Potent inhibitor of p56lck
tyrosine kinase activity (IC50
= 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn
tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Mobilizes intracellular Ca2+
in dermal fibroblasts and inhibits Ras function. Also inhibits LIMK1/2, as well as migration and invasion of breast cancer cells in vitro
Soluble to 25 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia.
Hiramatsu et al.
Cancer Lett., 1993;73:161
Damnacanthal is a highly potent, selective inhibitor fo p56lck tyrosine kinase activity.
Faltynek et al.
Mechanism of damnacanthal-induced [Ca2+]i elevation in human dermal fibroblasts.
Aoki et al.