Catalog Number: 4591
Biological Activity
Potent δ-opioid receptor agonist (IC50 = 0.5 nM in human granulocytes). Exhibits a high rate of blood-brain barrier penetrance.
Technical Data
  • M.Wt:
    768.87
  • Formula:
    C37H52N8O10
  • Sequence:
    YAFDVVG

    (Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in 20% formic acid
  • Storage:
    Store at -20°C
  • CAS No:
    122752-15-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for δ opioid binding sites.
    Erspamer et al.
    Proc.Natl.Acad.Sci.USA, 1989;86:5188
  2. Deltorphin transport across the blood-brain barrier.
    Fiori et al.
    Proc.Natl.Acad.Sci.USA, 1997;94:9469
  3. [D-Ala2]Deltorphin I binding and pharmacological evidence for a special subtype of δ opioid receptor on human and invertebrate immune cells.
    Stefano et al.
    Proc.Natl.Acad.Sci.USA, 1992;89:9316
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Deltorphin I include:

1 Citations: Showing 1 - 1

  1. Spinal activation of delta opioid receptors alleviates cancer-related bone pain.
    Authors: Otis Et al.
    Neuroscience 2011;183:221

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