D-AP5

Catalog # Availability Size / Price Qty
0106/10
0106/50
0106/100
0106/1
NMDA Receptor Antagonists Small Molecule
1 Image
Description: Potent and selective NMDA antagonist; more active form of DL-AP5
Alternative Names: 2-APV, D-APV, D-2-amino-5-phosphonovalerate

Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid

Purity: ≥99%

Product Details
Citations (352)
Supplemental Products
Reviews (4)

Biological Activity

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer, L-AP5 (Cat. No.0107).

Available as part of the Mixed NMDA Receptor Tocriset™. DL Mixture and L-isomer also available.

Technical Data

M.Wt:
197.13
Formula:
C5H12NO5P
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
79055-68-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Product Datasheets

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Citations for D-AP5

The citations listed below are publications that use Tocris products. Selected citations for D-AP5 include:

352 Citations: Showing 1 - 10

  1. Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
    Authors: Woo Et al.
    Exp Neurobiol  2019;28:30
  2. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
    Authors: Nam Et al.
    Cell Rep  2019;28:1154
  3. High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
    Authors: Battefeld Et al.
    Cell Rep  2019;26:182
  4. Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
    Authors: Bülow Et al.
    Cell Rep  2019;26:1378
  5. KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
    Authors: Spoljaric Et al.
    Cell Rep  2019;26:1073
  6. Role of intraganglionic transmission in the trigeminovascular pathway.
    Authors: Zhang Et al.
    Mol Pain  2019;15:1744806919836570
  7. Simultaneous voltage and calcium imaging and optogenetic stimulation with high sensitivity and a wide field of view.
    Authors: Nguyen Et al.
    Biomed Opt Express  2019;10:789
  8. Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo.
    Authors: González-Rueda Et al.
    Neuron  2018;97:1244
  9. DA neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons.
    Authors: Chuhma Et al.
    Elife  2018;7
  10. Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.
    Authors: Smith Et al.
    Cell Rep  2018;25:278
  11. CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
    Authors: Dong Et al.
    Cell Rep  2018;24:284
  12. All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
    Authors: Fan Et al.
    Nat Methods  2018;15:823
  13. (2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
    Authors: Chou Et al.
    Neuropharmacology  2018;139:1
  14. Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction.
    Authors: Yasuda Et al.
    Front Cell Neurosci  2018;12:330
  15. Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall.
    Authors: Sun Et al.
    Neuron  2017;95:656
  16. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
    Authors: Medrihan Et al.
    Neuron  2017;95:564
  17. Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.
    Authors: Kim and Cho
    Neuron  2017;95:1129
  18. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
    Authors: Leroy Et al.
    Neuron  2017;95:1089
  19. IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.
    Authors: Liu Et al.
    Neuron  2017;95:106
  20. A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
    Authors: Li Et al.
    Neuron  2017;94:1155
  21. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
    Authors: Zhu Et al.
    Nat Commun  2017;8:1676
  22. Differential processing of thalamic information via distinct striatal interneuron circuits.
    Authors: Assous
    Nat Commun  2017;8:15860
  23. Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
    Authors: Leyrer-Jackson
    Physiol Rep  2017;5(22):e13499
  24. Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways.
    Authors: Pirbhoy Et al.
    Learn Mem  2017;24:341
  25. DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  26. Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
    Authors: Kashima and Grueter
    Proc Natl Acad Sci U S A.  2017;114(3):8865
  27. Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
    Authors: Pigott and Garthwaite
    Front Synaptic Neurosci  2016;8:17
  28. Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
    Authors: Imlach Et al.
    Scientific Reports  2016;6:37104
  29. Increased GABAB receptor signaling in a rat model for schizophrenia
    Authors: Selten Et al.
    Scientific Reports  2016;6:34240
  30. Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.
    Authors: Zhang Et al.
    Sci Rep  2016;6:28938
  31. Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
    Authors: Cui Et al.
    Elife  2016;5:e13185
  32. A cholinergic basal forebrain feeding circuit modulates appetite suppression
    Authors: Herman Et al.
    Nature  2016;538:253
  33. Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
    Authors: Park Et al.
    J Neurosci  2016;36:622
  34. Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
    Authors: Patel Et al.
    J Neurosci  2016;36:607
  35. Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization.
    Authors: Ishibashi Et al.
    J Neurosci  2016;36:10097
  36. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
    Authors: Dennis Et al.
    Cereb Cortex  2016;26:414
  37. Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains.
    Authors: Pirbhoy Et al.
    Learn Mem  2016;23:255
  38. Diminished KCC2 confounds synapse specificity of LTP during senescence.
    Authors: Ferando Et al.
    Nat Neurosci  2016;19:1197
  39. Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control.
    Authors: Pan Et al.
    J Clin Invest  2016;126:4516
  40. Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih.
    Authors: Williams and Hablitz
    Front Cell Neurosci  2015;9:89
  41. Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.
    Authors: Costa Et al.
    Front Behav Neurosci  2015;9:65
  42. NE Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
    Authors: Ghosh Et al.
    Front Cell Neurosci  2015;9:450
  43. A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP.
    Authors: Lamanna Et al.
    Front Cell Neurosci  2015;9:44
  44. Dendritic morphology, synaptic transmission, and activity of mature granule cells born following PilC-induced status epilepticus in the rat.
    Authors: Gao Et al.
    Front Cell Neurosci  2015;9:384
  45. GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
    Authors: Arama Et al.
    Front Cell Neurosci  2015;9:290
  46. Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
    Authors: Baltz and Voigt
    Front Cell Neurosci  2015;9:272
  47. Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
    Authors: Park Et al.
    Mol Brain  2015;8:7
  48. Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
    Authors: Campbell Et al.
    Front Cell Neurosci  2015;8:425
  49. Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.
    Authors: Lee Et al.
    Mol Brain  2015;8:38
  50. Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
    Authors: Eckel Et al.
    Neuropharmacology  2015;88:82
  51. LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.
    Authors: Telese Et al.
    Neuron  2015;86:696
  52. Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
    Authors: Birnbaum Et al.
    Cell Death Dis  2015;6:e1791
  53. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Authors: Curcio Et al.
    Cell Death Dis  2015;6:e1645
  54. Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
    Authors: Ciani Et al.
    Nat Commun  2015;6:8302
  55. Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
    Authors: Morini Et al.
    Stem Cell Res Ther  2015;6:166
  56. Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo.
    Authors: Haselmann Et al.
    Front Neurol  2015;6:136
  57. MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.
    Authors: Hou Et al.
    Nat Commun  2015;6:10045
  58. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
    Authors: Garthwaite Et al.
    Glia  2015;63:383
  59. GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy.
    Authors: Campbell Et al.
    Glia  2015;63:23
  60. Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor κ B.
    Authors: Sharma Et al.
    Sci Rep  2015;5:16616
  61. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
    Authors: Tang Et al.
    Sci Rep  2015;5:14099
  62. Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
    Authors: Malvaez Et al.
    Sci Rep  2015;5:12511
  63. Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain.
    Authors: Pardi Et al.
    Elife  2015;4:e08764
  64. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
    Authors: Rosa Et al.
    Elife  2015;4
  65. Retroactive modulation of spike timing-dependent plasticity by DA.
    Authors: Brzosko Et al.
    Elife  2015;4
  66. AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae.
    Authors: Sengupta and Thirumalai
    Elife  2015;4
  67. Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  68. An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.
    Authors: Morrie and Feller
    J Neurosci  2015;35:9281
  69. Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
    Authors: Puranam Et al.
    J Neurosci  2015;35:8866
  70. Developmental changes in synaptic distribution in arcuate nucleus neurons.
    Authors: Baquero Et al.
    J Neurosci  2015;35:8558
  71. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    J Neurosci  2015;35:621
  72. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    J Neurosci  2015;35:5664
  73. BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
    Authors: Zhong Et al.
    J Neurosci  2015;35:4469
  74. Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
    Authors: Dilger Et al.
    J Neurosci  2015;35:3652
  75. Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
    Authors: Stephen Et al.
    J Neurosci  2015;35:15996
  76. Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
    Authors: Sobieski Et al.
    J Neurosci  2015;35:11105
  77. Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
    Authors: Duménieu Et al.
    Physiol Rep  2015;3
  78. Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
    Authors: Galván Et al.
    Neuroscience  2015;290:332
  79. Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
    Authors: Medrihan Et al.
    Cereb Cortex  2015;25:3356
  80. Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
    Authors: Liu Et al.
    J Biomed Sci  2015;22:79
  81. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
    Authors: Vossel Et al.
    J Cell Biol  2015;209:419
  82. Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus.
    Authors: Savotchenko Et al.
    Neural Plast  2015;2015:908190
  83. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    Eneuro  2015;2
  84. Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
    Authors: Cooke Et al.
    Nat Neurosci  2015;18:262
  85. Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
    Authors: John Et al.
    Brain Res  2015;1601:15
  86. The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats.
    Authors: Li Et al.
    Endocrinology  2015;156:3725
  87. The rat retina has five types of ganglion-cell photoreceptors.
    Authors: Reifler Et al.
    Exp Eye Res  2015;130:17
  88. Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
    Authors: Pasca Et al.
    Nat Methods  2015;12:671
  89. PacT. induces acute pain via directly activating toll like receptor 4.
    Authors: Yan Et al.
    Mol Pain  2015;11:10
  90. Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.
    Authors: Dorris Et al.
    J Neurophysiol  2015;113:720
  91. Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
    Authors: Xue Et al.
    Proc Natl Acad Sci U S A  2015;112:E4316
  92. Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
    Authors: Kardamakis Et al.
    Proc Natl Acad Sci U S A  2015;112:E1956
  93. ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
    Authors: Noh Et al.
    Proc Natl Acad Sci U S A  2015;112:6820
  94. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
    Authors: Toda and Huganir
    Proc Natl Acad Sci U S A  2015;112:6712
  95. Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
    Authors: Tseng Et al.
    Proc Natl Acad Sci U S A  2015;112:1214
  96. Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
    Authors: Wang Et al.
    PLoS One  2015;10:e0139332
  97. Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
    Authors: Taylor-Burds Et al.
    PLoS One  2015;10:e0131076
  98. G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.
    Authors: Sexton and Gelder
    PLoS One  2015;10:e0128690
  99. The effect of Dflu. on neuronal communication at a central synapse.
    Authors: Mapelli Et al.
    PLoS One  2015;10:e0123534
  100. Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins.
    Authors: Hososhima Et al.
    PLoS One  2015;10:e0119558
  101. α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons.
    Authors: Hodges Et al.
    PLoS One  2014;9:e101770
  102. Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse.
    Authors: Albrecht Et al.
    Front Neural Circuits  2014;8:83
  103. Electrophysiological characterization of male goldfish (Carassius auratus) ventral preoptic area neurons receiving olfactory inputs.
    Authors: Lado Et al.
    Front Neurosci  2014;8:185
  104. DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling.
    Authors: Chuhma Et al.
    Neuron  2014;81:901
  105. HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.
    Authors: Varodayan and Harrison
    Front Integr Neurosci  2014;7:89
  106. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    Front Mol Neurosci  2014;7:62
  107. Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis.
    Authors: He and Bausch
    Neuropharmacology  2014;77:379
  108. Quantitative profiling of peptides from RNAs classified as noncoding.
    Authors: Prabakaran Et al.
    Nat Commun  2014;5:5429
  109. Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission.
    Authors: Accardi Et al.
    Nat Commun  2014;5:3168
  110. Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
    Authors: Lee Et al.
    Philos Trans R Soc Lond B Biol Sci  2014;369:20130158
  111. Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
    Authors: Armbrust Et al.
    J Neurosci  2014;34:9891
  112. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
    Authors: Ivanov Et al.
    J Cereb Blood Flow Metab  2014;34:397
  113. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
    Authors: Blanco-Suárez Et al.
    J Cereb Blood Flow Metab  2014;34:1898
  114. A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
    Authors: Crook Et al.
    Vis Neurosci  2014;31:57
  115. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aβ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aβ agents.
    Authors: Qi Et al.
    Acta Neuropathol Commun  2014;2:175
  116. Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
    Authors: Dale Et al.
    J Psychopharmacol  2014;28:891
  117. Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
    Authors: Gaffaney Et al.
    Mol Biol Cell  2014;25:481
  118. Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria.
    Authors: Wang Et al.
    Cereb Cortex  2014;24:1088
  119. Isoliquiritigenin, a chalcone compound, enhances spontaneous inhibitory postsynaptic response.
    Authors: Woo Et al.
    Exp Neurobiol  2014;23:163
  120. Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation.
    Authors: Villers Et al.
    Learn Mem  2014;21:616
  121. Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.
    Authors: Cijsouw Et al.
    J Cell Biol  2014;204:759
  122. Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities.
    Authors: Mohn Et al.
    Mol Psychiatry  2014;19:1133
  123. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
    Authors: Bemben Et al.
    Nat Neurosci  2014;17:56
  124. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol  2014;17:1943
  125. Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors.
    Authors: Ady Et al.
    EMBO Rep  2014;15:103
  126. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
    Authors: Simma Et al.
    Cell Commun Signal  2014;12:75
  127. Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
    Authors: Pan Et al.
    J Clin Invest  2014;124:4629
  128. Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function.
    Authors: Ostrowski Et al.
    J Neurophysiol  2014;111:2493
  129. Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats.
    Authors: Li Et al.
    J Neurophysiol  2014;111:145
  130. GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
    Authors: Berlinguer-Palmini Et al.
    PLoS One  2013;8:e82180
  131. Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice.
    Authors: Yu Et al.
    PLoS One  2013;8:e76049
  132. Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit.
    Authors: Neuser Et al.
    PLoS One  2013;8:e66497
  133. Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons.
    Authors: Alpert and Alford
    PLoS One  2013;8:e63154
  134. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    PLoS One  2013;8:e61787
  135. Contribution of NMDA receptor hypofunction in prefrontal and cortical excitatory neurons to schizophrenia-like phenotypes.
    Authors: Rompala Et al.
    PLoS One  2013;8:e61278
  136. Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
    Authors: Song Et al.
    Front Cell Neurosci  2013;7:23
  137. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
    Authors: Ferando and Mody
    Front Neural Circuits  2013;7:144
  138. Intersecting circuits generate precisely patterned retinal waves.
    Authors: Akrouh and Kerschensteiner
    Neuron  2013;79:322
  139. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
    Authors: Vicente-Sánchez Et al.
    Mol Brain  2013;6:42
  140. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
    Authors: Koeglsperger Et al.
    Glia  2013;61:985
  141. Postsynaptic protein synthesis is required for presynaptic enhancement in persistent forms of long-term potentiation.
    Authors: Johnstone and Raymond
    Front Synaptic Neurosci  2013;5:1
  142. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    Neurobiol Dis  2013;59:42736
  143. Cortical interneurons that specialize in disinhibitory control.
    Authors: Pi Et al.
    Nature  2013;503:521
  144. Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
    Authors: Medrihan Et al.
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Works as intended
By Anonymous on 05/14/2019
Species: Mouse

We delivered this drug intracranially in combination with DNQX to block glutamatergic transmission in the mouse VTA. Product was highly soluble and worked well and as described, producing a robust decrease in place preference behavior.

PMID: 27378337

Validation
By Kevin Xu on 01/04/2018
Species: Mouse

Good reproducibility


product review
By Harika Vemula on 01/04/2018
Species: Rat

in in-vivo studies


NMDA antagonist
By Anonymous on 07/17/2017
Species: Mouse

NMDA antagonist


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