DC-SIGN/CD209 Antibody (111H2.02) - Azide and BSA Free

Name: DC-SIGN/CD209 Antibody (111H2.02) - Azide and BSA Free
Brand: Novus Biologicals
SKU: DDX0209
Price: 619 USD
Availability: InStock

Novus Biologicals | Catalog # DDX0209

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Product Specifications
Scientific Data
Applications
Flow Cytometry
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG_2B Clone # 111H2.02

Format

Azide and BSA Free

View all DC-SIGN/CD209 Primary Antibodies »

Product Specifications

Immunogen

HeLa cells stably transfected-with human DC-SIGN

Reactivity Notes

Human

Marker

Dendritic Cell Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2B

Scientific Data Images for DC-SIGN/CD209 Antibody (111H2.02) - Azide and BSA Free

Immunohistochemistry: DC-SIGN/CD209 Antibody (111H2.02) [DDX0209]

Immunohistochemistry: DC-SIGN/CD209 Antibody (111H2.02) [DDX0209] - Staining of formalin fixed and paraffin-embedded human skin sections with 111H2.02.

Flow Cytometry: DC-SIGN/CD209 Antibody (111H2.02) [DDX0209]

Flow Cytometry: DC-SIGN/CD209 Antibody (111H2.02) [DDX0209] - Analysis using the Alexa Fluor (R) 488 conjugate of DDX0209.

Flow Cytometry: DC-SIGN/CD209 Antibody (111H2.02) [DDX0209]

Flow Cytometry: DC-SIGN/CD209 Antibody (111H2.02) [DDX0209] - Analysis using the Alexa Fluor (R) 488 conjugate of DDX0209. A) Staining of NIH3T3 transfected cells with 111H2.02. B) Endogenous expression revealed by Flow staining with 111H2.02.

Applications for DC-SIGN/CD209 Antibody (111H2.02) - Azide and BSA Free

Application

Recommended Usage

Immunohistochemistry

1:10-1:500

Application Notes

Immunohistochemistry

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Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

Tris-NaCl (pH 8.0)

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DC-SIGN/CD209

DC-SIGN encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Long Name

Dendritic Cell-specific ICAM-3-grabbing Non-integrin 1

Alternate Names

CD209, CLEC4L, DC-SIGN1, DCSIGN

Gene Symbol

CD209

UniProt

NP_066978

Additional DC-SIGN/CD209 Products

Product Documents for DC-SIGN/CD209 Antibody (111H2.02) - Azide and BSA Free

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Certificate of Analysis

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Product Specific Notices for DC-SIGN/CD209 Antibody (111H2.02) - Azide and BSA Free

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.