Chemical Name: 9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde
Biological ActivityDamnacanthal is a potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Mobilizes intracellular Ca2+ in dermal fibroblasts and inhibits Ras function. Also inhibits LIMK1/2, as well as migration and invasion of breast cancer cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia.
Hiramatsu et al.
Cancer Lett., 1993;73:161
Damnacanthal is a highly potent, selective inhibitor fo p56lck tyrosine kinase activity.
Faltynek et al.
Mechanism of damnacanthal-induced [Ca2+]i elevation in human dermal fibroblasts.
Aoki et al.
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