Decynium 22

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4722/50
Decynium 22 | CAS No. 977-96-8 | Nucleoside Transporter Inhibitors
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Description: PMAT inhibitor

Chemical Name: 1-Ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]quinolinium iodide

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM).

Technical Data

M.Wt:
454.35
Formula:
C23H23IN2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
977-96-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Decynium 22

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Also a non-competitive alpha-1 adrenoceptor antagonist
By Alex Voisey on 10/25/2020
Application: Species: Rat

Excellent for blocking organic cation transport at 1 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.


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