DL-AP5

  ( 75 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0105
Alternate Names:DL-APV
Chemical Name:DL-2-Amino-5-phosphonopentanoic acid
Product Details
Citations (75)
Supplemental Products
Reviews
Biological Activity
Potent NMDA antagonist.

D-isomer, L-isomer and Sodium Salt also available.

Technical Data
  • M.Wt:
    197.13
  • Formula:
    C5H12NO5P
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in 1eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    76326-31-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for DL-AP5 include:

75 Citations: Showing 1 - 10
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  1. Astrocytes modulate thalamic sensory processing via mGlu2 receptor activation.
    Authors: Copeland Et al.
    Neuropharmacology  2017;121:100
  2. Electrophysiological Assessment of Serotonin and GABA Neuron Function in the Dorsal Raphe during the Third Trimester Equivalent Developmental Period in Mice(1,2,3).
    Authors: Morton Et al.
    Eneuro  2016;2
  3. Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.
    Authors: Araki Et al.
    Neuron  2015;85:173
  4. Development of a neuroprotective peptide that preserves survival pathways by preventing Kidins220/ARMS calpain processing induced by excitotoxicity.
    Authors: Gamir-Morralla Et al.
    Cell Death Dis  2015;6:e1939
  5. IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala.
    Authors: Bajo Et al.
    Front Pharmacol  2015;6:49
  6. GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome.
    Authors: Ferreira Et al.
    J Neurosci  2015;35:8462
  7. PAR1-activated astrocytes in the nucleus of the solitary tract stimulate adjacent neurons via NMDA receptors.
    Authors: Vance Et al.
    J Neurosci  2015;35:776
  8. Cortical Synaptic Inhibition Declines during Auditory Learning.
    Authors: Sarro Et al.
    J Neurosci  2015;35:6318
  9. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    J Neurosci  2015;35:5680
  10. IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells.
    Authors: Mellough Et al.
    Stem Cells  2015;33:2416
  11. In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model.
    Authors: Hipólito Et al.
    Pain  2015;156:849
  12. Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.
    Authors: Kirwan Et al.
    Development  2015;142:3178
  13. Rosiglitazone Suppresses In Vitro Seizures in Hippocampal Slice by Inhibiting Presynaptic Glutamate Release in a Model of Temporal Lobe Epilepsy.
    Authors: Wong Et al.
    PLoS One  2015;10:e0144806
  14. Both neurons and astrocytes exhibited tetrodotoxin-resistant metabotropic glutamate receptor-dependent spontaneous slow Ca2+ oscillations in striatum.
    Authors: Tamura Et al.
    PLoS One  2014;9:e85351
  15. The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.
    Authors: Purohit Et al.
    PLoS One  2014;9:e103976
  16. Dynamic properties of the alkaline vesicle population at hippocampal synapses.
    Authors: Röther Et al.
    PLoS One  2014;9:e102723
  17. LTD expression is independent of glutamate receptor subtype.
    Authors: Granger and Nicoll
    Front Synaptic Neurosci  2014;6:15
  18. Synapse elimination and learning rules co-regulated by MHC class I H2-Db.
    Authors: Lee Et al.
    Nature  2014;509:195
  19. Repeated binge-like ethanol drinking alters ethanol drinking patterns and depresses striatal GABAergic transmission.
    Authors: Wilcox Et al.
    Neuropsychopharmacology  2014;39:579
  20. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats.
    Authors: Kallupi Et al.
    Neuropsychopharmacology  2014;39:1081
  21. Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations.
    Authors: Rovó Et al.
    J Neurosci  2014;34:7137
  22. A novel mechanism for nicotinic potentiation of glutamatergic synapses.
    Authors: Halff Et al.
    J Neurosci  2014;34:2051
  23. Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by Dopamine in the Basolateral Amygdala.
    Authors: Diaz Et al.
    Front Pediatr  2014;2:46
  24. GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
    Authors: Berlinguer-Palmini Et al.
    PLoS One  2013;8:e82180
  25. Low voltage activation of KCa1.1 current by Cav3-KCa1.1 complexes.
    Authors: Rehak Et al.
    PLoS One  2013;8:e61844
  26. Autism-related deficits via dysregulated eIF4E-dependent translational control.
    Authors: Gkogkas Et al.
    Nature  2013;493:371
  27. Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
    Authors: Tyagarajan Et al.
    J Biol Chem  2013;288:9634
  28. Increased neuronal activity fragments the Golgi complex.
    Authors: Thayer Et al.
    Proc Natl Acad Sci U S A  2013;110:1482
  29. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.
    Authors: Klug Et al.
    PLoS One  2012;7:e45323
  30. Local hypocretin-1 modulates terminal dopamine concentration in the nucleus accumbens shell.
    Authors: Patyal Et al.
    Front Behav Neurosci  2012;6:82
  31. Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons.
    Authors: Mulholland Et al.
    Alcohol  2012;46:569
  32. Disruption of Eaat2b, a glutamate transporter, results in abnormal motor behaviors in developing zebrafish.
    Authors: McKeown Et al.
    Dev Biol  2012;362:162
  33. Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.
    Authors: Vivar Et al.
    Eur J Neurosci  2012;35:76
  34. Activity-dependent regulation of inhibition via GAD67.
    Authors: Lau and Murthy
    J Neurosci  2012;32:8521
  35. LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice.
    Authors: Seese Et al.
    J Neurosci  2012;32:7403
  36. Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
    Authors: Peterfi Et al.
    J Neurosci  2012;32:14448
  37. Spinal cord NMDA receptor-mediated activation of mammalian target of rapamycin is required for the development and maintenance of bone cancer-induced pain hypersensitivities in rats.
    Authors: Shih Et al.
    J Pain  2012;13:338
  38. Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
    Authors: Chacón Et al.
    Development  2012;139:3200
  39. Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool.
    Authors: Lee Et al.
    Proc Natl Acad Sci U S A  2012;109:E765
  40. Specificity and actions of an arylaspartate inhibitor of glutamate transport at the Schaffer collateral-CA1 pyramidal cell synapse.
    Authors: Sun Et al.
    PLoS One  2011;6:e23765
  41. GABAergic signalling in a neurogenic niche of the turtle spinal cord.
    Authors: Reali Et al.
    J Physiol  2011;589:5633
  42. Neurogranin phosphorylation fine-tunes long-term potentiation.
    Authors: Zhong Et al.
    Eur J Neurosci  2011;33:244
  43. Functional NMDA receptors at axonal growth cones of young hippocampal neurons.
    Authors: Wang Et al.
    J Neurosci  2011;31:9289
  44. Homeostatic synaptic plasticity through changes in presynaptic calcium influx.
    Authors: Zhao Et al.
    J Neurosci  2011;31:7492
  45. Neto1 is an auxiliary subunit of native synaptic kainate receptors.
    Authors: Tang Et al.
    J Neurosci  2011;31:10009
  46. SynGAP moves out of the core of the postsynaptic density upon depolarization.
    Authors: Yang Et al.
    Neuroscience  2011;192:132
  47. M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes.
    Authors: Rio Et al.
    J Neurosci  2010;30:6011
  48. SAP102 is a highly mobile MAGUK in spines.
    Authors: Zheng Et al.
    J Neurosci  2010;30:4757
  49. Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance.
    Authors: Torborg Et al.
    J Neurosci  2010;30:15628
  50. Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction.
    Authors: Han Et al.
    Am J Physiol Regul Integr Comp Physiol  2010;299:R129
  51. Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map.
    Authors: Noh Et al.
    Nat Neurosci  2010;13:232
  52. Regulation of stargazin synaptic trafficking by C-terminal PDZ ligand phosphorylation in bidirectional synaptic plasticity.
    Authors: Stein and Chetkovich
    J Neurochem  2010;113:42
  53. A mouse model of the human Fragile X syndrome I304N mutation.
    Authors: Zang Et al.
    PLoS Genet  2009;5:e1000758
  54. Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus.
    Authors: Sipilä Et al.
    J Neurosci  2009;29:6982
  55. Co-transmission of dopamine and GABA in periglomerular cells.
    Authors: Maher and Westbrook
    J Neurophysiol  2008;99:1559
  56. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci  2008;28:8040
  57. NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia.
    Authors: Manning Et al.
    J Neurosci  2008;28:6670
  58. Competition between calcium-activated K+ channels determines cholinergic action on firing properties of basolateral amygdala projection neurons.
    Authors: Power and Sah
    J Neurosci  2008;28:3209
  59. White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity.
    Authors: Baltan Et al.
    J Neurosci  2008;28:1479
  60. Sequential changes in AMPA receptor targeting in the developing neocortical excitatory circuit.
    Authors: Brill and Huguenard
    J Neurosci  2008;28:13918
  61. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
    Authors: Kash Et al.
    J Neurosci  2008;28:13856
  62. Neuregulin-1 enhances depolarization-induced GABA release.
    Authors: Woo Et al.
    Neuron  2007;54:599
  63. Long-term modifications in the strength of excitatory associative inputs in the piriform cortex.
    Authors: Young and Sun
    Chem Senses  2007;32:783
  64. Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.
    Authors: Nosyreva and Huber
    J Neurophysiol  2006;95:3291
  65. Regulation of thalamocortical patterning and synaptic maturation by NeuroD2.
    Authors: Ince-Dunn Et al.
    Neuron  2006;49:683
  66. Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function.
    Authors: Kopp Et al.
    J Neurosci  2006;26:12456
  67. GAT-3 transporters regulate inhibition in the neocortex.
    Authors: Kinney
    J Neurophysiol  2005;94:4533
  68. Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
    Authors: Lenz and Avruch
    J Biol Chem  2005;280:38121
  69. Programmed and induced phenotype of the hippocampal granule cells.
    Authors: Gómez-Lira Et al.
    J Neurosci  2005;25:6939
  70. Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function.
    Authors: Bender Et al.
    Eur J Neurosci  2005;22:2669
  71. Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors.
    Authors: Melyan Et al.
    J Neurosci  2004;24:4530
  72. Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport.
    Authors: Ronesi Et al.
    J Neurosci  2004;24:1673
  73. A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1.
    Authors: Selcher Et al.
    Learn Mem  2003;10:26
  74. A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses.
    Authors: Yamaguchi Et al.
    Proc Natl Acad Sci U S A  2002;99:14536
  75. Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate.
    Authors: Bureau Et al.
    Proc Natl Acad Sci U S A  2000;97:6838
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Tocris Small Molecules
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D-AP5

0106 327  
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DL-AP5 Sodium salt

3693 4  
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L-AP5

0107 3  
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VersaClone cDNA Plasmids
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Human GRIN1/NMDAR1 (NP_015566) VersaClone cDNA

RDC1219
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Human GRIN2B/NMDAR2B (NP_000825) VersaClone cDNA

RDC1221
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Human GRIN2A/NMDAR2A (NP_000824) VersaClone cDNA

RDC1220
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Average Rating: 5 (Based on 1 review)

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  Rat Erik Dustrude 01/04/2018
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Species Rat

Other Experimental Details

Other Experimental Details 5 minutes perfusion at ~1.5ml/min was sufficient for the full effect.

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