Chemical Name: L-(+)-2-Amino-5-phosphonopentanoic acid
Biological ActivityL-AP5 is an NMDA antagonist and an agonist at quisqualate-sensitized AP6 site, where it is more potent than the isomer D-AP5. L-AP5 is more potent than D-AP5 at depressing synaptic responses at amino acid-induced and synaptic excitation of cat spinal neurons.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
Davies and Watkins
Brain Res., 1982;235:378
Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Schulte et al.
Brain Res., 1994;649:203
Citations for L-AP5
The citations listed below are publications that use Tocris products. Selected citations for L-AP5 include:
3 Citations: Showing 1 - 3
Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice.
Authors: Fan Et al.
Front Cell Neurosci 2016;10:74
GAT-3 transporters regulate inhibition in the neocortex.
J Neurophysiol 2005;94:4533
Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-MthD.-aspartate receptor signaling.
Authors: Fernández-Monreal Et al.
J Biol Chem 2004;279:50850
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