurobiol 2014;23:163
  88. Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.
    Authors: Cijsouw Et al.
    J Cell Biol 2014;204:759
  89. Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities.
    Authors: Mohn Et al.
    Mol Psychiatry 2014;19:1133
  90. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
    Authors: Bemben Et al.
    Nat Neurosci 2014;17:56
  91. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol 2014;17:1943
  92. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors.
    Authors: Ady Et al.
    EMBO Rep 2014;15:103
  93. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
    Authors: Simma Et al.
    Cell Commun Signal 2014;12:75
  94. Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
    Authors: Pan Et al.
    J Clin Invest 2014;124:4629
  95. Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function.
    Authors: Ostrowski Et al.
    J Neurophysiol 2014;111:2493
  96. GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
    Authors: Berlinguer-Palmini Et al.
    PLoS One 2013;8:e82180
  97. Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice.
    Authors: Yu Et al.
    PLoS One 2013;8:e76049
  98. Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit.
    Authors: Neuser Et al.
    PLoS One 2013;8:e66497
  99. Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons.
    Authors: Alpert and Alford
    PLoS One 2013;8:e63154
  100. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    PLoS One 2013;8:e61787
  101. Contribution of NMDA receptor hypofunction in prefrontal and cortical excitatory neurons to schizophrenia-like phenotypes.
    Authors: Rompala Et al.
    PLoS One 2013;8:e61278
  102. Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
    Authors: Song Et al.
    Front Cell Neurosci 2013;7:23
  103. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
    Authors: Ferando and Mody
    Front Neural Circuits 2013;7:144
  104. Intersecting circuits generate precisely patterned retinal waves.
    Authors: Akrouh and Kerschensteiner
    Neuron 2013;79:322
  105. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain 2013;6:42
  106. Postsynaptic protein synthesis is required for presynaptic enhancement in persistent forms of long-term potentiation.
    Authors: Johnstone and Raymond
    Front Synaptic Neurosci 2013;5:1
  107. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    Neurobiol Dis 2013;59:42736
  108. Cortical interneurons that specialize in disinhibitory control.
    Authors: Pi Et al.
    Nature 2013;503:521
  109. Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
    Authors: Medrihan Et al.
    Nat Commun 2013;4:1512
  110. Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala.
    Authors: Cruz Et al.
    Neuropsychopharmacology 2013;38:364
  111. Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by microRNA miR-146a-5p.
    Authors: Chen and Shen
    J Neurosci 2013;33:9013
  112. A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex.
    Authors: Yoshii Et al.
    J Neurosci 2013;33:8472
  113. The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
    Authors: Chen Et al.
    J Neurosci 2013;33:8336
  114. Axonal translation of β-catenin regulates synaptic vesicle dynamics.
    Authors: Taylor Et al.
    J Neurosci 2013;33:5584
  115. TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
    Authors: Pribiag and Stellwagen
    J Neurosci 2013;33:15879
  116. An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
    Authors: Siddoway Et al.
    J Neurosci 2013;33:11206
  117. Locally-generated Acetaldehyde Contributes to the Effects of Ethanol on Neurosteroids and LTP in the Hippocampus.
    Authors: Tokuda Et al.
    Neurol Clin Neurosci 2013;1:138
  118. Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
    Authors: Korb Et al.
    Nat Neurosci 2013;16:874
  119. Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices.
    Authors: Yamagata Et al.
    Brain Res 2013;1507:1
  120. Fast neurotransmitter release regulated by the endocytic scaffold intersectin.
    Authors: Sakaba Et al.
    Proc Natl Acad Sci U S A 2013;110:8266
  121. Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
    Authors: Villers Et al.
    PLoS One 2012;7:e40823
  122. Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
    Authors: Platt Et al.
    PLoS One 2012;7:e36397
  123. Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.
    Authors: Lethbridge Et al.
    PLoS One 2012;7:e35024
  124. Opposing Effects of Intrinsic Conductance and Correlated Synaptic Input on V-Fluctuations during Network Activity.
    Authors: Kolind Et al.
    Front Comput Neurosci 2012;6:40
  125. Human glioma cells induce hyperexcitability in cortical networks.
    Authors: Campbell Et al.
    Epilepsia 2012;53:1360
  126. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
    Authors: Udagawa Et al.
    Mol Cell 2012;47:253
  127. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
    Authors: Rodríguez-Muñoz Et al.
    Neuropsychopharmacology 2012;37:338
  128. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
    Authors: He Et al.
    Neuropsychopharmacology 2012;37:1338
  129. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    Eur J Neurosci 2012;35:507
  130. Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons.
    Authors: Guo Et al.
    Biomaterials 2012;33:5723
  131. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci 2012;32:8127
  132. GABA is excitatory in adult vasopressinergic neuroendocrine cells.
    Authors: Haam Et al.
    J Neurosci 2012;32:572
  133. The mode of retinal presynaptic inhibition switches with light intensity.
    Authors: Ichinose and Lukasiewicz
    J Neurosci 2012;32:4360
  134. Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
    Authors: Janssen Et al.
    J Neurosci 2012;32:13889
  135. Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
    Authors: Crawford Et al.
    J Neurosci 2012;32:13100
  136. Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism.
    Authors: Lemos Et al.
    J Neurosci 2012;32:12325
  137. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci 2012;32:10767
  138. Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
    Authors: Saliba Et al.
    EMBO J 2012;31:2937
  139. Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
    Authors: Caiati Et al.
    Sci Rep 2012;2:285
  140. NMDA receptors and BAX are essential for Aβ impairment of LTP.
    Authors: Olsen and Sheng
    Sci Rep 2012;2:225
  141. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
    Authors: Daftary Et al.
    Neuroscience 2012;224:125
  142. Munc13 controls the location and efficiency of dense-core vesicle release in neurons.
    Authors: Bospoort Et al.
    J Cell Biol 2012;199:883
  143. Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala.
    Authors: Bajo Et al.
    Addict Biol 2012;17:694
  144. K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
    Authors: Heinrich Et al.
    Br J Pharmacol 2012;167:1003
  145. Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.
    Authors: Yao Et al.
    Nat Neurosci 2012;15:243
  146. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers.
    Authors: Tang Et al.
    Traffic 2012;13:681
  147. Altered neurotransmitter release, vesicle recycling and presynaptic structure in the pilocarpine model of temporal lobe epilepsy.
    Authors: Upreti Et al.
    Brain 2012;135:869
  148. Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.
    Authors: Navarrete Et al.
    PLoS Biol 2012;10:e1001259
  149. Age-dependent effect of hearing loss on cortical inhibitory synapse function.
    Authors: Takesian Et al.
    J Neurophysiol 2012;107:937
  150. A critical role for GluN2B-containing NMDA receptors in cortical development and function.
    Authors: Wang Et al.
    Neuron 2011;72:789
  151. Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
    Authors: Zhang and Sun
    Dev Neurobiol 2011;71:221
  152. Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat.
    Authors: Case Et al.
    PLoS One 2011;6:e20756
  153. Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons.
    Authors: Uschakov Et al.
    PLoS One 2011;6:e16672
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  191. Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
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  198. Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.
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  218. Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
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  219. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
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    Neuron 2008;57:746
  220. Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others.
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  221. Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I.
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  222. Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus.
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  223. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin.
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  224. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
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  234. N-arachidonoyl-dopamine tunes synaptic transmission onto dopaminergic neurons by activating both cannabinoid and vanilloid receptors.
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  235. Axon and dendrite geography predict the specificity of synaptic connections in a functioning spinal cord network.
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  239. Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.
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  240. Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
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  243. A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction.
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  244. Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms.
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    Proc Natl Acad Sci U S A 2007;104:353
  245. Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
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  249. Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth.
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  250. Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling.
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  254. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.
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    Neuron 2005;48:913
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