Chemical Name: L-(+)-2-Amino-5-phosphonopentanoic acid
Biological ActivityL-AP5 is an NMDA antagonist and an agonist at quisqualate-sensitized AP6 site, where it is more potent than the isomer D-AP5. L-AP5 is more potent than D-AP5 at depressing synaptic responses at amino acid-induced and synaptic excitation of cat spinal neurons.
D-isomer, DL mixture and sodium salt also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
Davies and Watkins
Brain Res., 1982;235:378
Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Schulte et al.
Brain Res., 1994;649:203
Citations for L-AP5
The citations listed below are publications that use Tocris products. Selected citations for L-AP5 include:
3 Citations: Showing 1 - 3
Reduced Hyperpolarization-Activated Current Contributes to Enhanced Intrinsic Excitability in Cultured Hippocampal Neurons from PrP(-/-) Mice.
Authors: Fan Et al.
Front Cell Neurosci 2016;10:74
GAT-3 transporters regulate inhibition in the neocortex.
J Neurophysiol 2005;94:4533
Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-MthD.-aspartate receptor signaling.
Authors: Fernández-Monreal Et al.
J Biol Chem 2004;279:50850
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