Daxx Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-77011

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Rat (100%). Backed by our 100% Guarantee.

Applications

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Daxx Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human Daxx. The immunogen is located within the last 50 amino acids of Daxx. Amino Acid Squence: TSVATQCDPEEIIVLSDSD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

120 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Daxx Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: Daxx Antibody - BSA Free [NBP1-77011]

Immunocytochemistry/ Immunofluorescence: Daxx Antibody - BSA Free [NBP1-77011]

Immunocytochemistry/Immunofluorescence: Daxx Antibody [NBP1-77011] - HeLa cells with DAXX antibody at 10 ug/ml.
Daxx Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: Daxx Antibody - BSA Free [NBP1-77011] -

Immunocytochemistry/ Immunofluorescence: Daxx Antibody - BSA Free [NBP1-77011] - Immunofluorescence of Daxx in Hela cells with Daxx antibody at 20 ug/mL.

Green: Daxx Antibody
Blue: DAPI staining

Applications for Daxx Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Western Blot

1 ug/ml
Application Notes
A 120 kDa major band can be detected in Western Blot.

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Daxx

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.

Long Name

Fas Death Domain-associated Protein

Alternate Names

BING2, DAP6

Gene Symbol

DAXX

UniProt

CAG33366 (Human)

Additional Daxx Products

Product Documents for Daxx Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Daxx Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Apoptosis Adaptor Proteins

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Protocols

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FAQs

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