Chemical Name: 1-Ethyl-2-[(1-ethyl-2(1H)-quinolinylidene)methyl]quinolinium iodide
Biological ActivityInhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM).
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Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Engel and Wang
Podocyte-specific expression of organic cation transporter PMAT: implication in puromycin aminonucleoside nephrotoxicity.
Xia et al.
Am.J.Physiol.Renal Physiol., 2009;296:F1307
Citation for Decynium 22
The citations listed below are publications that use Tocris products. Selected citations for Decynium 22 include:
1 Citation: Showing 1 - 1
Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-α production to induce dopaminergic neuron damage.
Authors: He Et al.
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Excellent for blocking organic cation transport at 1 uM in rat aorta. However also acts as non-competitive antagonist of alpha-1 adrenoceptors. This is evidenced by the fact it can block vasoconstrictor responses induced by the alpha-1 adrenoceptor agonist phenylephrine in a non-competitive manner.