Damnacanthal

Catalog # Availability Size / Price Qty
1936/1
Damnacanthal | CAS No. 477-84-9 | Src Family Kinase Inhibitors
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Description: Potent, selective p56lck inhibitor; also LIMK1/2 inhibitor

Chemical Name: 9,10-Dihydroxy-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde

Purity: ≥98%

Product Details
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Biological Activity

Potent inhibitor of p56lck tyrosine kinase activity (IC50 = 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn and p60src tyrosine kinases, > 40-fold selectivity over c-ErbB2, EGF- and insulin-receptor tyrosine kinases, and > 100-fold selectivity over PKA and PKC. Mobilizes intracellular Ca2+ in dermal fibroblasts and inhibits Ras function. Also inhibits LIMK1/2, as well as migration and invasion of breast cancer cells in vitro.

Technical Data

M.Wt:
282.25
Formula:
C16H10O5
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
477-84-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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