Catalog Number: 0107
Chemical Name: L-(+)-2-Amino-5-phosphonopentanoic acid
Biological Activity
NMDA antagonist. Also agonist at quisqualate-sensitized AP6 site, where it is more potent than the isomer D-AP5.

DL Mixture and D-isomer also available.

Technical Data
  • M.Wt:
    197.13
  • Formula:
    C5H12NO5P
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    79055-67-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
    Davies and Watkins
    Brain Res., 1982;235:378
  2. The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
    Evans et al.
    Br.J.Pharmacol., 1982;75:65
  3. Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
    Schulte et al.
    Brain Res., 1994;649:203
Citations:

The citations listed below are publications that use Tocris products. Selected citations for L-AP5 include:

2 Citations: Showing 1 - 2
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  1. GAT-3 transporters regulate inhibition in the neocortex.
    Authors: Kinney
    J Neurophysiol 2005;94:4533
  2. Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling.
    Authors: Fernández-Monreal Et al.
    J Biol Chem 2004;279:50850
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